|
Hypoglycemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
5) the sensitivity for the composite adverse perinatal outcome varied substantially among standards (15% for NICHD to 32% for FMF) given mostly to differences in the FPR, and they subsided when the FPR was set to the same value (10%); 6) the comparison of the AUC revealed a significant improvement for the PRB/NICHD (AUC=0.70) compared to Hadlock (AUC=0.66) and FMF (AUC=0.64) standards for the prediction of perinatal mortality; complementarily, the evaluation of the partial AUC (FPR<10%) revealed that the INTERGROWTH-21 standard had an advantage over the Hadlock standard for NICU admissions and mechanical ventilation (all, p<0.05).
|
31006913 |
2020 |
|
Severe intellectual disability
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A female patient with retinoblastoma and severe intellectual disability carrying an X;13 balanced translocation without rearrangement in the RB1 gene: a case report.
|
31806026 |
2019 |
|
Fibrofolliculoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
To clarify their possible relationship to SCL, 25 cases of trichodiscoma and fibrofolliculoma with stromal "lipomatous metaplasia" were collected and examined using immunohistochemical stains [CD34 and retinoblastoma-1 (RB1) protein] and fluorescence in situ hybridization (RB1 deletion).
|
30908293 |
2019 |
|
Precursor B-lymphoblastic lymphoma/leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Herein, we present cytogenetic and molecular analysis of a case of B-ALL in a 16-year-old Caucasian boy with t(3;9) FOXP1-ABL1 rearrangement and concurrent loss of IKZF1, CDKN2A, and RB1 gene loci, meeting WHO criteria for Ph-like ALL.
|
30938769 |
2019 |
|
Trichodiscoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
To clarify their possible relationship to SCL, 25 cases of trichodiscoma and fibrofolliculoma with stromal "lipomatous metaplasia" were collected and examined using immunohistochemical stains [CD34 and retinoblastoma-1 (RB1) protein] and fluorescence in situ hybridization (RB1 deletion).
|
30908293 |
2019 |
|
Secondary Neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
Interestingly, ectopic expression of miR-200b in the Caki-1 and OSRC-2 cell lines suppresses cell migration and invasion in vitro as well as tumor metastases in vivo.
|
31130475 |
2019 |
|
Ph-Like Acute Lymphoblastic Leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Herein, we present cytogenetic and molecular analysis of a case of B-ALL in a 16-year-old Caucasian boy with t(3;9) FOXP1-ABL1 rearrangement and concurrent loss of IKZF1, CDKN2A, and RB1 gene loci, meeting WHO criteria for Ph-like ALL.
|
30938769 |
2019 |
|
Renal Cell Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we found that AIM2 expression was significantly decreased in RCC patient specimens and renal carcinoma cell lines (786-O and OSRC-2).
|
30160343 |
2018 |
|
Cervix Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
The present analysis investigated the prevalence of the nucleotide polymorphism A153104G, which is located at intron 18 of the RB1 gene, and investigated the impact of the polymorphic variability in the exon 19 and its flanking intronic sequences on the severity of cervical disease in HPV16-positive Greek women.
|
30303478 |
2018 |
|
Cervical dysplasia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Moreover, sequence analysis of the amplicons revealed that the polymorphic variability in the RB1 gene increased with the severity of the cervical dysplasia.
|
30303478 |
2018 |
|
Gastroenteritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The results showed that miR-4331 elevated mitochondrial Ca<sup>2+</sup> level, reduced MMP, targets Retinoblastoma 1 (RB1), upregulated IL1RAP, and induced activation of p38 MAPK pathway during TGEV infection.
|
29217619 |
2018 |
|
Cervical Intraepithelial Neoplasia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Moreover, sequence analysis of the amplicons revealed that the polymorphic variability in the RB1 gene increased with the severity of the cervical dysplasia.
|
30303478 |
2018 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here, we found that AIM2 expression was significantly decreased in RCC patient specimens and renal carcinoma cell lines (786-O and OSRC-2).
|
30160343 |
2018 |
|
High-Grade Squamous Intraepithelial Lesions
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
The link between the observed polymorphic variability and the progress of cervical disease was reflected in the molecular evolutionary analysis that was performed on the exon 19 of the RB1 gene, since negative selective pressure was acting upon exon 19 in the control and low-grade squamous intraepithelial lesion (LSIL) cervical samples, while positive selective pressure was acting upon exon 19 in the high-grade squamous intraepithelial lesion (HSIL) specimens.
|
30303478 |
2018 |
|
precancerous lesions
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
The A153104G nucleotide polymorphism did not emerge as a potential biomarker for the development of precancerous lesions in the Greek patients, while the accumulation of sequence variations in RB1 gene might influence patients' susceptibility towards the progression of cervical neoplasia.
|
30303478 |
2018 |
|
Large cell neuroendocrine carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The same outcome for chemotherapy treatment was observed in LCNEC tumors harboring an <i>RB1</i> mutation or lost RB1 protein.<b>Conclusions:</b> Patients with LCNEC tumors that carry a wild-type <i>RB1</i> gene or express the RB1 protein do better with NSCLC-GEM/TAX treatment than with SCLC-PE chemotherapy.
|
29066508 |
2018 |
|
Low Grade Squamous Intraepithelial Neoplasia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The link between the observed polymorphic variability and the progress of cervical disease was reflected in the molecular evolutionary analysis that was performed on the exon 19 of the RB1 gene, since negative selective pressure was acting upon exon 19 in the control and low-grade squamous intraepithelial lesion (LSIL) cervical samples, while positive selective pressure was acting upon exon 19 in the high-grade squamous intraepithelial lesion (HSIL) specimens.
|
30303478 |
2018 |
|
Liver regeneration disorder
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
MAPK signaling pathway, NF‑kappa B signaling pathway, and Toll‑like receptor signaling pathway were involved in LDABS‑mediated liver regeneration, with Retinoblastoma 1 (Rb1), Cyclin D1, Cyclin‑dependent kinase 4, Mitogen‑activated protein kinase 10 (Mapk10) and CAMP responsive element binding protein 1 genes in the initiation phase, Kirsten rat sarcoma viral oncogene homolog (Kras), tumor protein 53, MYC proto‑oncogene, BHLH transcription factor, Cyclin E1 and Heat shock protein family B (small) member 1 genes in the proliferation phase, Kras, Rb1, Jun proto‑oncogene, AP‑1 transcription factor subunit, Cyclin D2 and Mapk10 genes in the termination phase were identified as key genes in LDABS‑mediated liver regeneration using MAPK signaling PCR array analysis.
|
29115531 |
2018 |
|
Teratoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Teratoma analysis further revealed a role for the transcription factor ZEB1 in RB1-mediated ectoderm differentiation.
|
28392220 |
2017 |
|
Chronic endometritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Increased expressions of ERα, ERβ, PRA, and PRB were observed in the stromal cells of CE patients in comparison to non-CE patients, whereas increased expressions of ERα and ERβ were detected in the glandular cells of CE.
|
28259137 |
2017 |
|
Malignant Glioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
To investigate the roles of miR-215 in high-grade glioma and to clarify the regulation of retinoblastoma 1 (RB1) by miR-215.
|
28573541 |
2017 |
|
Parathyroid Gland Adenocarcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Other genes involved in sporadic PC include germline MEN1 and rearranged during transfection (RET) mutations and somatic alterations of the retinoblastoma 1 (RB1) and tumor protein P53 (TP53) genes, as well as epigenetic modifications including DNA methylation and histone modifications, and microRNA misregulation.
|
28881068 |
2017 |
|
Adult Teratoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Teratoma analysis further revealed a role for the transcription factor ZEB1 in RB1-mediated ectoderm differentiation.
|
28392220 |
2017 |
|
Childhood Teratoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Teratoma analysis further revealed a role for the transcription factor ZEB1 in RB1-mediated ectoderm differentiation.
|
28392220 |
2017 |
|
High grade glioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
To investigate the roles of miR-215 in high-grade glioma and to clarify the regulation of retinoblastoma 1 (RB1) by miR-215.
|
28573541 |
2017 |