Liver carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Advanced-stage HCC (BCLC B/C) showed higher frequencies of splicing factor 3b subunit 1 (SF3B1) (P = 0.0003), TP53 (P = 0.0006), and RB Transcriptional Corepressor 1 mutations (P = 0.03).
|
31206197 |
2020 |
Liver carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Altogether, 40% of the HCC specimens (16/40) showed hyper- or hypomethylation at the CpG island in intron 2 of the RB1 gene.
|
24838394 |
2014 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Cell cycle control involving RB1 gene-related cell inhibitors is one of the main regulatory pathways were reported to be altered in hepatocellular carcinoma (HCC).
|
24254306 |
2014 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Two of the 26 HCC and one of the 9 HB showed >10% tumour nuclear staining for pRb protein.
|
24935581 |
2014 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Key mechanisms underlying the effect of PPARγ in HCC include upregulation of cell adhesion genes, E-cadherin and SYK (spleen tyrosine kinase), extracellular matrix regulator tissue inhibitors of metalloproteinase (TIMP) 3, tumour suppressor gene retinoblastoma 1, and downregulation of pro-metastatic genes MMP9 (matrix metallopeptidase 9), MMP13, HPSE (heparanase), and Hepatocyte growth factor (HGF).
|
22472882 |
2012 |
Liver carcinoma
|
0.400 |
PosttranslationalModification
|
disease |
LHGDN |
Effect of promoter methylation of the p16 gene on phosphorylation of retinoblastoma gene product and growth of hepatocellular carcinoma cells.
|
16254459 |
2005 |
Liver carcinoma
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
All 24 HCCs with RB1 promoter methylation lacked RB1 expression, while none of the 67 cases with RB1 expression exhibited RB1 methylation (p < 0.0001), suggesting that promoter methylation is a major mechanism of loss of RB1 expression in HCCs.
|
12845670 |
2003 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We investigated p14(ARF), p15(INK4B), p16(INK4A), p18(INK4C), and RB1 genes in a series of HCCs and associated cirrhosis with the goal of ascertaining their pattern of inactivation by gene methylation.
|
12143052 |
2002 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Cell cycle deregulation in liver lesions of rats with and without genetic predisposition to hepatocarcinogenesis.
|
12029619 |
2002 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Retinoblastoma gene mutations in chemically induced liver tumor samples of Japanese medaka (Oryzias latipes).
|
14961299 |
2001 |
Liver carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These findings are applicable to HCC with abberrations of both p53 and pRb genes, and may not represent the universal effects of p53 in hepatic cells.
|
10952243 |
2000 |
Liver carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Allelic alteration of the Rb-1 gene was observed in two cases, deletion of both alleles in the hepatocellular carcinoma component of case 3 (combined type) and replication error of the same pattern in both components of case 4 (mixed type).
|
8957064 |
1996 |
Liver carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Deletions of chromosome 13q, mutations in Retinoblastoma 1, and retinoblastoma protein state in human hepatocellular carcinoma.
|
8033150 |
1994 |