Breast Carcinoma
|
0.600 |
GenomicAlterations
|
disease |
CGI |
|
|
|
Breast Carcinoma
|
0.600 |
CausalMutation
|
disease |
CGI |
|
|
|
Breast Carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We have analysed the organisation of the retinoblastoma (RB1) gene in 77 primary breast carcinomas, in metastatic tissue derived from 16 of those primary tumours, and in a variety of benign breast lesions.
|
2543943 |
1989 |
Breast Carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Classical examples are the Rb-1 gene associated with the development of retinoblastoma and the p53 gene, which is associated with a wider range of neoplasms, including breast cancer.
|
1336726 |
1992 |
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
In order to evaluate the role of RB1 in cancer, the wild type RB1 gene was introduced into the RB1-deleted breast cancer cell line MDA-468-S4 and retinoblastoma cell lines WERI-Rb1 and Y-79.
|
1732054 |
1992 |
Breast Carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Association between RB-1 gene alterations and factors of favourable prognosis in human breast cancer, without effect on survival.
|
7615356 |
1995 |
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Chromosome 13 contains at least two cancer genes, the well-characterized RB1 gene located at 13q14 and the breast cancer-susceptibility gene, BRCA2, recently localized to 13q12.
|
7547638 |
1995 |
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
This study shows a major role of the RB1 gene in the pathogenesis of breast cancer.
|
11108660 |
2000 |
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
These results suggest that both PRA and PRB are strongly associated with ERalpha in human breast and this relation may be disturbed in breast cancer.
|
11267940 |
2001 |
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
PR negative cell lines stably transfected to express only PRA (MCF-7Mll/PRA) or PRB (MDA-MB-231/PRB), and tissue sections of human breast carcinoma and normal endometrium were stained using an immunoperoxidase method.
|
11477119 |
2001 |
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
CTD_human |
E2F1 expression is related with the poor survival of lymph node-positive breast cancer patients treated with fluorouracil, doxorubicin and cyclophosphamide.
|
14672398 |
2003 |
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Using immunohistochemical techniques, we focused on the expression and phosphorylation of hormone receptors themselves and examined the phosphorylation of ER-alpha Ser118 and ER-alpha Ser167 and the expression of ER-alpha, ER-beta1, ER-betacx/beta2, progesterone receptor (PR), PRA, and PRB in the primary breast carcinomas of 75 patients with metastatic breast cancer who received first-line treatment with endocrine therapy after relapse.
|
16168121 |
2005 |
Breast Carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this study was to determine whether common variants in the RB1 gene are associated with breast cancer risk.
|
16685266 |
2006 |
Breast Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemical analysis showed no detectable expression of ERalpha, PRB and BRCA1 in 21/36 (58%), 20/36 (56%) and 23/36 (64%) tumors respectively; significant correlation was observed between promoter methylation and loss of protein expression confirming our hypothesis that promoter methylation is an important mechanism for transcriptional silencing of these genes in breast cancer in this population.
|
17599361 |
2007 |
Breast Carcinoma
|
0.600 |
PosttranslationalModification
|
disease |
BEFREE |
Progesterone receptor B (PRB) promoter hypermethylation in sporadic breast cancer: progesterone receptor B hypermethylation in breast cancer.
|
17896177 |
2008 |
Breast Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The loss of the retinoblastoma tumour suppressor encoded by the RB1 locus is a well-characterised occurrence in many tumour types; however, its role in breast cancer is less clear with many reports demonstrating a loss of heterozygosity that does not correlate with a loss of RB1 protein expression.
|
18782450 |
2008 |
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
CTD_human |
Caveolin-1-/- null mammary stromal fibroblasts share characteristics with human breast cancer-associated fibroblasts.
|
19234134 |
2009 |
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
CTD_human |
RB-pathway disruption in breast cancer: differential association with disease subtypes, disease-specific prognosis and therapeutic response.
|
20948315 |
2010 |
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
The tumor suppressor gene retinoblastoma 1 (RB1) is frequently lost in both luminal-B and triple-negative tumor (TNT; i.e., estrogen receptor-, progesterone receptor-, and human epidermal growth factor receptor 2-negative) breast cancer subtypes.
|
20679727 |
2010 |
Breast Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
However, alteration in PRA/PRB expression is often observed in aggressive breast cancer suggesting differential contribution of PR isoforms in carcinogenesis.
|
23029355 |
2012 |
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Progesterone receptor isoforms PRA and PRB differentially contribute to breast cancer cell migration through interaction with focal adhesion kinase complexes.
|
23485561 |
2013 |
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Additionally, using the RT(2) Profiler PCR Array, retinoblastoma 1 (RB1) was identified as a direct target of the BMP-6/miR-192 pathway in regulating cell proliferation in breast cancer.
|
24012720 |
2013 |
Breast Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
These data support a role for imbalanced PRA:PRB expression in breast cancer progression and relative benefit from endocrine treatment.
|
25917868 |
2015 |
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Consistently, in two human breast cancer xenograft models, one manipulated to overexpress PRA or PRB (IBH-6 cells), and the other expressing only PRA (T47D-YA) or PRB (T47D-YB), MFP selectively inhibited the growth of PRA-overexpressing tumors and stimulated IBH-6-PRB xenograft growth.
|
25363551 |
2015 |
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
We aimed at analyzing the respective contribution of PR isoforms, PRA and PRB, in breast cancer cell proliferation in a new estrogen-independent cell based-model, allowing independent PR isoforms analysis.
|
26474308 |
2015 |