Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Squamous cell carcinoma of esophagus
0.340 Biomarker disease BEFREE To understand the alterations of Rb tumor suppressor gene and the relationship between defects in the Rb and p53 pathways in human esophageal carcinogenesis, we examined the loss of heterozygosity (LOH) of the Rb gene and immunohistochemical staining of pRb protein in 56 esophageal squamous cell carcinoma specimens and related the results to the p53 gene alterations. 10353761 1999
Squamous cell carcinoma of esophagus
0.340 AlteredExpression disease BEFREE Protein expression of RB1 was examined in 31 ESC cell lines, and loss of expression was infrequent (6.5%), indicating that inactivation of the RB1 gene might not be responsible for lymph node metastasis. 10446988 1999
Squamous cell carcinoma of esophagus
0.340 Biomarker disease BEFREE Additional studies are warranted to define the role of the pRB protein as a biomarker for development of esophageal squamous cell carcinoma in individuals at high risk for this malignancy. 17461478 2007
Squamous cell carcinoma of esophagus
0.340 Biomarker disease BEFREE Therefore, the present study aimed to verify the RBN's ability to induce ESCC and assess the involvement of CDKN2A and Rb1 genes. 22938432 2012
Squamous cell carcinoma of esophagus
0.340 Biomarker disease CTD_human Genetic landscape of esophageal squamous cell carcinoma. 25151357 2014