Malignant neoplasm of breast
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
To directly investigate the effects of PR isoform expression on the breast cancer proteome, both in the presence and absence of progestin, PRA and PRB were independently stably expressed in T47DC42 PR-null breast cancer cells using a doxycycline (Dox)-regulated promoter.
|
31809870 |
2020 |
Malignant neoplasm of breast
|
0.600 |
Biomarker
|
disease |
BEFREE |
In conclusion, we show that HMW-FGF2 isoforms are PRB targets which confer endocrine resistance and are localized in the nuclei of breast cancer samples.
|
29956066 |
2018 |
Malignant neoplasm of breast
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Aberrant DNA methylation at the RB1 gene has been reported in sporadic retinoblastoma as well as other cancers including glioblastoma, hepatocellular carcinoma, and breast cancer.
|
29468542 |
2018 |
Malignant neoplasm of breast
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
These data support a role for imbalanced PRA:PRB expression in breast cancer progression and relative benefit from endocrine treatment.
|
25917868 |
2015 |
Malignant neoplasm of breast
|
0.600 |
Biomarker
|
disease |
BEFREE |
We aimed at analyzing the respective contribution of PR isoforms, PRA and PRB, in breast cancer cell proliferation in a new estrogen-independent cell based-model, allowing independent PR isoforms analysis.
|
26474308 |
2015 |
Malignant neoplasm of breast
|
0.600 |
Biomarker
|
disease |
BEFREE |
Consistently, in two human breast cancer xenograft models, one manipulated to overexpress PRA or PRB (IBH-6 cells), and the other expressing only PRA (T47D-YA) or PRB (T47D-YB), MFP selectively inhibited the growth of PRA-overexpressing tumors and stimulated IBH-6-PRB xenograft growth.
|
25363551 |
2015 |
Malignant neoplasm of breast
|
0.600 |
Biomarker
|
disease |
BEFREE |
Progesterone receptor isoforms PRA and PRB differentially contribute to breast cancer cell migration through interaction with focal adhesion kinase complexes.
|
23485561 |
2013 |
Malignant neoplasm of breast
|
0.600 |
Biomarker
|
disease |
BEFREE |
Additionally, using the RT(2) Profiler PCR Array, retinoblastoma 1 (RB1) was identified as a direct target of the BMP-6/miR-192 pathway in regulating cell proliferation in breast cancer.
|
24012720 |
2013 |
Malignant neoplasm of breast
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
However, alteration in PRA/PRB expression is often observed in aggressive breast cancer suggesting differential contribution of PR isoforms in carcinogenesis.
|
23029355 |
2012 |
Malignant neoplasm of breast
|
0.600 |
Biomarker
|
disease |
CTD_human |
RB-pathway disruption in breast cancer: differential association with disease subtypes, disease-specific prognosis and therapeutic response.
|
20948315 |
2010 |
Malignant neoplasm of breast
|
0.600 |
Biomarker
|
disease |
BEFREE |
The tumor suppressor gene retinoblastoma 1 (RB1) is frequently lost in both luminal-B and triple-negative tumor (TNT; i.e., estrogen receptor-, progesterone receptor-, and human epidermal growth factor receptor 2-negative) breast cancer subtypes.
|
20679727 |
2010 |
Malignant neoplasm of breast
|
0.600 |
Biomarker
|
disease |
CTD_human |
Caveolin-1-/- null mammary stromal fibroblasts share characteristics with human breast cancer-associated fibroblasts.
|
19234134 |
2009 |
Malignant neoplasm of breast
|
0.600 |
PosttranslationalModification
|
disease |
BEFREE |
Progesterone receptor B (PRB) promoter hypermethylation in sporadic breast cancer: progesterone receptor B hypermethylation in breast cancer.
|
17896177 |
2008 |
Malignant neoplasm of breast
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The loss of the retinoblastoma tumour suppressor encoded by the RB1 locus is a well-characterised occurrence in many tumour types; however, its role in breast cancer is less clear with many reports demonstrating a loss of heterozygosity that does not correlate with a loss of RB1 protein expression.
|
18782450 |
2008 |
Malignant neoplasm of breast
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemical analysis showed no detectable expression of ERalpha, PRB and BRCA1 in 21/36 (58%), 20/36 (56%) and 23/36 (64%) tumors respectively; significant correlation was observed between promoter methylation and loss of protein expression confirming our hypothesis that promoter methylation is an important mechanism for transcriptional silencing of these genes in breast cancer in this population.
|
17599361 |
2007 |
Malignant neoplasm of breast
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this study was to determine whether common variants in the RB1 gene are associated with breast cancer risk.
|
16685266 |
2006 |
Malignant neoplasm of breast
|
0.600 |
Biomarker
|
disease |
CTD_human |
E2F1 expression is related with the poor survival of lymph node-positive breast cancer patients treated with fluorouracil, doxorubicin and cyclophosphamide.
|
14672398 |
2003 |
Malignant neoplasm of breast
|
0.600 |
Biomarker
|
disease |
BEFREE |
These results suggest that both PRA and PRB are strongly associated with ERalpha in human breast and this relation may be disturbed in breast cancer.
|
11267940 |
2001 |
Malignant neoplasm of breast
|
0.600 |
Biomarker
|
disease |
BEFREE |
This study shows a major role of the RB1 gene in the pathogenesis of breast cancer.
|
11108660 |
2000 |
Malignant neoplasm of breast
|
0.600 |
Biomarker
|
disease |
BEFREE |
Deletion of regions on chromosome 13q containing the BRCA2 and RB1 genes has also been reported in sporadic breast cancers.
|
10193332 |
1998 |
Malignant neoplasm of breast
|
0.600 |
Biomarker
|
disease |
BEFREE |
Chromosome 13 contains at least two cancer genes, the well-characterized RB1 gene located at 13q14 and the breast cancer-susceptibility gene, BRCA2, recently localized to 13q12.
|
7547638 |
1995 |
Malignant neoplasm of breast
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Association between RB-1 gene alterations and factors of favourable prognosis in human breast cancer, without effect on survival.
|
7615356 |
1995 |
Malignant neoplasm of breast
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Classical examples are the Rb-1 gene associated with the development of retinoblastoma and the p53 gene, which is associated with a wider range of neoplasms, including breast cancer.
|
1336726 |
1992 |
Malignant neoplasm of breast
|
0.600 |
Biomarker
|
disease |
BEFREE |
In order to evaluate the role of RB1 in cancer, the wild type RB1 gene was introduced into the RB1-deleted breast cancer cell line MDA-468-S4 and retinoblastoma cell lines WERI-Rb1 and Y-79.
|
1732054 |
1992 |
Malignant neoplasm of breast
|
0.600 |
GenomicAlterations
|
disease |
CGI |
|
|
|