RB1, RB transcriptional corepressor 1, 5925

N. diseases: 339; N. variants: 239
Disease: melanoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025202
Disease: melanoma
melanoma 		0.090 PosttranslationalModification disease BEFREE Our studies establish SUV39H1 as an oncogene in melanoma and underscore the role of chromatin factors in regulating tumorigenesis.-Kim, G., Kim, J.-Y., Lim, S.-C., Lee, K. Y., Kim, O., Choi, H. S. SUV39H1/DNMT3A-dependent methylation of the RB1 promoter stimulates PIN1 expression and melanoma development. 29750576 2018
CUI: C0025202
Disease: melanoma
melanoma 		0.090 AlteredExpression disease LHGDN Survivin repression by p53, Rb and E2F2 in normal human melanocytes. 17916908 2008
CUI: C0025202
Disease: melanoma
melanoma 		0.090 GeneticVariation disease LHGDN Identification of ARHGEF17, DENND2D, FGFR3, and RB1 mutations in melanoma by inhibition of nonsense-mediated mRNA decay. 18677770 2008
CUI: C0025202
Disease: melanoma
melanoma 		0.090 GeneticVariation disease LHGDN The role of cell cycle regulatory proteins in the pathogenesis of melanoma. 16916716 2006
CUI: C0025202
Disease: melanoma
melanoma 		0.090 Biomarker disease LHGDN Recurrent patterns of dual RB and p53 pathway inactivation in melanoma. 16354195 2005
CUI: C0025202
Disease: melanoma
melanoma 		0.090 AlteredExpression disease LHGDN In vitro and in vivo tumor growth inhibition by a p16-mimicking peptide in p16INK4A-defective, pRb-positive human melanoma cells. 15389561 2005
CUI: C0025202
Disease: melanoma
melanoma 		0.090 Biomarker disease LHGDN Altered expression of cell cycle regulators Cyclin D1, p14, p16, CDK4 and Rb in nodular melanomas. 15547691 2004
CUI: C0025202
Disease: melanoma
melanoma 		0.090 PosttranslationalModification disease LHGDN Differentiation of human melanoma cells through p38 MAP kinase is associated with decreased retinoblastoma protein phosphorylation and cell cycle arrest. 12140374 2002
CUI: C0025202
Disease: melanoma
melanoma 		0.090 Biomarker disease BEFREE Finally, because of the recently documented inverse relationship between expression of p16 and pRb protein in a variety of tumor cell lines, we analysed some of the p16-positive and negative melanoma cell lines for the presence of pRb protein. 8649798 1996