RB1, RB transcriptional corepressor 1, 5925

N. diseases: 339; N. variants: 239
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1261473
Disease: Sarcoma
Sarcoma
0.350 Biomarker group BEFREE Retinoblastoma (RB1) gene involves in retinoblastoma, osteosarcoma, bladder, prostate, lung, breast carcinomas, and soft tissue sarcomas. 11919466 2002
CUI: C1261473
Disease: Sarcoma
Sarcoma
0.350 GeneticVariation group BEFREE No alterations in exon 21 of the RB1 gene in sarcomas and carcinomas of the breast, colon, and lung. 1381957 1992
CUI: C1261473
Disease: Sarcoma
Sarcoma
0.350 GeneticVariation group BEFREE Overall, 10 of 25 high-grade sarcomas had detectable alterations of the Rb-1 gene compared with only 1 of 11 low-grade tumors. 1988704 1991
CUI: C1261473
Disease: Sarcoma
Sarcoma
0.350 GeneticVariation group BEFREE Mutation of the p53 gene in human soft tissue sarcomas: association with abnormalities of the RB1 gene. 2216456 1990
CUI: C1261473
Disease: Sarcoma
Sarcoma
0.350 GeneticVariation group BEFREE Using a probe that detects a polymorphic locus within the RB1 gene we found loss of only one allele (heterozygous deletion) in 33% of soft tissue sarcomas examined, including two leiomyosarcomas, a malignant peripheral nerve sheath tumour, a rhabdomyosarcoma and a chondrosarcoma. 2765366 1989
CUI: C1261473
Disease: Sarcoma
Sarcoma
0.350 GenomicAlterations group CGI
CUI: C1261473
Disease: Sarcoma
Sarcoma
0.350 CausalMutation group CGI