|
Retinoblastoma
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
Retinoblastoma‑associated protein 48 (RbAp48), a highly abundant component of HDACs, is a critical mediator that controls the transforming activity of human papillomavirus 16 in cervical cancer cells.
|
28138695 |
2017 |
|
Retinoblastoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Retinoblastoma binding protein 4 (RbAp48) is a histone chaperone which has been suggested to play a role in gene silencing.
|
27222146 |
2016 |
|
Retinoblastoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
We previously isolated and identified retinoblastoma-associated proteins 46 (RbAp46) and 48 (RbAp48), which are associated with chromatin remodeling, histone deacetylation, and transcription repression, as proteins associated with the DNA-bound ERalpha.
|
18577416 |
2008 |
|
Retinoblastoma
|
0.050 |
Biomarker
|
disease |
LHGDN |
This RbAp48-mediated transformation of HPV16 is probably because of the regulation by RbAp48 of tumor suppressors retinoblastoma and p53, apoptosis-related enzymes caspase-3 and caspase-8, and oncogenic genes, including E6, E7, cyclin D1 (CCND1), and c-MYC.
|
17616526 |
2007 |
|
Retinoblastoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
PLK1, SOD1, E2F-3, two retinoblastoma binding proteins (RBQ1 and RBBP4) and HDGF were reduced after Bmi-1 inhibition.
|
17454639 |
2007 |
|
Retinoblastoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
This RbAp48-mediated transformation of HPV16 is probably because of the regulation by RbAp48 of tumor suppressors retinoblastoma and p53, apoptosis-related enzymes caspase-3 and caspase-8, and oncogenic genes, including E6, E7, cyclin D1 (CCND1), and c-MYC.
|
17616526 |
2007 |
|
Amnesia
|
0.040 |
Biomarker
|
disease |
BEFREE |
The epigenetic factor LIN-53 (RBBP4/7) associates with different chromatin-regulating complexes to safeguard cell identities in Caenorhabditis elegans as well as mammals, and has a role in preventing memory loss and premature aging in humans.
|
31397537 |
2019 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Furthermore, ALA-PDT down-regulates expression of HPV E6/E7 oncogene as well as up-regulate tumor suppressor RbAp48 protein.
|
28043143 |
2019 |
|
Memory Loss
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
The epigenetic factor LIN-53 (RBBP4/7) associates with different chromatin-regulating complexes to safeguard cell identities in Caenorhabditis elegans as well as mammals, and has a role in preventing memory loss and premature aging in humans.
|
31397537 |
2019 |
|
Amnesia
|
0.040 |
Biomarker
|
disease |
BEFREE |
Rbbp4 (involved in age-related memory loss) was increased in tibia callus after ovariectomy.
|
28860177 |
2018 |
|
Amnesia
|
0.040 |
Biomarker
|
disease |
BEFREE |
We have previously shown that the histone-binding protein RbAp48/Rbbp4 is a molecular determinant of Age-Related Memory Loss.
|
30355501 |
2018 |
|
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Mechanistically, ARMC12 physically interacts with retinoblastoma binding protein 4 (RBBP4) to facilitate the formation and activity of polycomb repressive complex 2, resulting in transcriptional repression of tumor suppressive genes.
|
30026490 |
2018 |
|
Memory Loss
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
We have previously shown that the histone-binding protein RbAp48/Rbbp4 is a molecular determinant of Age-Related Memory Loss.
|
30355501 |
2018 |
|
Memory Loss
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Rbbp4 (involved in age-related memory loss) was increased in tibia callus after ovariectomy.
|
28860177 |
2018 |
|
Amnesia
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Up-regulation of RbAp48 in the DG of aged wild-type mice ameliorated age-related hippocampus-based memory loss and age-related abnormalities in histone acetylation.
|
23986399 |
2013 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
The role of RbAp48 in radiosensitivity of cervical cancer cells was assessed by cell proliferation, counting, survival, and apoptosis as well as cell cycle and tumor growth assays with RbAp48 overexpression or gene silencing.
|
23756179 |
2013 |
|
Memory Loss
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
Up-regulation of RbAp48 in the DG of aged wild-type mice ameliorated age-related hippocampus-based memory loss and age-related abnormalities in histone acetylation.
|
23986399 |
2013 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
This RbAp48-mediated transformation of HPV16 is probably because of the regulation by RbAp48 of tumor suppressors retinoblastoma and p53, apoptosis-related enzymes caspase-3 and caspase-8, and oncogenic genes, including E6, E7, cyclin D1 (CCND1), and c-MYC.
|
17616526 |
2007 |
|
Carcinogenesis
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
Blocking the interaction between ARMC12 and RBBP4 by cell-penetrating inhibitory peptide activates the downstream gene expression and suppresses the tumorigenesis and aggressiveness of NB cells.
|
30026490 |
2018 |
|
Oestrogen deficiency
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Zileuton caused downregulation of Rbbp4 in the hippocampus and had an effect on bone healing, changed the expression of genes involved in cross talk between bones and brain, and may be a potent drug for further examination in estrogen deficiency-related dysfunction(s).
|
28860177 |
2018 |
|
Malignant tumor of cervix
|
0.030 |
Biomarker
|
disease |
BEFREE |
RbAp48 may be a therapeutic target that may help to improve the treatment of cervical cancer.
|
28138695 |
2017 |
|
Cervix carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
RbAp48 may be a therapeutic target that may help to improve the treatment of cervical cancer.
|
28138695 |
2017 |
|
cervical cancer
|
0.030 |
Biomarker
|
disease |
BEFREE |
RbAp48 may be a therapeutic target that may help to improve the treatment of cervical cancer.
|
28138695 |
2017 |
|
Carcinogenesis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Globally, RBBP4 positively and negatively regulates genes involved in critical cellular functions including tumorigenesis.
|
26972001 |
2016 |
|
Malignant tumor of cervix
|
0.030 |
Biomarker
|
disease |
BEFREE |
RbAp48 may be a potential target to improve the results of radiation therapy for patients with cervical cancer.
|
23756179 |
2013 |