|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
SAE2 plays an important role in tumor growth, metastasis, and chemotherapy sensitivity of H446 and is a potential clinical biomarker and therapeutic target in SCLC with high c-Myc expression.
|
26063074 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
To investigate the importance of the SUMO pathway in the context of cancer cell proliferation and tumor growth, we applied lentivirus-based short hairpin RNAs (shRNA) to knockdown SUMO pathway genes in human cancer cells. shRNAs for SAE2 and UBC9 reduced SUMO conjugation activity and inhibited proliferation of human cancer cells.
|
25860128 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
COM1 staining was compared with tumour staging.
|
23443904 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Structural basis of the interaction of the breast cancer oncogene LMO4 with the tumour suppressor CtIP/RBBP8.
|
23353824 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
COM-1/p8 acts as a tumour growth enhancer in colorectal cancer cell lines.
|
22493353 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
SAE2 is required for growth of Myc-dependent tumors in mice, and gene expression analyses of Myc-high human breast cancers suggest that low SAE1 and SAE2 abundance in the tumors correlates with longer metastasis-free survival of the patients.
|
22157079 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The transcript expression and protein distribution pattern in human colorectal carcinoma reveal a pivotal role of COM-1/p8 as a tumour suppressor.
|
20335521 |
2010 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In summary, a novel in vitro functional approach in ovarian cancer cells has identified RBBP8 as a gene for which both germline genetic variation and somatic alterations in tumours are associated with survival in ovarian cancer patients.
|
19270026 |
2009 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Gene-expression microarray analysis of RIMs (n = 5) compared to non-RIMs (MEN, n = 6) and a panel of other tumors (n = 62) showed that RIM gene-expression was similar to that seen in MEN, and by clustering analysis did not separate from them.
|
18604545 |
2008 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Several genes related to cell cycle regulation, such as CDK5RAP1, RBBP8, and SERTAD1, were up-regulated in these tumors.
|
19083478 |
2008 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In contrast, prostate cancer cells in tumour tissue showed substantially reduced Com-1 staining levels (p < 0.05 compared to normal cells for both cytoplasmic and nucleus staining), whereas the prostate cancer cell lines PC-3, DU145 and CA-HPV10 widely expressed Com-1.
|
17016631 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The potential tumour suppressive effect of Com-1 is at least partly via its interaction with PGC-1, the PPAR-gamma coactivator.
|
17089023 |
2006 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Two tandem BRCA1 C-terminal (BRCT) domains are essential for the tumor suppression activity of BRCA1 and interact in a phosphorylation-dependent manner with proteins involved in DNA damage-induced checkpoint control, including the DNA helicase BACH1 and the CtBP-interacting protein (CtIP).
|
16101277 |
2005 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
And whereas the mRNA levels of uPA and the uPA receptor were elevated in tumors from the patients who subsequently had poor outcome, no correlations were observed between tumor com1 mRNA expression and prognosis or histological and biochemical characteristics of the tumors.
|
10815897 |
2000 |