Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia
0.380 AlteredExpression phenotype BEFREE In conclusion, overexpression of TRPM3 and TRPV4 can jointly mediate the occurrence of mechanical hyperalgesia in TN. 31116130 2019
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia
0.380 Biomarker phenotype BEFREE The selective TRPV4 channel antagonist HC-067047 attenuates mechanical allodynia in diabetic mice. 31129158 2019
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia
0.380 Biomarker phenotype BEFREE The TRPV1 antagonist capsazepine, the selective TRPV4 antagonist HC-067047 and the calcium ions inhibitor ruthenium red were used to treat thermal and/or mechanical hyperalgesia. 29637027 2018
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia
0.380 Biomarker phenotype BEFREE Additionally, BK was able to sensitize TRPV4, thus contributing to mechanical hyperalgesia. 28283888 2018
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia
0.380 GeneticVariation phenotype BEFREE Among them there are TRP canonical 6 (TRPC6) and TRP vanilloid 4 (TRPV4) ion channels, which are known to cooperate in mechanical hyperalgesia. 27874267 2017
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia
0.380 Biomarker phenotype BEFREE These results suggest that prostanoids and PAR2 activation elicit TRPV1- and TRPA1-mediated spontaneous pain and TRPV4-mediated mechanical allodynia, respectively, independently of bacterial infection, following oral mucosal trauma. 28381109 2017
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia
0.380 AlteredExpression phenotype BEFREE PAR2 causes receptor-operated activation of TRPV4 channels and TRPV4 null mice have attenuated PAR2-stimulated neurogenic inflammation and mechanical hyperalgesia. 24779362 2014
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia
0.380 Biomarker phenotype CTD_human We also show that alpha2beta1 integrin and Src tyrosine kinase, which have been implicated in mechanical transduction, are important for the development of mechanical hyperalgesia, and that their contribution requires TRPV4. 18234883 2008
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia
0.380 Biomarker phenotype BEFREE Intraplantar injection of PAR2 agonist caused mechanical hyperalgesia in mice and sensitized pain responses to the TRPV4 agonists 4alphaPDD and hypotonic solutions. 17124270 2007