|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Importantly, we discovered that the membrane localization of SCP1 is crucial for impeding angiogenesis and tumor growth, and this localization depends on palmitoylation of a conserved cysteine motif within its NH2 terminus.
|
28440748 |
2017 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Collectively, our findings indicate that SCP1 is a potential tumor suppressor for liver cancers through dephosphorylating c-Myc Ser62.
|
25893300 |
2016 |
|
Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Furthermore, blocking PML degradation in ccRCC by SCP1 overexpression or Pin1 inhibition enhanced the tumor-suppressive effects of the mTOR inhibitor temsirolimus.
|
25293974 |
2014 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
SCP-1 was found in only one specimen and a several antigens could not been detected in any tumor tissue or cell line (MAGE-B, GAGE-1,2,8 and all 4 RAGE genes).
|
12584747 |
2003 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
The SCP-1-like gene and cTAGE-1 were shown to be immunogenic and immunologically tumor-specific and may therefore be candidates for immunotherapy targeting CTCL.
|
11149944 |
2001 |
|
Depressive Symptoms
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Significant associations (p < 4.2 × 10<sup>-3</sup>) after mediator adjustment were observed for single low-grade inflammation markers, including platelet distribution width (with PHQ9-6 and CD-RISC), granulocyte- and neutrophil-to-lymphocyte ratios, monocyte and lymphocyte fractions (with SF36-MCS).
|
31055172 |
2019 |
|
Depressive Symptoms
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Significant reductions in the IDDI (p < 0.001) and NDDI-E (p < 0.001) scores, improvements in the CD-RISC-10 (p < 0.001) and QOLIE-31 (p < 0.001) scores, and positive correlations between resilience levels and QOL (p < 0.01), as well as a negative correlation between depressive symptoms and resilience (p < 0.01) and QOL (p < 0.01), were observed after the psychotherapeutic intervention.
|
31574426 |
2019 |
|
Hypertensive disease
|
0.020 |
GeneticVariation
|
group |
BEFREE |
In the RISC cohort, the hepatic insulin resistance index was positively related with the risk of 3-year incident hypertension [standardized odds ratio: 1.54 (1.07-2.22); P = 0.02].
|
27984413 |
2017 |
|
psychological distress
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The participants were given the 10-item Kessler Psychological Distress Scale (K-10), Perceived Social Support Scale (PSSS) and Medical Coping Modes Questionnaire (MCMQ) to test the associates with CD-RISC-10 and obtain the cut-off of the scale.
|
28279394 |
2017 |
|
psychological distress
|
0.020 |
Biomarker
|
disease |
BEFREE |
The CD- RISC (25 item) was used to assess resilience and Kessler Psychological Distress Scale (K10) was used to assess psychological distress.
|
29078203 |
2017 |
|
Breast Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Primary MSCs as well as a MSC line (SCP-1) were cocultured with primary breast cancer cells, MCF-7, MDA-MB231 breast carcinoma or MCF-10A non-malignant breast epithelial cells or their conditioned medium.
|
24806942 |
2015 |
|
Hypertensive disease
|
0.020 |
AlteredExpression
|
group |
BEFREE |
We generated a mouse strain devoid of both CathA and Scpep1 activities (DD mice) and found that in response to high-salt diet and systemic injections of ET-1 these animals showed significantly increased blood pressure as compared to wild type mice or those with single deficiencies of CathA or Scpep1.
|
24586188 |
2014 |
|
Breast Carcinoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Here, we report that breast cancer associated exosomes contain microRNAs (miRNAs) associated with the RISC-Loading Complex (RLC) and display cell-independent capacity to process precursor microRNAs (pre-miRNAs) into mature miRNAs.
|
25446899 |
2014 |
|
Malignant neoplasm of testis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In 98 evaluable cases, SCP-1 and SSX-4 were expressed most frequently (both 65%), followed by HOM-TES-85/CT-8 (47%), GAGE (26%), SSX-1 (20%), NY-ESO-1 (13%), MAGE-3 (11%), SSX-2 (8%), CT-10 (7%), MAGE-4 (4%) and CT-7 (1%).
|
16094643 |
2006 |
|
Malignant neoplasm of testis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In order to define antigens that might be suitable as vaccines for pancreatic carcinoma, we investigated the composite expression of 10 cancer testis (CT) antigens (SCP-1, NY-ESO-1, SSX-1, SSX-2, SSX-4, GAGE, MAGE-3, MAGE-4, CT-7 and CT-8) by Reverse Transcriptase-PCR (RT-PCR) in fresh biopsies of human pancreatic adenocarcinoma, chronic pancreatitis and pancreatic carcinoma cell lines.
|
14991579 |
2004 |
|
Lymphoma, T-Cell, Cutaneous
|
0.020 |
Biomarker
|
disease |
BEFREE |
SCP-1 might serve as an additional diagnostic indicator in early and clinically indistinct lesions suspicious for cutaneous T-cell lymphoma.
|
11807795 |
2002 |
|
Lymphoma, T-Cell, Cutaneous
|
0.020 |
Biomarker
|
disease |
BEFREE |
The SCP-1-like gene and cTAGE-1 were shown to be immunogenic and immunologically tumor-specific and may therefore be candidates for immunotherapy targeting CTCL.
|
11149944 |
2001 |
|
Mental Depression
|
0.010 |
Biomarker
|
disease |
BEFREE |
Considering the application of the CD-RISC-10 in depression patients, the present study aimed to evaluate the psychometric properties, especially the measurement invariance, of the CD-RISC-10 in depressive patient sample.
|
31654919 |
2020 |
|
Depressive disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Considering the application of the CD-RISC-10 in depression patients, the present study aimed to evaluate the psychometric properties, especially the measurement invariance, of the CD-RISC-10 in depressive patient sample.
|
31654919 |
2020 |
|
Depressed mood
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Considering the application of the CD-RISC-10 in depression patients, the present study aimed to evaluate the psychometric properties, especially the measurement invariance, of the CD-RISC-10 in depressive patient sample.
|
31654919 |
2020 |
|
Major Depressive Disorder
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Confirmatory factor analysis (CFA) was conducted to evaluate the single-factor model of the CD-RISC-10 and the measurement equivalence of the CD-RISC-10 across the clinical (MDD) and non-clinical (undergraduate) samples, as well as gender invariance in the non-clinical sample.
|
31654919 |
2020 |
|
Arbovirus Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
Arbovirus infections are controlled by the RNAi machinery via the production of viral siRNAs and the formation of RISC complexes targeting viral genomes and mRNAs.
|
31354527 |
2019 |
|
Hyperglycemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
SCP-1 and SCP-2 also increased the activities of glutathione peroxidase (GSH-Px), catalase (CAT) and superoxide dismutase (SOD), as well as decreased the content of malondialdehyde (MDA) in the hyperglycemia mice.
|
30529353 |
2019 |
|
Temporomandibular Joint Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
As regards convergent validity, the PRS-C evidenced moderate-to-good relationships with the CD-RISC and the TSK-TMD.
|
29205436 |
2018 |
|
Diabetes
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The study population included 1246 people without diabetes (mean age 44 years, 55% women) from the EGIR-RISC population, a large European multicentre cohort.
|
27334352 |
2017 |