|
Hypertensive disease
|
0.010 |
Biomarker
|
group |
BEFREE |
(Optimizing Linkage and Retention to Hypertension Care in Rural Kenya [LARK]; NCT01844596).
|
31487546 |
2019 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
RBM4-regulated alternative splicing suppresses tumorigenesis.
|
25367940 |
2014 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
RBM4 inhibits cancer cell growth and migration by regulating cancer-associated gene splicing.
|
25367940 |
2014 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
RBM4 inhibits cancer cell growth and migration by regulating cancer-associated gene splicing.
|
25367940 |
2014 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
RBM4 cDNA probing of a cancer cDNA array involving 18 different tumor types from 13 different tissues and matching normal tissue found overexpression of RBM4 mRNA (p<0.01) in cervical, breast, lung, colon, ovarian and rectal cancers.
|
26898347 |
2016 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
RBM4 cDNA probing of a cancer cDNA array involving 18 different tumor types from 13 different tissues and matching normal tissue found overexpression of RBM4 mRNA (p<0.01) in cervical, breast, lung, colon, ovarian and rectal cancers.
|
26898347 |
2016 |
|
Rectal Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
RBM4 cDNA probing of a cancer cDNA array involving 18 different tumor types from 13 different tissues and matching normal tissue found overexpression of RBM4 mRNA (p<0.01) in cervical, breast, lung, colon, ovarian and rectal cancers.
|
26898347 |
2016 |
|
Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
RBM4 expression, together with tumor numbers, capsular formation, vascular invasion and Barcelona clinic liver cancer (BCLC) stage, was an independent prognostic factor for overall survival rate and disease-free survival rate of HCC.
|
28138257 |
2017 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
A xenograft tumor model was used to assess whether RBM4 inhibits GC growth in vivo.
|
31145716 |
2019 |
|
Malignant neoplasm of stomach
|
0.030 |
Biomarker
|
disease |
BEFREE |
A xenograft tumor model was used to assess whether RBM4 inhibits GC growth in vivo.
|
31145716 |
2019 |
|
Stomach Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
A xenograft tumor model was used to assess whether RBM4 inhibits GC growth in vivo.
|
31145716 |
2019 |
|
Malignant neoplasm of breast
|
0.020 |
Biomarker
|
disease |
BEFREE |
Elevated SRPK1 lessens apoptosis in breast cancer cells through RBM4-regulated splicing events.
|
25140042 |
2014 |
|
Breast Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Elevated SRPK1 lessens apoptosis in breast cancer cells through RBM4-regulated splicing events.
|
25140042 |
2014 |
|
Malformations of Cortical Development, Group II
|
0.010 |
Biomarker
|
disease |
BEFREE |
Finally, we showed that the full-length Dab1, but not exon 7/8-truncated Dab1, rescued neuronal migration defects in RBM4-depleted neurons, indicating that RBM4 plays a role in neuronal migration via modulating the expression of Dab1 splice isoforms.
|
29581187 |
2018 |
|
Malignant neoplasm of stomach
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Further, lower RBM4 expression is an independent prognostic marker for gastric cancer.
|
27324405 |
2016 |
|
Stomach Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Further, lower RBM4 expression is an independent prognostic marker for gastric cancer.
|
27324405 |
2016 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
In addition to providing mechanistic insights of cancer-related splicing dysregulation, this study establishes RBM4 as a tumor suppressor with therapeutic potential and clinical values as a prognostic factor.
|
25203323 |
2014 |
|
Esophageal Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
In situ hybridization and RNA immunoprecipitation assays demonstrated that TPM1-AS was located in the nucleus and interacted with RNA-binding motif protein 4 (RBM4) in human esophageal cancer cells.
|
28754317 |
2017 |
|
Esophageal carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In situ hybridization and RNA immunoprecipitation assays demonstrated that TPM1-AS was located in the nucleus and interacted with RNA-binding motif protein 4 (RBM4) in human esophageal cancer cells.
|
28754317 |
2017 |
|
Malignant neoplasm of esophagus
|
0.010 |
Biomarker
|
disease |
BEFREE |
In situ hybridization and RNA immunoprecipitation assays demonstrated that TPM1-AS was located in the nucleus and interacted with RNA-binding motif protein 4 (RBM4) in human esophageal cancer cells.
|
28754317 |
2017 |
|
Down Syndrome
|
0.010 |
Biomarker
|
disease |
LHGDN |
Manifold decreased protein levels of matrin 3, reduced motor protein HMP and hlark in fetal Down's syndrome brain.
|
12469345 |
2002 |
|
Liver carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our data implicate RBM4 as a novel prognostic marker and a potential therapeutic target for HCC.
|
28138257 |
2017 |
|
Tauopathies
|
0.010 |
AlteredExpression
|
group |
LHGDN |
Our work also suggests that down-regulating tau exon 10 splicing activators, such as RBM4, may be of therapeutic potential in tauopathies involving excessive tau exon 10 inclusion.
|
16777844 |
2006 |
|
Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
RBM4 cDNA probing of a cancer cDNA array involving 18 different tumor types from 13 different tissues and matching normal tissue found overexpression of RBM4 mRNA (p<0.01) in cervical, breast, lung, colon, ovarian and rectal cancers.
|
26898347 |
2016 |
|
Tumor Cell Invasion
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Re-expression of RBM4 inhibited the proliferation, migration, and invasion of GC cells, while promoting apoptosis.
|
31145716 |
2019 |