|
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Lymphoma cell lines harboring the t(11;14) showed cyclin D1 protein but no or very low levels of cyclin D3; three other B-cell lines, a T-cell line, and peripheral blood lymphocytes strongly expressed cyclin D3 and reacted negatively for cyclin D1.
|
9376597 |
1997 |
|
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cyclin D1 positive diffuse large B-cell lymphoma is a post-germinal center-type lymphoma without alterations in the CCND1 gene locus.
|
21281227 |
2011 |
|
Adult Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Cyclin D1 overexpression is a hallmark of mantle cell lymphoma, whereas cyclins D2 and D3 have not been shown to be closely associated with any particular subtype of lymphoma.
|
21790895 |
2011 |
|
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cyclin D1-positive large B-cell lymphoma is rare, but as large B-cell lymphoma is a common type of lymphoma, cyclin D1-positive large B-cell lymphoma should be considered a major possibility during differential diagnosis, including in the tonsils.
|
28296741 |
2017 |
|
Adult Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Aberrant Cyclin D1 expression seems to promote proliferation in other types of lymphoma, while a growth promoting CCND1/TACSD1(TROP2) fusion product has also been described in tumors.
|
19554511 |
2009 |
|
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Accordingly, cyclin-D1 inhibition sensitized the lymphoma cells to apoptosis through BAX release.
|
21746927 |
2011 |
|
Adult Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Accordingly, this isotype was the most effective in eradicating BCL1 lymphoma but had limited efficacy in s.c. tumors.
|
29109120 |
2017 |
|
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
All 1292 reactive lymph nodes from unselected consecutive surgical specimens of 131 patients without a history of lymphoma obtained over a 3-month period were stained for cyclin D1.
|
22790016 |
2012 |
|
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Among the 23 validated genes were cyclin D1 (CCND1) and B-cell CLL/lymphoma 2, which have well-known roles in lymphoma pathogenesis.
|
14961037 |
2004 |
|
Adult Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemical expression of PRAD1/cyclin D1 protein has been investigated in 106 tissue specimens of 104 cases of lymphoma, non-neoplastic lymphoid disorders and other hematologic malignancies by employing the monoclonal antibody 5D4 with formalin-fixed paraffin-embedded sections, using the microwave oven heating method.
|
7531681 |
1994 |
|
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Immunophenotypic analysis showed that the lymphoma cells were positive for cyclin D1 (n=16/16), Myc (9/11), and P53 (n=9/9).
|
27776009 |
2017 |
|
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In human blood cancers, loss of Rb expression has been widely reported in both acute myeloblastic and acute lymphoblastic leukemias, cyclin D1 amplification is common in mantle cell lymphoma, and silencing of the p16/INK4a tumor suppressor gene occurs frequently in AML and various types of lymphoma.
|
15611658 |
2005 |
|
Adult Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In parallel, we investigated the relationship between p27(Kip1), the lymphoma proliferation index, Epstein-Barr virus status, expression of cellular cyclin D3 and cyclin D1, and B-cell differentiation stage.
|
12107101 |
2002 |
|
Adult Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In particular, the recognition of chromosomal translocations which have activated the BCL1 and BCL2 proto-oncogenes have strong associations with specific types of non-Hodgkin's malignant lymphomas such as mantle cell lymphoma and follicular center cell lymphoma, respectively.
|
8852399 |
1995 |
|
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the present study, we analysed 34 de novo diffuse large B cell lymphoma (DLCL) from a population-based lymphoma registry for alterations of the RB1 pathway at the genetic (RB1 and CDK4) and protein (pRb, cyclin D1, cyclin D3, CDK4, and E2F-1) level.
|
10803523 |
2000 |
|
Adult Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
None of the known lymphoma-associated chromosomal changes or rearrangements of the BCL1, BCL2, BCL3, BCL6, and CMYC genes were detected.
|
8547655 |
1996 |
|
Adult Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our results show that cyclin-D2 and D3 proteins are expressed in many more lymphoma subtypes than cyclin-D1.
|
20062012 |
2010 |
|
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Rearrangement of bcl-1 has yet to be associated with a specific group of lymphoma.
|
2250191 |
1990 |
|
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Statistical analysis of the expression data revealed the combination of CCND1 and CDK4 as the best classifier concerning separation of both lymphoma types.
|
12036888 |
2002 |
|
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The latter parameters and IPI were the only ones with independent prognostic value (RR = 10, 5.0, 6.7, and 3.7, respectively; P < 0.001) when assessed together with lymphoma sub-type, primary versus relapse cases, treatment, B symptoms, S phase fraction, and presence of BCL1 and BCL2 translocations.
|
11747333 |
2001 |
|
Adult Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The mRNA and protein expression levels of B cell leukemia/lymphoma (Bcl‑2), Bcl‑2 associated X (Bax), cyclin dependent kinase 4 (CDK4), cyclin D1 and p21 were evaluated using reverse transcription‑polymerase chain reaction and western blot analysis, respectively.
|
29115462 |
2018 |
|
Adult Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The nuclear staining pattern was not observed with other types of lymphoma and thus may correlate with PRAD1 mRNA overexpression.
|
7961120 |
1994 |
|
Adult Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The protein synthesis inhibitor silvestrol has potent activity in B-cell leukemias via the mitochondrial pathway of apoptosis, and also reduces cyclin D1 expression in breast cancer and lymphoma cell lines.
|
22791882 |
2012 |
|
Adult Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results indicate that rearrangement of the BCL1 locus may be closely associated with ILL and could be considered as a genotypic marker of this lymphoma subtype.
|
2078513 |
1990 |
|
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, bcl-1 and PRAD1 rearrangement is strongly associated with centrocytic lymphoma, providing a useful molecular marker for classifying this subtype of lymphoma and suggesting an important role for PRAD1 cyclin D1 in the pathogenesis of this neoplasm.
|
1394169 |
1992 |