|
Squamous cell carcinoma of esophagus
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
There appears to be an influence of CCND1 G870A/G1772C genotypes on genetic susceptibility to ESCC.
|
21268129 |
2011 |
|
Squamous cell carcinoma of esophagus
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this study, we clarified the clinical significance of FBXO31 and characterized the association between cyclin D1 and FBXO31 in ESCC cases.
|
21537837 |
2011 |
|
Squamous cell carcinoma of esophagus
|
0.400 |
Biomarker
|
disease |
BEFREE |
Prediction of CCND1 amplification using plasma DNA is thought to be a promising prognostic biomarker in ESCC patients.
|
20389301 |
2010 |
|
Squamous cell carcinoma of esophagus
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here we identify that Wnt2/beta-catenin signaling pathway is activated in ESCC cells, and sodium nitroprusside (SNP) and siRNA against beta-catenin not only inhibit the expressions of beta-catenin and its major downstream effectors including c-myc and cyclin D1, but induce cell cycle arrest and apoptosis, suggesting that Wnt2/beta-catenin pathway may be a potential molecular target for ESCC therapy.
|
19857041 |
2010 |
|
Squamous cell carcinoma of esophagus
|
0.400 |
Biomarker
|
disease |
BEFREE |
Using Q-RT-PCR to measure cyclin D1, TS, TP, DPD, and Her-2/neu as predictors for response, survival, and recurrence in patients with esophageal squamous cell carcinoma following radiochemotherapy.
|
18704459 |
2009 |
|
Squamous cell carcinoma of esophagus
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Human ESCC cell line EC109 was cultured with aspirin and cigarette smoke extract (CSE) at different concentrations for 48 h. Cell growth was tested with 3-(4,5-dimethylthiazol-2-Yl)-2,5-diphenyltetrazolium bromide reduction assay; cyclin D(1) mRNA level was detected by reverse transcription-polymerase chain reaction assays; protein level of cyclin D(1) was detected by Western blot; the cell cycle change was monitored by flow cytometry detection assays.
|
19207549 |
2009 |
|
Squamous cell carcinoma of esophagus
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, LCM coupled with real-time fluorescence quantitative-PCR technique is more precise than PCR for the identifying amplified oncogenes; The role of CCND1 amplification in ESCC development and progression needs more extensive study.
|
17498553 |
2007 |
|
Squamous cell carcinoma of esophagus
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Finally, the stable transfection of RRIG1 inhibited esophageal SCC cell growth and the expression of extracellular signal-regulated protein kinases 1 and 2 and cell cycle-related genes (e.g., cyclin D1, phosphorylated Rb, and E2F).
|
17308098 |
2007 |
|
Squamous cell carcinoma of esophagus
|
0.400 |
Biomarker
|
disease |
BEFREE |
Influence of apoptosis (BCL2, FAS), cell cycle (CCND1) and growth factor (EGF, EGFR) genetic polymorphisms on survival outcome: an exploratory study in squamous cell esophageal cancer.
|
17912028 |
2007 |
|
Squamous cell carcinoma of esophagus
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In this study, we investigated the expression pattern of beta-catenin and cyclin D1 using immunohistochemistry and searched for mutations in exon 3 of the beta-catenin gene and Axin gene in esophageal squamous cell carcinoma.
|
17309796 |
2007 |
|
Squamous cell carcinoma of esophagus
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The frequency of CCND1 amplification and p16 homozygous deletion is suggested to be associated with ESCC progression.
|
17016592 |
2006 |
|
Squamous cell carcinoma of esophagus
|
0.400 |
Biomarker
|
disease |
BEFREE |
TAOS1 overexpression was observed in 7 out of 38 (18%) esophageal SCCs and CCND1 overexpression was observed in 4 out of 38 (11%), suggesting that TAOS1 was more frequently overexpressed than CCND1 in esophageal SCC.
|
16827140 |
2006 |
|
Squamous cell carcinoma of esophagus
|
0.400 |
Biomarker
|
disease |
BEFREE |
The purpose of this study was to clarify the relationship of E2F1 and cyclin D1 in ESCC.
|
16053486 |
2005 |
|
Squamous cell carcinoma of esophagus
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Epidermal growth factor receptor and cyclin D1 are independently amplified and overexpressed in esophageal squamous cell carcinoma.
|
15672286 |
2005 |
|
Squamous cell carcinoma of esophagus
|
0.400 |
Biomarker
|
disease |
BEFREE |
In situ hybridization and immunohistochemistry were used respectively to detect the expression of mRNA and proteins of Egr-1, c-fos and cyclin D1 in 70 cases of esophageal squamous cell carcinoma and their corresponding para-cancerous mucosa and upper cut edge mucosa.
|
14966901 |
2004 |
|
Squamous cell carcinoma of esophagus
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Determination of the cyclin D1 (G870A) single nucleotide polymorphism may be suitable to identify individuals with increased risk for ESCC or CAC in the northern Chinese population.
|
12673692 |
2003 |
|
Squamous cell carcinoma of esophagus
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We investigated whether the putative transforming gene MYEOV, mapping 360 kb centromeric to CCND1 and activated concomitantly with CCND1 in a subset of t(11;14)(q13;q32) positive multiple myeloma cell lines, represents a target of 11q13 amplification in ESC.
|
12202983 |
2002 |
|
Squamous cell carcinoma of esophagus
|
0.400 |
Biomarker
|
disease |
BEFREE |
Seventeen (34%) of the 50 ESCC primary lesions were cyclin D1-positive, while 33 (66%) were cyclin D1-negative.
|
11295092 |
2001 |
|
Squamous cell carcinoma of esophagus
|
0.400 |
Biomarker
|
disease |
BEFREE |
Immunoreactivities of cyclin D1 and pRB were evaluated in 148 surgically resected ESCC by use of monoclonal antibodies.
|
11570573 |
2001 |
|
Squamous cell carcinoma of esophagus
|
0.400 |
Biomarker
|
disease |
BEFREE |
We immunohistochemically examined p57KIP2 (p57) expression in 92 patients with human esophageal squamous cell carcinoma (SCC) to determine the relationship between this expression and those of cyclin D1 and E. The p57 labeling index (LI) (defined as the percentage of p57-positive cells) in esophageal SCC was 43.3 +/- 3.2% (mean +/- standard error of the mean).
|
10928132 |
2000 |
|
Squamous cell carcinoma of esophagus
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
DNA ploidy pattern, Ki-67 labeling index (LI), and cyclin D1 and p53 protein expression were examined and detailed pathologic examinations were conducted on tumors from 53 patients (46 males and 7 females with a mean age of 66 years [range, 47-85 years]) with surgically resected esophageal squamous cell carcinoma and the prognostic value of these factors was evaluated.
|
10526265 |
1999 |
|
Squamous cell carcinoma of esophagus
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
An amplification/overexpression of the CCND1 gene plays an important role in the enhancement of cell transformation in esophageal squamous cell carcinoma cells.
|
10568815 |
1999 |
|
Squamous cell carcinoma of esophagus
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Altered p16/MTS1/CDKN2 and cyclin D1/PRAD-1 gene expression is associated with the prognosis of squamous cell carcinoma of the esophagus.
|
9815619 |
1997 |
|
Squamous cell carcinoma of esophagus
|
0.400 |
Biomarker
|
disease |
BEFREE |
Amplification of cyclin D1 was detected in 28 (23%) of 122 cases of squamous cell carcinoma of the esophagus.
|
9816282 |
1996 |
|
Squamous cell carcinoma of esophagus
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Previous studies have found a 3-10-fold amplification and overexpression of the cyclin D1 gene in about 32% of human esophageal squamous cell carcinoma.
|
8781742 |
1996 |