Squamous cell carcinoma of the head and neck
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The purpose of this study was to investigate the expression pattern of ZNF703 in HNSCC in association with CCND1 expression and Akt phosphorylation.
|
31574205 |
2019 |
Squamous cell carcinoma of the head and neck
|
0.400 |
Biomarker
|
disease |
BEFREE |
Nine studies met inclusion criteria.Quantitative evaluation indicated strong statistically significant association between CCND1/cyclin D1 amplification/overexpression and the progression of head and neck PMD to head and neck squamous cell carcinoma (risk ratio [RR] = 2.04, 95% confidence interval [CI] = 1.37-3.03, P < .001, and RR = 2.27, 95% CI = 1.32-3.91, P = .003, respectively).
|
31184805 |
2019 |
Squamous cell carcinoma of the head and neck
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Two of the hub genes (PCNA and CCND1) identified from the PPI network of component DEGs in cell cycle and p53 signaling pathways were defined as the critical targets of candidate drugs with increased protein expression in HNSCC tissues, which was reported by the human protein atlas (HPA) database and cBioPortal.
|
30871913 |
2019 |
Squamous cell carcinoma of the head and neck
|
0.400 |
Biomarker
|
disease |
CTD_human |
This was verified by IHC staining of CCND1 from HNSCC patients.
|
29464035 |
2018 |
Squamous cell carcinoma of the head and neck
|
0.400 |
Biomarker
|
disease |
BEFREE |
Expression of p53, EGFR, p16 and Cyclin-D1 in non-oropharyngeal HNSCC in Ghana is largely similar to what has been reported in published studies from other countries.
|
30138436 |
2018 |
Squamous cell carcinoma of the head and neck
|
0.400 |
Biomarker
|
disease |
BEFREE |
This was verified by IHC staining of CCND1 from HNSCC patients.
|
29464035 |
2018 |
Squamous cell carcinoma of the head and neck
|
0.400 |
Biomarker
|
disease |
CTD_human |
Deletion of CDKN2A (p16) or amplification of CCND1 (cyclin D1) occurs commonly in head and neck squamous cell carcinoma (HNSCC) and induces sustained cyclin-dependent kinase (CDK) 4/6 activation.
|
26909611 |
2016 |
Squamous cell carcinoma of the head and neck
|
0.400 |
Biomarker
|
disease |
BEFREE |
These findings demonstrate that TRUE gene silencing of cyclin D1 leads to inhibition of the growth of HNSCC cells and suggest that these sgRNAs alone or combined with cisplatin may be a useful new therapy for HNSCCs.
|
25437003 |
2014 |
Squamous cell carcinoma of the head and neck
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
While aberrant expression of cyclin-dependent kinase-4 (CDK4) has been found in squamous cell carcinoma of the head and neck (SCCHN), the associations between CDK4 and its regulators, namely, cyclin D1, cyclin E, gankyrin, SEI1, and BMI1 in gene expression remain to be explored.
|
24982332 |
2014 |
Squamous cell carcinoma of the head and neck
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest the prognostic value of CCND1 amplification and cyclin D1 expression for patients with OSCC and highlight the genetic differences in HNSCC of different subanatomic localisation.
|
23494454 |
2014 |
Squamous cell carcinoma of the head and neck
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Consistent with the in vitro findings, immunostaining of HNSCC patient samples revealed that high levels p16INK4a expression significantly correlated with decreased cyclin D1 expression.
|
24473065 |
2014 |
Squamous cell carcinoma of the head and neck
|
0.400 |
Biomarker
|
disease |
BEFREE |
The current study aims to investigate whether there is a crosstalk between these pathways in HNSCC and which pathway is more likely to regulate cyclin D1.
|
23730900 |
2014 |
Squamous cell carcinoma of the head and neck
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Real-time PCR and immunohistochemistry were used to evaluate EZH2 and cyclin D1 expression in 46 HNSCC samples, and the expression levels also were re-evaluated in 124 independent samples by immunohistochemistry.
|
21989926 |
2012 |
Squamous cell carcinoma of the head and neck
|
0.400 |
Biomarker
|
disease |
BEFREE |
Cyclin D1 was silenced in an HNSCC cell line and its effect tested in sensitizing the cells to cisplatin, in vitro as well as in vivo.
|
22213296 |
2012 |
Squamous cell carcinoma of the head and neck
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
By grouping patients according to stage and radiation treatment, we compared SCCHN survival with regard to ERCC2 A35931C (Lys751Gln, rs13181) and CCND1 G870A (Pro241Pro, rs9344) genotypes.
|
21890746 |
2011 |
Squamous cell carcinoma of the head and neck
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The CCND1 G870A polymorphism has been associated with an increased susceptibility to squamous cell carcinoma of the head and neck, bladder, prostate, and gastric cardiac cancers.
|
22812184 |
2011 |
Squamous cell carcinoma of the head and neck
|
0.400 |
Biomarker
|
disease |
BEFREE |
This study suggests the participation of pAkt, NF-κB and cyclin D1 in the invasion process of head and neck squamous cell carcinoma.
|
20969630 |
2011 |
Squamous cell carcinoma of the head and neck
|
0.400 |
Biomarker
|
disease |
BEFREE |
Subsequent mRNA expression analysis of 11q13 candidate genes CCND1 and CTTN revealed that HNSCC cell lines exhibiting a DNA copy number gain on 11q13 had a higher transcript level of CCND1 and CTTN compared with HNSCC cell lines without 11q13 copy number gain (P = 0.014 and P = 0.009, respectively).
|
20149059 |
2010 |
Squamous cell carcinoma of the head and neck
|
0.400 |
Biomarker
|
disease |
BEFREE |
Recently, amplification of PPFIA1, encoding a member of the liprin family located about 600 kb telomeric to CCND1 on chromosome band 11q13, was described in squamous cell carcinoma of head and neck.
|
19787783 |
2010 |
Squamous cell carcinoma of the head and neck
|
0.400 |
Biomarker
|
disease |
BEFREE |
In a population-based case-control study of 698 cases and 777 controls, we both genotyped all participants for the CCND1 gene and did immunohistochemical staining of the cyclin D1 protein in the HNSCC tumors.
|
18413827 |
2008 |
Squamous cell carcinoma of the head and neck
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Both CTTN and CCND1, the latter encoding the cell cycle regulator cyclin D1, reside at chromosomal locus 11q13, a region commonly amplified in breast cancers and head and neck squamous cell carcinoma (HNSCC).
|
17909038 |
2007 |
Squamous cell carcinoma of the head and neck
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Amplification of 11q13 DNA sequences and overexpression of CCND1 are common findings in head and neck squamous cell carcinoma (HNSCC), identified in about 30% of the cases.
|
17065789 |
2006 |
Squamous cell carcinoma of the head and neck
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In a xenograft model of squamous cell carcinoma of the head and neck (SCCHN), daily administration of the STAT3 decoy (25 microg) resulted in decreased tumor volumes, abrogation of STAT3 activation, and decreased expression of STAT3 target genes (VEGF, Bcl-xL, and cyclin D1) compared to treatment with a mutant control decoy.
|
15592503 |
2005 |
Squamous cell carcinoma of the head and neck
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Molecular studies of squamous cell carcinoma of the head and neck (HNSCC) have demonstrated multiple genetic abnormalities such as activation of various oncogenes (Ras, Myc, epidermal growth factor receptor, and cyclin D1), tumor suppressor gene inactivation (TP53 and p16), and loss of heterozygosity at numerous chromosomal locations.
|
14729608 |
2004 |
Squamous cell carcinoma of the head and neck
|
0.400 |
Biomarker
|
disease |
BEFREE |
Detection of CCND1 amplification using FISH may be a useful marker of sensitivity to NAC and chemoradiotherapy for HNSCC.
|
14981992 |
2004 |