CCND1, cyclin D1, 595

N. diseases: 859; N. variants: 12
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Squamous cell carcinoma of the head and neck
0.400 AlteredExpression disease BEFREE The purpose of this study was to investigate the expression pattern of ZNF703 in HNSCC in association with CCND1 expression and Akt phosphorylation. 31574205 2019
Squamous cell carcinoma of the head and neck
0.400 Biomarker disease BEFREE Nine studies met inclusion criteria.Quantitative evaluation indicated strong statistically significant association between CCND1/cyclin D1 amplification/overexpression and the progression of head and neck PMD to head and neck squamous cell carcinoma (risk ratio [RR] = 2.04, 95% confidence interval [CI] = 1.37-3.03, P < .001, and RR = 2.27, 95% CI = 1.32-3.91, P = .003, respectively). 31184805 2019
Squamous cell carcinoma of the head and neck
0.400 AlteredExpression disease BEFREE Two of the hub genes (PCNA and CCND1) identified from the PPI network of component DEGs in cell cycle and p53 signaling pathways were defined as the critical targets of candidate drugs with increased protein expression in HNSCC tissues, which was reported by the human protein atlas (HPA) database and cBioPortal. 30871913 2019
Squamous cell carcinoma of the head and neck
0.400 Biomarker disease CTD_human This was verified by IHC staining of CCND1 from HNSCC patients. 29464035 2018
Squamous cell carcinoma of the head and neck
0.400 Biomarker disease BEFREE Expression of p53, EGFR, p16 and Cyclin-D1 in non-oropharyngeal HNSCC in Ghana is largely similar to what has been reported in published studies from other countries. 30138436 2018
Squamous cell carcinoma of the head and neck
0.400 Biomarker disease BEFREE This was verified by IHC staining of CCND1 from HNSCC patients. 29464035 2018
Squamous cell carcinoma of the head and neck
0.400 Biomarker disease CTD_human Deletion of CDKN2A (p16) or amplification of CCND1 (cyclin D1) occurs commonly in head and neck squamous cell carcinoma (HNSCC) and induces sustained cyclin-dependent kinase (CDK) 4/6 activation. 26909611 2016
Squamous cell carcinoma of the head and neck
0.400 Biomarker disease BEFREE These findings demonstrate that TRUE gene silencing of cyclin D1 leads to inhibition of the growth of HNSCC cells and suggest that these sgRNAs alone or combined with cisplatin may be a useful new therapy for HNSCCs. 25437003 2014
Squamous cell carcinoma of the head and neck
0.400 AlteredExpression disease BEFREE While aberrant expression of cyclin-dependent kinase-4 (CDK4) has been found in squamous cell carcinoma of the head and neck (SCCHN), the associations between CDK4 and its regulators, namely, cyclin D1, cyclin E, gankyrin, SEI1, and BMI1 in gene expression remain to be explored. 24982332 2014
Squamous cell carcinoma of the head and neck
0.400 AlteredExpression disease BEFREE Our results suggest the prognostic value of CCND1 amplification and cyclin D1 expression for patients with OSCC and highlight the genetic differences in HNSCC of different subanatomic localisation. 23494454 2014
Squamous cell carcinoma of the head and neck
0.400 AlteredExpression disease BEFREE Consistent with the in vitro findings, immunostaining of HNSCC patient samples revealed that high levels p16INK4a expression significantly correlated with decreased cyclin D1 expression. 24473065 2014
Squamous cell carcinoma of the head and neck
0.400 Biomarker disease BEFREE The current study aims to investigate whether there is a crosstalk between these pathways in HNSCC and which pathway is more likely to regulate cyclin D1. 23730900 2014
Squamous cell carcinoma of the head and neck
0.400 AlteredExpression disease BEFREE Real-time PCR and immunohistochemistry were used to evaluate EZH2 and cyclin D1 expression in 46 HNSCC samples, and the expression levels also were re-evaluated in 124 independent samples by immunohistochemistry. 21989926 2012
Squamous cell carcinoma of the head and neck
0.400 Biomarker disease BEFREE Cyclin D1 was silenced in an HNSCC cell line and its effect tested in sensitizing the cells to cisplatin, in vitro as well as in vivo. 22213296 2012
Squamous cell carcinoma of the head and neck
0.400 GeneticVariation disease BEFREE By grouping patients according to stage and radiation treatment, we compared SCCHN survival with regard to ERCC2 A35931C (Lys751Gln, rs13181) and CCND1 G870A (Pro241Pro, rs9344) genotypes. 21890746 2011
Squamous cell carcinoma of the head and neck
0.400 GeneticVariation disease BEFREE The CCND1 G870A polymorphism has been associated with an increased susceptibility to squamous cell carcinoma of the head and neck, bladder, prostate, and gastric cardiac cancers. 22812184 2011
Squamous cell carcinoma of the head and neck
0.400 Biomarker disease BEFREE This study suggests the participation of pAkt, NF-κB and cyclin D1 in the invasion process of head and neck squamous cell carcinoma. 20969630 2011
Squamous cell carcinoma of the head and neck
0.400 Biomarker disease BEFREE Subsequent mRNA expression analysis of 11q13 candidate genes CCND1 and CTTN revealed that HNSCC cell lines exhibiting a DNA copy number gain on 11q13 had a higher transcript level of CCND1 and CTTN compared with HNSCC cell lines without 11q13 copy number gain (P = 0.014 and P = 0.009, respectively). 20149059 2010
Squamous cell carcinoma of the head and neck
0.400 Biomarker disease BEFREE Recently, amplification of PPFIA1, encoding a member of the liprin family located about 600 kb telomeric to CCND1 on chromosome band 11q13, was described in squamous cell carcinoma of head and neck. 19787783 2010
Squamous cell carcinoma of the head and neck
0.400 Biomarker disease BEFREE In a population-based case-control study of 698 cases and 777 controls, we both genotyped all participants for the CCND1 gene and did immunohistochemical staining of the cyclin D1 protein in the HNSCC tumors. 18413827 2008
Squamous cell carcinoma of the head and neck
0.400 GeneticVariation disease BEFREE Both CTTN and CCND1, the latter encoding the cell cycle regulator cyclin D1, reside at chromosomal locus 11q13, a region commonly amplified in breast cancers and head and neck squamous cell carcinoma (HNSCC). 17909038 2007
Squamous cell carcinoma of the head and neck
0.400 AlteredExpression disease BEFREE Amplification of 11q13 DNA sequences and overexpression of CCND1 are common findings in head and neck squamous cell carcinoma (HNSCC), identified in about 30% of the cases. 17065789 2006
Squamous cell carcinoma of the head and neck
0.400 AlteredExpression disease BEFREE In a xenograft model of squamous cell carcinoma of the head and neck (SCCHN), daily administration of the STAT3 decoy (25 microg) resulted in decreased tumor volumes, abrogation of STAT3 activation, and decreased expression of STAT3 target genes (VEGF, Bcl-xL, and cyclin D1) compared to treatment with a mutant control decoy. 15592503 2005
Squamous cell carcinoma of the head and neck
0.400 AlteredExpression disease BEFREE Molecular studies of squamous cell carcinoma of the head and neck (HNSCC) have demonstrated multiple genetic abnormalities such as activation of various oncogenes (Ras, Myc, epidermal growth factor receptor, and cyclin D1), tumor suppressor gene inactivation (TP53 and p16), and loss of heterozygosity at numerous chromosomal locations. 14729608 2004
Squamous cell carcinoma of the head and neck
0.400 Biomarker disease BEFREE Detection of CCND1 amplification using FISH may be a useful marker of sensitivity to NAC and chemoradiotherapy for HNSCC. 14981992 2004