|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
NEFA and glycerol concentrations were inversely correlated with RBP4/retinol in children with obesity but not in those without obesity.
|
30773418 |
2020 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Visfatin is highly expressed in visceral fat with stimulatory effect on osteoblast proliferation and inhibition on osteoclast formation, while RBP-4 acts as a transporter protein for retinol, associated with changes in insulin sensitivity, independent of obesity, with no consensus on its effect on bone metabolism.
|
31054116 |
2019 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
<b>Context:</b> Retinol-binding protein 4 <b>(</b>RBP4) is associated with visceral fat and insulin resistance (IR) in obesity, type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease (NAFLD), but some of these data remain controversial.
|
31588816 |
2019 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Retinol binding protein 4 (RBP4), mainly secreted by the liver and adipocytes, is a transporter of vitamin A. RBP4 has been shown to be involved in several pathophysiological processes, such as obesity, insulin resistance, and cardiovascular risk.
|
31412686 |
2019 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Proteins involved in inflammation (fibrinogen alpha (FIBA), serotransferrin (TRFE, and kininogen-1 (KNG1)) and insulin resistance (ADP-ribosylation factor (ARF)-like protein 15 (ARL15) and retinol-binding protein 4 (RET4)) were found to be significantly increased in the urine samples of MUHO compared to MHO patients.
|
31623319 |
2019 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Retinol binding protein 4 (RBP4), a protein secreted by adipocytes and bound in plasma to transthyretin (TTR), has been associated with obesity, the early phase of insulin resistance, metabolic syndrome, and type 2 diabetes mellitus.
|
29747616 |
2018 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Because RBP4 is elevated in obesity and associates with the development of glucose intolerance and insulin resistance, we tested whether a liver-specific overexpression of RBP4 in mice impairs glucose homeostasis.
|
30126844 |
2018 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
We aimed to test serum RBP4 in healthy non-obese individuals and in patients with well-characterized phenotype: obesity without confounding effects of diabetes, metabolic syndrome or dyslipidaemia.
|
29786448 |
2018 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Retinol binding protein 4 (RBP4) is an adipokine that drives the development of hyperinsulinemia and type II diabetes in obesity patients and animals.
|
29642915 |
2018 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
RBP4 and leptin can be considered as possible GCF and serum markers of inflammatory activity in CP and obesity, which further longitudinal studies are needed.
|
27933445 |
2017 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Increased plasma retinol-binding protein 4 (RBP4), a novel adipokine, has been associated in previous studies with obesity, type 2 diabetes, dyslipidemia, hypertension (HT), atherosclerosis, and coronary artery disease.
|
28038989 |
2017 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
The association between RBP-4 and abdominal obesity was not significant in both unadjusted and adjusted models.
|
28279688 |
2017 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Association of RBP4 SNPs with obesity, metabolic risk factors (blood pressure, triglycerides, high-density lipoprotein cholesterol, insulin resistance) and markers of vascular inflammation, such as high-sensitive C-reactive protein (hs-CRP), was tested.
|
26611784 |
2016 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggested that variations in the RBP4 gene were correlated with BMI and polymorphisms more likely could contribute to the development of obesity in our population.
|
25701600 |
2015 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Serum retinol-binding protein 4 (RBP4) is the sole specific transport protein for retinol in the blood, but it is also an adipokine with retinol-independent, proinflammatory activity associated with obesity, insulin resistance, type 2 diabetes, and cardiovascular disease.
|
26055327 |
2015 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Insulin resistance and obesity is influenced by the retinol binding protein 4 (RBP4) adipokine.
|
25479076 |
2014 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Retinol-binding protein 4 (RBP4) is closely associated with a variety of abnormal glycolipid metabolism diseases such as insulin resistance, obesity, diabetes mellitus, and metabolic syndrome.
|
23420326 |
2013 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Adipokine screening in fARKO mice revealed a selective increase in plasma and intra-adipose retinol binding protein 4 (RBP4) that preceded obesity.
|
22415878 |
2012 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Studies in adults identified the -803 G>A promoter polymorphism (rs3758539) in the RBP4 gene (RBP4) as a functional variant conferring an increased risk for obesity and type 2 diabetes.
|
22068556 |
2011 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
In adults, elevated levels of retinol binding protein 4 (RBP4) have been associated with biochemical markers of adiposity-related co-morbidities including insulin resistance, dyslipidemia, hypertension, and abdominal obesity.
|
22308842 |
2011 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
RBP4 has been associated with insulin resistance and hypertriglyceridemia in obesity, the metabolic syndrome and type 2 diabetes.
|
19765959 |
2010 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Due to the infiltration of adipose tissue in obesity by macrophages derived from circulating monocytes and, on the other hand, the existence of a close genetic relationship between adipocytes and macrophages, we decided to examine if RBP4 is expressed in monocytes and/or primary human macrophages.
|
19537932 |
2010 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Since the role of adipokine retinol-binding protein-4 (RBP4) in obesity remains uncertain and its relationship with other adipokines and inflammatory markers has not been examined in detail, we investigated the relationships of RBP4 mRNA expression and circulating protein levels with obesity, anthropometric and metabolic variables, as well as with obesity-related inflammatory markers adiponectin and C-reactive protein.
|
19369430 |
2009 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
We examined the relationship between plasma RBP4 levels, expression of RBP4 in skeletal muscle and adipose tissue, and insulin sensitivity in Mexican Americans with varying degrees of obesity and glucose tolerance.
|
19190263 |
2009 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
To better understand the molecular mechanisms underlying fenofibrate action, we investigated whether fenofibrate affects serum levels of retinol-binding protein-4 (RBP4), an adipocytokine that has recently been shown to link obesity and insulin resistance.
|
19088257 |
2009 |