Cancer-Associated Retinopathy
|
0.050 |
Biomarker
|
disease |
BEFREE |
Cancer-associated retinopathy (CAR) is an ocular manifestation of a paraneoplastic syndrome whereby immunological reactions toward recoverin, a retina-specific calcium binding protein, and other retinal antigens aberrantly expressed in tumor cells are elicited.
|
19887879 |
2010 |
Cancer-Associated Retinopathy
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Establishment of a novel small cell lung carcinoma cell line with specific recoverin expression from a patient with cancer-associated retinopathy.
|
17374419 |
2007 |
Cancer-Associated Retinopathy
|
0.050 |
Biomarker
|
disease |
BEFREE |
Autoantibodies against recoverin are found in the sera of patients with cancer-associated retinopathy syndrome, a paraneoplastic disease associated with retinal degeneration.
|
12935781 |
2003 |
Cancer-Associated Retinopathy
|
0.050 |
Biomarker
|
disease |
BEFREE |
Our results support the hypothesis that, in cancer-associated retinopathy (CAR) patients, auto-immune antibody targeting for ectopic recoverin in SCLC is initially produced and cross-reacts with the retinal protein, resulting in the retinal degeneration that occurs in CAR patients.
|
8598320 |
1996 |
Cancer-Associated Retinopathy
|
0.050 |
Biomarker
|
disease |
BEFREE |
The mapping of recoverin to this region of human chromosome 17, which contains a number of cancer-related loci, suggests a possible mechanism by which cancer-associated retinopathy occurs in humans.
|
7745609 |
1995 |
Carney Complex
|
0.040 |
Biomarker
|
disease |
BEFREE |
The present data may correlate with the previous observation that recoverin-expressing cancer cells induced tumor immunity and a favorable prognosis for primary cancer in CAR patients.
|
19887879 |
2010 |
Carney Complex
|
0.040 |
Biomarker
|
disease |
BEFREE |
The present study demonstrates that human recoverin is expressed in SCLC cells cultured from an anti-recoverin antibody-negative patient with CAR.
|
17374419 |
2007 |
Carney Complex
|
0.040 |
Biomarker
|
disease |
BEFREE |
The CAR autoantigen has been identified as recoverin, a calcium-binding protein of the EF-hand superfamily.
|
15336963 |
2004 |
Carney Complex
|
0.040 |
Biomarker
|
disease |
BEFREE |
Nucleotide sequence analysis suggests that the CAR antigen shows approximately 90% homology to the published amino acid sequence of bovine recoverin.
|
1388144 |
1992 |
Malignant Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Recoverin is the first retina-specific photoreceptor protein that was shown to undergo aberrant expression, due to its promoter demethylation, as a cancer-retina antigen in a number of malignant tumors.
|
26813565 |
2016 |
Malignant Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Recoverin aberrantly expressed in lung and melanoma tumors can trigger the host immune response followed by the development of a paraneoplastic neurological syndrome represented by cancer- and melanoma-associated retinopathy, respectively.
|
20812967 |
2010 |
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Cytotoxic effects by anti-cancer drugs were higher in recoverin-positive A549 cells as compared to recoverin-negative cells.
|
19887879 |
2010 |
melanoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Recoverin aberrantly expressed in lung and melanoma tumors can trigger the host immune response followed by the development of a paraneoplastic neurological syndrome represented by cancer- and melanoma-associated retinopathy, respectively.
|
20812967 |
2010 |
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
The present data may correlate with the previous observation that recoverin-expressing cancer cells induced tumor immunity and a favorable prognosis for primary cancer in CAR patients.
|
19887879 |
2010 |
Primary malignant neoplasm
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Recoverin aberrantly expressed in lung and melanoma tumors can trigger the host immune response followed by the development of a paraneoplastic neurological syndrome represented by cancer- and melanoma-associated retinopathy, respectively.
|
20812967 |
2010 |
melanoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Visual rhodopsin, transducin, cGMP-phosphodiesterase 6, cGMP-dependent channels, guanylyl cyclase, rhodopsin kinase, recoverin and arrestin are expressed in melanoma and can induce antibody responses in patients.
|
17187367 |
2007 |
Small cell carcinoma of lung
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Establishment of a novel small cell lung carcinoma cell line with specific recoverin expression from a patient with cancer-associated retinopathy.
|
17374419 |
2007 |
Retinoblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The goal of this study was to determine if recoverin mRNA and protein are expressed in cultured human Y79 retinoblastoma cells, so that this cell line could be used as a model to study the mechanism of recoverin gene expression in the retina.
|
8666979 |
1996 |
Small cell carcinoma of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our results support the hypothesis that, in cancer-associated retinopathy (CAR) patients, auto-immune antibody targeting for ectopic recoverin in SCLC is initially produced and cross-reacts with the retinal protein, resulting in the retinal degeneration that occurs in CAR patients.
|
8598320 |
1996 |
Retinoblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Direct sequencing of a Y79 retinoblastoma cDNA polymerase chain reaction (PCR) product confirmed the presence of recoverin in this human cell line.
|
8500558 |
1993 |
Autoimmune retinopathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
This model supports the hypothesis that recoverin-specific T cell responses are major drivers of AIR pathogenesis and that IL-10 is an important factor in protection.
|
30635390 |
2019 |
Renal Cell Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this work, we demonstrated that recoverin is indeed expressed in 68.4 % of patients with different subtypes of renal cell carcinoma, and this expression has tendency to correlate with tumor size.
|
26813565 |
2016 |
Kidney Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, these data allow to consider recoverin as a potential therapeutic target and/or marker for renal tumors.
|
26813565 |
2016 |
Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
While the recoverin expression does not correlate withoverall survival of the tumor patients, the methylation of the recoverin gene promoter at -80 position is associated with better overall survival of the patients.
|
26813565 |
2016 |
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this work, we demonstrated that recoverin is indeed expressed in 68.4 % of patients with different subtypes of renal cell carcinoma, and this expression has tendency to correlate with tumor size.
|
26813565 |
2016 |