|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.670 |
GeneticVariation
|
disease |
GWASCAT |
Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease.
|
28869590 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.670 |
GeneticVariation
|
disease |
GWASDB |
Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci.
|
22325160 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.670 |
GeneticVariation
|
disease |
GWASCAT |
Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population.
|
30718926 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.670 |
GeneticVariation
|
disease |
BEFREE |
Fourth, a multiethnic meta-analysis of all 39 studies identified T2D-associated variants in BCL2 (p = 2.1 × 10(-8)).
|
22325160 |
2012 |
|
Alzheimer's Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that the Bcl-2 rs956572 polymorphism is associated with different strengths of structural covariance in AD that determine clinical outcomes.
|
29422088 |
2018 |
|
Malignant tumor of colon
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We report the case of a 53-year-old man who had a history of colon cancers related to constitutional hMLH1 mutation and who was diagnosed as having a duodenal follicular lymphoma This diagnosis was supported by IgH-BCL2 rearrangement and BCL2 immunoreactivity in tumor cells.
|
10824932 |
2000 |
|
Lymphoma, Follicular
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
By N-PCR, a total of 42 (51%) FL cases showed BCL-2 rearrangement: 28 (34%) for major breakpoint region (MBR) and 14 (17%) for minor cluster region (mcr).
|
14757440 |
2004 |
|
Lymphoma, Follicular
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
We present here a case of Follicular Lymphoma with leukemic presentation and a complex translocation involving the IgH, BCL2 and BCL6 loci.
|
16194898 |
2005 |
|
Lymphoma, Follicular
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Follicular lymphoma (FL) is an indolent, mature B-cell neoplasm classically characterised by the t(14;18)(q32;q21) with constitutive overexpression of the anti-apoptotic protein, BCL2.
|
31791624 |
2020 |
|
Lymphoma, Follicular
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These data show that bcl-2 translocation is present in 57% of follicular lymphomas in Chinese patients, and support the notion that bcl-2 translocation is a consistent marker for follicular lymphomas irrespective of ethnic differences.
|
2223650 |
1990 |
|
Lymphoma, Follicular
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
The low frequency of BCL-2/IgH translocation in healthy Chinese individuals of Han nationality located in Zhejiang area may be one of the reasons for the difference in the incidence of FL between China and Western countries.
|
16215945 |
2005 |
|
Lymphoma, Follicular
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In this patient's leukemic cells, the breakpoint of the t(14;18) translocation occurred in the major breakpoint-cluster region of the BCL2 gene and became linked to the JH4 joining-region gene segment of the immunoglobulin heavy-chain locus on the 14q+ chromosome as previously observed in follicular lymphoma.
|
3186743 |
1988 |
|
Lymphoma, Follicular
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Translocation t(14;18)(q32;q21) and/or BCL-2-IGH gene rearrangements were the genomic alterations most frequently observed: 50% of S-DLBCL and 30% of dn-DLBCL.
|
16519699 |
2006 |
|
Lymphoma, Follicular
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Polymerase chain reaction (PCR) protocols have been developed to detect the t(14;18) translocation, which juxtaposes the bcl-2 proto-oncogene to the Ig heavy-chain (IgH) gene in 85% of follicular lymphomas and monoclonal rearrangements of the IgH gene in B-cell NHL that lack bcl-2 rearrangements.
|
8111048 |
1994 |
|
Lymphoma, Follicular
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Incidence and clinical significance of bcl-2/IgH rearrangements in follicular lymphoma.
|
12691144 |
2003 |
|
Lymphoma, Follicular
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The t(14;18)(q32;q21) associated with follicular lymphoma juxtaposes a portion of BCL-2 (18q21) and IGH(14q32); the result is bcl-2 overexpression.
|
12953811 |
2003 |
|
Lymphoma, Follicular
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Detection and quantification of MBR/JH2 t(14;18) BCL-2 gene rearrangement in follicular lymphoma using a combined real-time polymerase chain reaction assay.
|
16704964 |
2006 |
|
Lymphoma, Follicular
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The rest comprises a small part of low-grade FL without Bcl2 gene translocation and high-grade (grade 3a, 3b) FL.
|
15815725 |
2005 |
|
Lymphoma, Follicular
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
FISH is better than BIOMED-2 PCR to detect IgH/BCL2 translocation in follicular lymphoma at diagnosis using paraffin-embedded tissue sections.
|
17964648 |
2008 |
|
Lymphoma, Follicular
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Follicular lymphoma is characterized by the presence of the t(14;18)(q32;q21) chromosomal translocation that juxtaposes the bcl-2 gene at 18q21 with the immunoglobulin heavy chain (IgH) locus at 14q32.
|
11950920 |
2002 |
|
Lymphoma, Follicular
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Molecular epidemiology of follicular lymphoma in Chinese: relationship with bcl-2/IgH translocation and bcl-6 397G/C polymorphism.
|
15875184 |
2005 |
|
Lymphoma, Follicular
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We present here a case of Follicular Lymphoma with leukemic presentation and a complex translocation involving the IgH, BCL2 and BCL6 loci.
|
16194898 |
2005 |
|
Lymphoma, Follicular
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The chromosomal translocation t(14;18)(q32;q21), which involves the bcl-2 oncogene, occurs in most follicular lymphomas.
|
8209865 |
1994 |
|
Lymphoma, Follicular
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Frequency of the Bcl-2/IgH rearrangement in normal individuals: implications for the monitoring of disease in patients with follicular lymphoma.
|
11208834 |
2001 |
|
Lymphoma, Follicular
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The t(14;18)/IGH-BCL2 chromosomal translocation occurred frequently in gastrointestinal follicular lymphomas.
|
24048795 |
2011 |