Diabetes Mellitus, Non-Insulin-Dependent
|
0.670 |
AlteredExpression
|
disease |
BEFREE |
Eight weeks after liraglutide or human umbilical cord mesenchymal stem cell administration, FPG, HbA<sub>1c</sub> , glucagon, body weight, and pancreatic ASK1, JNK, and BAX mRNA and proteins were significantly decreased, and the levels of serum C-p, INS and GLP-1, ratio of insulin positive area, and Bcl-2 expression were significantly increased in three treatment groups compared with T2DM group (P<.05).
|
31411368 |
2020 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.670 |
AlteredExpression
|
disease |
BEFREE |
In addition, nesfatin-1 treatment upregulated the PCNA and Bcl2 expression and inhibited the caspase-3 and prohibitin expression in T2DM mice.
|
31691259 |
2020 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.670 |
GeneticVariation
|
disease |
GWASCAT |
Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population.
|
30718926 |
2019 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.670 |
AlteredExpression
|
disease |
BEFREE |
Western blot, ELISA and qRT-PCR results showed that the mRNA and protein expression profiles of Caspase-3 and Bax were highly up-regulated and that Bcl-2 was down-regulated in the T2DM-PD-p38 inhibitor group.
|
30593206 |
2018 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.670 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, we found that the level of anti-apoptotic protein Bcl-2 was decreased (approximately 2-fold) with a concomitant increase in cleaved caspase-3 (approximately 3-fold) in T2D retina compared to control.
|
30453650 |
2018 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.670 |
AlteredExpression
|
disease |
BEFREE |
Additionally, cellular apoptosis in rats with DM was increased, and the expression of Bcl‑2 was downregulated, while levels of Bcl‑2‑associated X and caspase‑3 were upregulated, and these observations were reversed by MLT, as determined by TUNEL and western blot analysis, respectively.
|
29115422 |
2018 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.670 |
AlteredExpression
|
disease |
BEFREE |
Moreover, Ex-4 regulated several markers for autophagy in GK rat brains (as mTOR, PI3K class III, LC3 II, Atg7, p62, LAMP-1, and Parkin), ultimately protecting against apoptosis (by decreasing several caspase-like activities and mitochondrial cytochrome c, and increasing Bcl2 levels upon T2D).
|
28573460 |
2018 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.670 |
GeneticVariation
|
disease |
GWASCAT |
Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease.
|
28869590 |
2017 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.670 |
Biomarker
|
disease |
RGD |
The hyperglycemia stimulated myocardial endoplasmic reticulum (ER) stress contributes to diabetic cardiomyopathy in the transgenic non-obese type 2 diabetic rats: a differential role of unfolded protein response (UPR) signaling proteins.
|
23032698 |
2013 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.670 |
GeneticVariation
|
disease |
GWASDB |
Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci.
|
22325160 |
2012 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.670 |
GeneticVariation
|
disease |
BEFREE |
Fourth, a multiethnic meta-analysis of all 39 studies identified T2D-associated variants in BCL2 (p = 2.1 × 10(-8)).
|
22325160 |
2012 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.670 |
Biomarker
|
disease |
CTD_human |
Up-regulation of heme oxygenase provides vascular protection in an animal model of diabetes through its antioxidant and antiapoptotic effects.
|
16959961 |
2006 |