Lymphoma, Follicular
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Follicular lymphoma (FL) is an indolent, mature B-cell neoplasm classically characterised by the t(14;18)(q32;q21) with constitutive overexpression of the anti-apoptotic protein, BCL2.
|
31791624 |
2020 |
Lymphoma, Follicular
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
It is considered that BCL2 overexpression underscores the development of the majority of cases of FL and their transformation to more aggressive lymphoma [known as transformed FL (tFL)].
|
31789408 |
2020 |
Lymphoma, Follicular
|
0.600 |
Biomarker
|
disease |
BEFREE |
Since 2000, we have investigated 67 consecutive patients with stage I/II follicular lymphoma (FL) for the presence of BCL2/IGH rearrangements by polymerase chain reaction (PCR), real time quantitative PCR (RQ-PCR) and digital droplet PCR (ddPCR).
|
31385309 |
2020 |
Lymphoma, Follicular
|
0.600 |
Biomarker
|
disease |
BEFREE |
Arguably the MYC activity gain is the most constantly observed phenomenon (>70% of cases) in transformed FL/MALT/CLL (Richter's transformation) and co-occurs with specific aberrations such as the loss of p53, CDKN2A/B, or gain of BCL2/BCL6.
|
31631728 |
2020 |
Lymphoma, Follicular
|
0.600 |
Biomarker
|
disease |
BEFREE |
Validating the association with HGBL-DH/TH- BCL2, 11 of 25 DHITsig-positive-transformed follicular lymphomas were classified as HGBL-DH/TH- BCL2 compared with zero of 50 in the DHITsig-negative group.
|
30523716 |
2019 |
Lymphoma, Follicular
|
0.600 |
Biomarker
|
disease |
BEFREE |
Unraveling Tumor Heterogeneity in an Apparently Monolithic Disease: BCL2 and Other Players in the Genetic Landscape of Nodal Follicular Lymphoma.
|
30931307 |
2019 |
Lymphoma, Follicular
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This paper describes how we discovered the juxtaposition of the MYC gene to the human immunoglobulin loci and how that finding was extended to characterize molecularly the t(14;18) chromosome translocation of follicular lymphoma and to clone the BCL2 gene.
|
28653191 |
2019 |
Lymphoma, Follicular
|
0.600 |
Biomarker
|
disease |
BEFREE |
These include B-lymphocyte proliferation and sustained clonal expansion by HCV-envelope protein stimulation of B-cell receptors, and prolonged HCV-infected B-cell growth by overexpression of an anti-apoptotic BCL-2 oncogene caused by the increased frequency of t(14;18) chromosomal translocations in follicular lymphomas.
|
31092372 |
2019 |
Lymphoma, Follicular
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Thus, either DLBCL or FL can give rise to aggressive double-hit lymphomas (DHL) with concurrent activation of MYC and BCL2.
|
30874346 |
2019 |
Lymphoma, Follicular
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Follicular lymphoma (FL) is the most common indolent B-cell non-Hodgkin lymphoma (NHL) with genetic alterations of BCL-2, KMT2B, and KMT6.
|
30693983 |
2019 |
Lymphoma, Follicular
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We showed that DLBCL with MYC/BCL2-DH, and those with BCL2 translocation, harbour the characteristic mutation signatures that are associated with follicular lymphoma and its high-grade transformation.
|
31844144 |
2019 |
Lymphoma, Follicular
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Moreover, we tested its ability to discriminate follicular lymphomas by the tumour grade and the BCL2 protein expression.
|
30609603 |
2019 |
Lymphoma, Follicular
|
0.600 |
Biomarker
|
disease |
BEFREE |
Molecular cytogenetics showed IGH/BCL2 fusion in the follicular lymphoma and amplification of IGH gene or trisomy/tetrasomy 14 in the PTCL.
|
29217426 |
2018 |
Lymphoma, Follicular
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Follicular lymphoma (FL) is the most frequent indolent lymphoma in the Western world and is characterized in almost all cases by the t(14;18) translocation that results in overexpression of BCL2, an anti-apoptotic protein.
|
29974035 |
2018 |
Lymphoma, Follicular
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We analyzed the presence of the t(14;18)(q32;q21) as a surrogate marker of the malignant clone in cells of the FL microenvironment using combined fluorescence immunophenotyping and interphase cytogenetics targeting the BCL2 gene locus.
|
29720207 |
2018 |
Lymphoma, Follicular
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
These results suggest a diverse portfolio of genetic alterations that may induce or regulate BCL2 expression or promote pathogenesis of t(14;18)-negative FL as well as a less specific but increased crosstalk with the microenvironment that may compensate for the lack of N-glycosylation.
|
28824170 |
2018 |
Lymphoma, Follicular
|
0.600 |
Biomarker
|
disease |
BEFREE |
The development of follicular lymphoma (FL) from a founder B cell with an upregulation of B-cell lymphoma 2 (BCL2), via the t(14;18) translocation, to a proliferating clone, poised to undergo further transformation to an aggressive lymphoma, illustrates the opportunistic Darwinian process of tumorigenesis.
|
29666116 |
2018 |
Lymphoma, Follicular
|
0.600 |
Biomarker
|
disease |
BEFREE |
New concepts in follicular lymphoma biology: From BCL2 to epigenetic regulators and non-coding RNAs.
|
30360879 |
2018 |
Lymphoma, Follicular
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Histopathological examination revealed FL of grade 1-2 with a follicular pattern and with strong expression of germinal center markers and B-cell lymphoma 2 (BCL2).
|
29963140 |
2018 |
Lymphoma, Follicular
|
0.600 |
Biomarker
|
disease |
BEFREE |
FISH analysis confirmed the presence of IgH/BCL2 rearrangement in both the low grade follicular lymphoma (FL) and transformed Langerhans cells sarcoma (LCS) samples, demonstrating a clonal relationship.
|
30322385 |
2018 |
Lymphoma, Follicular
|
0.600 |
Biomarker
|
disease |
BEFREE |
B-cell lymphoma 2 (BCL-2) was discovered at the breakpoint of the t(14;18) in follicular lymphoma >30 years ago.
|
30037885 |
2018 |
Lymphoma, Follicular
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The most common scenario is transformation of follicular lymphoma to either diffuse large B-cell lymphoma or high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 translocations; however, other indolent subtypes such as marginal zone lymphoma, lymphoplasmacytic lymphoma, small lymphocytic lymphoma/chronic lymphocytic leukemia, or even nodular lymphocyte predominant Hodgkin lymphoma, can undergo similar histologic transformation.
|
30213394 |
2018 |
Lymphoma, Follicular
|
0.600 |
Biomarker
|
disease |
BEFREE |
We retrospectively analyzed 133 patients (with previously untreated FL and a baseline PET) from 2 cohorts with either a baseline plasma sample (n = 61) or a bcl2-JH-informative peripheral blood (PB) sample (n = 68).
|
29636326 |
2018 |
Lymphoma, Follicular
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A leukemic double-hit follicular lymphoma associated with a complex variant translocation, t(8;14;18)(q24;q32;q21), involving BCL2, MYC, and IGH.
|
29310838 |
2018 |
Lymphoma, Follicular
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Double-hit follicular lymphomas seemed to be a different disease from high-grade B-cell lymphomas with MYC and BCL2 and/or BCL6 rearrangements and have an indolent clinical behavior similar to follicular lymphomas without MYC rearrangement.
|
28984304 |
2018 |