Colitis
|
0.550 |
Biomarker
|
disease |
BEFREE |
The aims of this study are to enhance bioavailability and investigate their impact on nuclear p65 and HIF-1α for the first time in experimental colitis.Dextran sulphate sodium was used to induce colitis in mice and effect of either free CAPE/PIC or CAPE/PIC loaded albumin nanoparticles treatment was observed on disease development and levels of cellular p65 and HIF-1α.Our results indicate that albumin nano-encapsulation of CAPE/PIC not only enhances its anti-inflammatory potential but also potentiates its ability to effectively modulate inflammation related biomolecular pathways.
|
30430451 |
2019 |
Colitis
|
0.550 |
Biomarker
|
disease |
BEFREE |
In conclusion, the present study demonstrated that EEN attenuated DSS‑ and TNBS‑induced colitis by inhibiting p65 activation via regulating the p38/MSK1 pathway, thus suggesting that EEN is effective in the treatment of colitis.
|
29901086 |
2018 |
Colitis
|
0.550 |
AlteredExpression
|
disease |
BEFREE |
Using a SOCS2<sup>-/-</sup> mice model of colitis we show that SOCS2-deficiency is pro-inflammatory and negatively correlates with NDR1 and nuclear p65 levels.
|
28216640 |
2017 |
Colitis
|
0.550 |
AlteredExpression
|
disease |
BEFREE |
The chitosan/pUNO-SIGIRR nanoparticles attenuated colonic tissue inflammation through the inhibition of TLR4/NF-κB overactivation by downregulating TLR4, MyD88 and NF-κB p65 expression in a mouse model of colitis.
|
28153604 |
2017 |
Colitis
|
0.550 |
Biomarker
|
disease |
CTD_human |
The role of cholinergic anti-inflammatory pathway in acetic acid-induced colonic inflammation in the rat.
|
23810507 |
2013 |
Colitis
|
0.550 |
Biomarker
|
disease |
RGD |
Effects of glutamine on proinflammatory gene expression and activation of nuclear factor kappa B and signal transducers and activators of transcription in TNBS-induced colitis.
|
18623154 |
2008 |
Colitis
|
0.550 |
Biomarker
|
disease |
BEFREE |
Local administration of p65 antisense phosphorothioate oligonucleotides abrogated clinical and histological signs of colitis and was more effective in treating TNBS-induced colitis than single or daily administration of glucocorticoids.
|
8782457 |
1996 |
Hypertensive disease
|
0.510 |
Biomarker
|
group |
BEFREE |
In the untreated hypertensive group, increased levels (<i>P</i><0.05) of the proinflammatory molecules p65 NF-κB, vascular cell adhesion molecule 1 and interleukin-6 antibody in the myocardium, aortic wall and PBMC were observed and were reduced with fasudil (<i>P</i><0.05).In conclusion, in this hypertension model, Rho-kinase and its pathway activation determined in circulating leukocytes reflect the activation of this pathway in the myocardium and in the aortic wall and are significantly related to myocardial remodeling (hypertrophy, fibrosis and inflammation).
|
30065083 |
2018 |
Hypertensive disease
|
0.510 |
Biomarker
|
group |
CTD_human |
Chronic infusion of epigallocatechin-3-O-gallate into the hypothalamic paraventricular nucleus attenuates hypertension and sympathoexcitation by restoring neurotransmitters and cytokines.
|
27659729 |
2016 |
Kidney Failure, Chronic
|
0.510 |
AlteredExpression
|
disease |
BEFREE |
Phosphorylated NF-κB p65 was expressed and colocalized with p53, p21, β-galactosidase, TGF-β1, and α-SMA in the kidneys of chronic renal failure (CRF) rats.
|
21832251 |
2011 |
Hypertensive disease
|
0.510 |
Biomarker
|
group |
CTD_human |
Benazepril, an angiotensin-converting enzyme inhibitor, alleviates renal injury in spontaneously hypertensive rats by inhibiting advanced glycation end-product-mediated pathways.
|
19018797 |
2009 |
Kidney Failure, Chronic
|
0.510 |
Biomarker
|
disease |
CTD_human |
Niacin ameliorates oxidative stress, inflammation, proteinuria, and hypertension in rats with chronic renal failure.
|
19420110 |
2009 |
Kidney Failure, Chronic
|
0.510 |
Biomarker
|
disease |
RGD |
Melatonin ameliorates oxidative stress, inflammation, proteinuria, and progression of renal damage in rats with renal mass reduction.
|
18077597 |
2008 |
Hypertensive disease
|
0.510 |
Biomarker
|
group |
RGD |
Renal NF-kappaB activation and TNF-alpha upregulation correlate with salt-sensitive hypertension in Dahl salt-sensitive rats.
|
16840655 |
2006 |
Ependymoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The present finding indicates that the TP53 p.R337H germline mutation is uncommon in patients with EPN in Brazil and screening of pediatric patients RELA fusion EPN may be informative to better understand the role of TP53 germline mutations in the development and prognosis of these tumors.
|
31728854 |
2020 |
Ependymoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Although most CEs in our group were immunopositive for L1CAM and showed C11orf95-RELA fusion, which have been associated with a poor prognosis in supratentorial ependymomas, all our patients had good outcomes.
|
31150846 |
2019 |
Ependymoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
We describe a novel RELA-fusion composed by a chimeric transcript C11orf95-LOC-RELA in a supratentorial WHO grade II EPN occurring in a 4-year-old child.
|
30631904 |
2019 |
Ependymoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Molecular characteristics are also important for the diagnosis of several other CNS tumors, such as RELA fusion-positive subtype of ependymoma, atypical teratoid rhabdoid tumor (AT/RT), embryonal tumor with multilayered rosettes, and solitary fibrous tumor/hemangiopericytoma.
|
31124566 |
2019 |
Ependymoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Here, we have used interphase fluorescent in situ hybridization (FISH) for C11orf95 and RELA, immunohistochemistry (IHC) for p65-RelA and the recently developed DNA methylation-based classification besides conventional histopathology, and compared the precision of the methods in 40 supratentorial pediatric brain tumors diagnosed as ependymomas in the past years.
|
30325077 |
2019 |
Ependymoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
By DNA methylation profiling, tumors with MN1 or RELA rearrangement clustered with high-grade neuroepithelial tumor with MN1 alteration (HGNET-MN1) and RELA-fusion ependymoma, respectively.
|
30876455 |
2019 |
Ependymoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
We used real-time polymerase chain reaction, conventional real-time polymerase chain reaction, and Sanger sequencing to characterize RELA fusion status in formalin-fixed paraffin-embedded samples from 42 ST-EPs (12 adults and 30 pediatric).
|
29266023 |
2019 |
Ependymoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Interestingly, almost half of the patients with RELA fusion-positive ependymomas are adults (13/28), and 89.3% (25/28) cases are anaplastic ependymomas, which suggests that RELA fusion testing is necessary in adults with STEEs.
|
31393268 |
2019 |
Ependymoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Increased CTL densities and upregulation of PD-L1 in ST-RELA ependymomas suggests potential candidature for immunotherapy.
|
31388782 |
2019 |
Ependymoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Furthermore, treatment of the RELA-fused EPN cell line with the Notch inhibitors impaired the Notch signaling expression and revealed that Notch axis is not essential for cell proliferation and survival in this setting.
|
31308481 |
2019 |
Ependymoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A De Novo Mouse Model of C11orf95-RELA Fusion-Driven Ependymoma Identifies Driver Functions in Addition to NF-κB.
|
29949764 |
2018 |