|
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In the present study, we examined effects of renin-angiotensin system (RAS) on cardiac hypertrophy and renal disorders using Tsukuba hypertensive mice.
|
9607405 |
1998 |
|
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Thus, our data, in this large and ethnically homogeneous group of patients, do not support the hypothesis that these genetic variants of the renin-angiotensin system are strongly associated with either nephropathy or hypertension in patients with insulin-dependent or non-insulin-dependent diabetes mellitus.
|
9049480 |
1997 |
|
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
These include: (1) the intra-renal renin-angiotensin system (RAS), one based on molecular variations in angiotensinogen; (2) the Na, K, 2Cl cotransporter (NKCC2) and its regulators in the thick ascending limb, which are associated with a variety of phenotypes consistent with a more active cotransporter in blacks; and (3) the genes for MYH9 and APOL 1, which have been associated with kidney disease in blacks.
|
23397215 |
2013 |
|
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We speculate that presymptomatic patients with normal renal function who have genetic or familial FSGS may benefit from early blockade of the renin-angiotensin axis and that this may also prevent progressive renal disease.
|
17530296 |
2007 |
|
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Angiotensin II, the most vasoactive component of the renin-angiotensin-aldosterone (RAAS) pathway, can contribute to renal disease by causing an increase in arterial blood pressure leading to glomerular injury and fibrosis.
|
18206321 |
2008 |
|
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
A novel REN gene mutation resulted in an alteration in the amino acid sequence of the renin signal sequence and caused childhood anemia, polyuria, and kidney disease.
|
21084044 |
2010 |
|
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Genetics of the renin-angiotensin system and renal disease: a progress report.
|
9146976 |
1997 |
|
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Significance of genetic polymorphisms of the renin-angiotensin-aldosterone system in cardiovascular and renal disease.
|
19290794 |
2009 |
|
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Finally, half of the patients in all three age groups with heart failure and kidney disease received treatment with renin-angiotensin-system inhibitors; about two out of five patients received beta-blockers, while prescription rates of aldosterone inhibitors were low.
|
30187290 |
2018 |
|
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Genetic variants of the renin-angiotensin system (RAS) have been implicated in the progression of native kidney diseases.
|
11923700 |
2002 |
|
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We examined an association of the three renin-angiotensin system (RAS) gene polymorphisms with renal disease and progression to ESRD in dialyzed patients.
|
16384824 |
2006 |
|
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The involvement of renin-angiotensin system (RAS) gene polymorphisms in the pathogenesis of nephropathy has been described predominantly in Caucasian populations.
|
11200871 |
2001 |
|
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Genetic associations between genes in the renin-angiotensin-aldosterone system and renal disease: a systematic review and meta-analysis.
|
31048445 |
2019 |
|
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
As the intrarenal renin-angiotensin system might also be activated in this setting, we determined the ACE genotype together with other risk factors for the development of diabetic nephropathy in 122 patients with IDDM from a single centre with (n = 63) and without (n = 59) nephropathy.
|
9084972 |
1997 |
|
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Angiotensin II and aldosterone are the main effectors of the renin-angiotensin aldosterone system (RAAS) and have a central role in hypertension as well as cardiovascular and renal disease.
|
31425690 |
2019 |
|
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The role of the renin-angiotensin-aldosterone system in the pathophysiology of hypertension, and cardiovascular and kidney diseases is well known and the renin-angiotensin-aldosterone system is a major regulator of blood pressure through its effect on body fluids and electrolyte homeostasis.
|
31472818 |
2019 |
|
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Relationship between polymorphisms in the renin-angiotensin system and nephropathy in type 2 diabetic patients.
|
11938025 |
2002 |
|
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The influence of renin-angiotensin system genotypes on the antiproteinuric response to high doses of olmesartan in non-diabetic proteinuric nephropathies.
|
24241364 |
2013 |
|
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
As angiotensin II increases glomerular pressure, we studied the relationship between genetic polymorphisms in the renin-angiotensin system-angiotensin I converting enzyme (ACE), angiotensinogen (AGT), and angiotensin II, subtype 1, receptor-and the renal involvement of insulin-dependent diabetic subjects with proliferative retinopathy: those exposed to the risk of nephropathy due to diabetes.
|
9120002 |
1997 |
|
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Most of the patients with cognitive decline suffer of various metabolic imbalances, hypertension, cardiac and kidney disease, many of them which are treated with oral administration of Renin-angiotensin aldosterone system-altering agents like those presented above.
|
31106575 |
2019 |
|
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Role of genetic variability in the renin-angiotensin system in diabetic and nondiabetic renal disease.
|
11709806 |
2001 |
|
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We determined various cardiovascular hormones of the renin-angiotensin system and angiotensin converting enzyme gene polymorphism in 56 patients with nondiabetic renal diseases who underwent a renal biopsy.
|
10100072 |
1999 |
|
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Despite optimal therapy of diabetic nephropathy with agents blocking the renin-angiotensin-aldosterone system, the residual risk of nephropathy progression to end-stage renal disease (ESRD) remains high.
|
28520568 |
2017 |
|
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We report a novel dominant REN mutation discovered in an individual after forty years of renal disease.
|
28701203 |
2017 |
|
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Examination of two genetic polymorphisms within the renin-angiotensin system: no evidence for an association with nephropathy in IDDM.
|
8877296 |
1996 |