|
Left Ventricular Hypertrophy
|
0.600 |
Biomarker
|
disease |
CTD_human |
Systolic blood pressure, plasma renin activity, and cardiac angiotensin converting enzyme activity of L-NAME rats with left ventricular hypertrophy were significantly higher than those of the subgroup without.(ABSTRACT TRUNCATED AT 250 WORDS)
|
8349331 |
1993 |
|
Left Ventricular Hypertrophy
|
0.600 |
Biomarker
|
disease |
BEFREE |
The cardiac renin-angiotensin system has been suggested to be involved in the development of left ventricular hypertrophy.
|
7994801 |
1994 |
|
Left Ventricular Hypertrophy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We conclude that, in this population, variations in the renin or ACE genes do not contribute significantly to the development of LVH or to essential hypertension.
|
8076423 |
1994 |
|
Left Ventricular Hypertrophy
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Enalapril-induced regression of left ventricular hypertrophy and improvement in left ventricular impaired diastolic filling were significantly greater in the DD genotype group than they were in the ID and II genotype groups, suggesting that the circulating and tissue renin-angiotensin systems, particularly the former system, are most active in hypertensive patients with the DD genotype.
|
8986921 |
1996 |
|
Left Ventricular Hypertrophy
|
0.600 |
Biomarker
|
disease |
BEFREE |
In patients with aortic stenosis, genetic variants of proteins from the renin angiotensin system may be at least as important as left ventricular systolic pressure in determining the degree of left ventricular hypertrophy and could therefore explain the clinical variation observed in the progression to cardiac dysfunction.
|
8800593 |
1996 |
|
Left Ventricular Hypertrophy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Renin-angiotensin system gene polymorphisms and left ventricular hypertrophy. The case against an association.
|
9433518 |
1997 |
|
Left Ventricular Hypertrophy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
To examine the contribution of the renin-angiotensin system to hypertrophic cardiomyopathy (HCM), we studied 96 patients with HCM (mean age 50 years, 55% male), 105 of their unaffected siblings and offspring, and 160 healthy subjects without known hypertension and left ventricular hypertrophy (LVH) who were frequency matched to cases by age and sex.
|
9023164 |
1997 |
|
Left Ventricular Hypertrophy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We investigated whether the angiotensin II type 1 receptor (AT1-R) A/C1166 polymorphism, the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism, and/or plasma renin influence LVH in HCM.
|
9822439 |
1998 |
|
Left Ventricular Hypertrophy
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Subsequent treatment with cilazapril significantly improved LV morphology and function in those with residual LV hypertrophy or elevated plasma renin activity.
|
10937840 |
2000 |
|
Left Ventricular Hypertrophy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Untreated transgenic rats overexpressing the human renin and angiotensinogen genes (dTGR) feature hypertension and severe left ventricular hypertrophy with focal areas of necrosis, and die at age 7 weeks.
|
10880382 |
2000 |
|
Left Ventricular Hypertrophy
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In hypertension the 825T allele is associated with low renin activity and appears to strongly predict the development of left ventricular hypertrophy.
|
10978382 |
2000 |
|
Left Ventricular Hypertrophy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Genetic polymorphisms of the renin-angiotensin-aldosterone system (RAAS) have been considered to trigger the response of the left ventricle to chronic pressure overload and determine the degree of LVH in patients with AS.
|
11275936 |
2001 |
|
Left Ventricular Hypertrophy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In the light of these observations it seems reasonable to make a preliminary conclusion about lack of association between LVH and distinct polymorphisms of renin-angiotensin system genes in the population studied.
|
11688760 |
2001 |
|
Left Ventricular Hypertrophy
|
0.600 |
Biomarker
|
disease |
BEFREE |
The renin angiotensin system modulates vascular structure and left ventricular hypertrophy via a number of trophic effects.
|
11177655 |
2001 |
|
Left Ventricular Hypertrophy
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
TGR rats showed left ventricular hypertrophy (54%), higher blood pressures (76 mmHg), and elevated plasma renin activity (seven-fold) compared to controls (P < 0.01).
|
11518854 |
2001 |
|
Left Ventricular Hypertrophy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Left ventricular hypertrophy in patients with hypertension is a main clinical prognostic entity The aim of this study was to evaluate the association between mutations at genes of the renin-angiotensin system (RAS) and the development of left ventricular hypertrophy.
|
12425365 |
2002 |
|
Left Ventricular Hypertrophy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
To determine the influence of genetic polymorphisms of the renin-angiotensin-aldosterone system (RAAS) on ECG and two dimensional echocardiographic left ventricular hypertrophy (LVH) in genetically identical patients with HCM.
|
11847170 |
2002 |
|
Left Ventricular Hypertrophy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These data suggest that genetic considerations may contribute importantly to risk stratification, and perhaps therapeutic interventions targeted at LVH and the renin-angiotensin system in hypertensive patients.
|
12195118 |
2002 |
|
Left Ventricular Hypertrophy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our aim was to determine if gene polymorphisms in the renin-angiotensin-aldosterone system (RAAS) were related to the degree of change in left ventricular hypertrophy (LVH) during antihypertensive treatment.
|
11910301 |
2002 |
|
Left Ventricular Hypertrophy
|
0.600 |
Biomarker
|
disease |
BEFREE |
Angiotensinogen (AGT), the precursor of angiotensin II and a rate limiting factor in the renin-angiotensin system, is implicated in left ventricular hypertrophy, as angiotensin II is a potent stimulator of cardiac growth.
|
16280278 |
2005 |
|
Left Ventricular Hypertrophy
|
0.600 |
Biomarker
|
disease |
BEFREE |
Existing data show that the renin-angiotensin-aldosterone (RAA) system may play a role in the development of LVH.
|
17054027 |
2006 |
|
Left Ventricular Hypertrophy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The association of renin-angiotensin system (RAS) polymorphisms and left-ventricular hypertrophy (LVH) may depend on the presence of risk factors for LVH, such as renal dysfunction.
|
17903694 |
2007 |
|
Left Ventricular Hypertrophy
|
0.600 |
Biomarker
|
disease |
CTD_human |
A nonpeptide, piperidine renin inhibitor provides renal and cardiac protection in double-transgenic mice expressing human renin and angiotensinogen genes.
|
18679781 |
2008 |
|
Left Ventricular Hypertrophy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Myocardial fibrosis in patients with symptomatic obstructive hypertrophic cardiomyopathy: correlation with echocardiographic measurements, sarcomeric genotypes, and pro-left ventricular hypertrophy polymorphisms involving the renin-angiotensin-aldosterone system.
|
18835191 |
2009 |
|
Left Ventricular Hypertrophy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of the renin-angiotensin-aldosterone system (RAAS) represent an attractive hypothesis as potential disease modifiers, as these genetic variants alter the 'activation status' of the RAAS, which leads to more left ventricular hypertrophy through different pathways.
|
21507890 |
2011 |