REN, renin, 5972

N. diseases: 721; N. variants: 25
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.370 GeneticVariation disease BEFREE Transgenic mice that express only the human renin gene were normotensive and yet exhibited a low bone mass, suggesting that osteoporosis occurs independently of the development of hypertension per se. 18847324 2009
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.370 Biomarker disease BEFREE Effects of 1,25-dihydroxyvitamin D<sub>3</sub> on the local bone renin-angiotensin system in a murine model of glucocorticoid-induced osteoporosis. 28587403 2017
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.370 Biomarker disease BEFREE The skeletal renin-angiotensin system plays key role in the pathological process of osteoporosis. 26439241 2016
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.370 Biomarker disease BEFREE Tissue renin-angiotensin-aldosterone system (RAAS) activation in sites of osteoporosis had been demonstrated in animal studies; however, the possibility of RAAS blockade to prevent future osteoporotic fracture had rarely been verified in clinical studies. 29145244 2017
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.370 Biomarker disease BEFREE The renin-angiotensin aldosterone system and osteoporosis: findings from the Women's Health Initiative. 31209511 2019
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.370 GeneticVariation disease BEFREE By contrast, people living in a nursing home were less commonly prescribed statins (RR = 0.2), nonsteroidal antiinflammatory drugs (NSAIDs) (RR = 0.3), osteoporosis drugs (RR = 0.3), thiazide diuretics (RR = 0.4), calcium channel blockers (RR = 0.5) or renin-angiotensin inhibitors (RR = 0.5). 30782115 2019
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.370 AlteredExpression disease BEFREE Tetrahydroxy stilbene glucoside (TSG), an active component from medicinal herb Polygonum multiflorum Thunb, could block the activity of the tissue renin-angiotensin system (RAS), which plays a critical role in development of diabetic osteoporosis. 30456807 2019
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.370 Biomarker disease CTD_human Transgenic mice that express only the human renin gene were normotensive and yet exhibited a low bone mass, suggesting that osteoporosis occurs independently of the development of hypertension per se. 18847324 2009