Diabetes Mellitus, Non-Insulin-Dependent
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
In the patients with type 2 diabetes, age, gene dose of the I allele, and systolic and diastolic blood pressure were independently associated with increased a-PWV (R2 = 0.545, P < 0.0001), and age, gene dose of the I allele, and systolic blood pressure were associated with increases in carotid stiffness beta (R2 = 0.314, P < 0.0001).
|
10546020 |
1999 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
Our result suggests that Ser82 allele in the receptor for AGE gene is a low-risk allele for developing DR in Asian Indian patients who have type II diabetes.
|
12477623 |
2003 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
The specific aims were to: (1) evaluate the impact of genetic (single nucleotide polymorphisms [SNPs]), epigenetic (DNA methylation) and non-genetic (age) factors on the expression of COX7A1 in human skeletal muscle; and (2) investigate whether common variants in the COX7A1 gene are associated with increased risk of type 2 diabetes.
|
18488190 |
2008 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
Logistic regression analysis indicated that each unit reduction in the sRAGE concentration increased the MCI risk by 54% (OR 0.46[95% CI 0.22-0.96], p = 0.04) and that each unit increase in the AGE-P level increased the MCI risk by 72% in the type 2 diabetes patients (OR 1.72[95% CI 1.31-2.28], p<0.01).
|
26745632 |
2016 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
L-AGE ameliorates insulin resistance in obese people with the metabolic syndrome, and may reduce the risk of type 2 diabetes, without necessitating a major reduction in adiposity.
|
27468708 |
2016 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.090 |
Biomarker
|
disease |
BEFREE |
These findings establish that holo-RBP and its receptor STRA6 are potent regulators of diurnal insulin responses and suggest that the holo-RBP/STRA6 signaling axis may represent a novel therapeutic target in type II diabetes.
|
28733465 |
2017 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.090 |
Biomarker
|
disease |
BEFREE |
Earlier studies have shown that skin autofluorescence measured with an AGE reader estimates the accumulation of AGEs in the skin, which increases with ageing and is associated with the metabolic syndrome and type 2 diabetes.
|
30460578 |
2019 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.090 |
Biomarker
|
disease |
BEFREE |
Our study aims to investigate the effect of Irbesartan (the angiotensin II receptor antagonist) on the changes of AGE-RAGE system and MMP family components, and analyzes the potential mechanisms in type 2 diabetes-induced myocardial fibrosis.
|
31027433 |
2019 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.090 |
Biomarker
|
disease |
BEFREE |
LWDH Pill may play a role in the treatment of T2DM and its complications (atherosclerosis and nephropathy) through the AGE-RAGE signaling pathway, TNF signaling pathway, and NF-kappa B signaling pathway.
|
31819371 |
2019 |