Papillary thyroid carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Identification of the product of two oncogenic rearranged forms of the RET proto-oncogene in papillary thyroid carcinomas.
|
1437145 |
1992 |
Papillary thyroid carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Detection of RET oncogene activation in human papillary thyroid carcinomas by in situ hybridisation.
|
1457350 |
1992 |
Papillary thyroid carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
RET/PTC is a transforming sequence created by the fusion of the tyrosine kinase domain of the RET protooncogene with the 5' end of the locus D10S170 designated by probe H4 and is frequently found activated in human papillary thyroid carcinomas.
|
1542652 |
1992 |
Papillary thyroid carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our study suggests that the rearrangement of the ret proto-oncogene may be involved in the development of distant metastases in patients with papillary thyroid carcinomas.
|
1620547 |
1992 |
Papillary thyroid carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
A reverse transcriptase-polymerase chain reaction (RT-PCR) method was adopted for detecting transcripts specific for retTPC/PTC, an activated form of the ret proto-oncogene reported to be found specifically in human papillary thyroid carcinomas.
|
1717926 |
1991 |
Papillary thyroid carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
This rearrangement could affect the ret-proto-oncogene, localized to 10q11.2 which is activated in some papillary thyroid carcinomas.
|
1745982 |
1991 |
Papillary thyroid carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
These findings suggest that intrachromosomal rearrangements are responsible for PTC activation in papillary thyroid carcinomas.
|
2000227 |
1991 |
Papillary thyroid carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
The aberrant tyrosine kinase activity induced by the rearrangement of ret proto-oncogene could be involved in the development of papillary thyroid carcinoma.
|
2334411 |
1990 |
Papillary thyroid carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Presence of aberrant transcripts of ret proto-oncogene in a human papillary thyroid carcinoma cell line.
|
2516841 |
1989 |
Papillary thyroid carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Since both PTC, a novel rearranged form of RET, and TRK display a tyrosine protein kinase activity, it is proposed that the activation of this class of oncogenes is specifically involved in the pathogenesis of papillary thyroid cancer.
|
2594368 |
1989 |
Papillary thyroid carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Finally the orientation of RET on chromosome 10q11.2 made it possible to orientate three other genes rearranged with RET in papillary thyroid carcinomas, namely H4/D10S170 on 10q21, R1 alpha on 17q23 and RFG2/Ele1 on 10q11.2.
|
7478601 |
1995 |
Papillary thyroid carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Activation of the ret proto-oncogene by three different chromosomal rearrangements occurs in up to 25% of papillary thyroid carcinomas.
|
7491517 |
1995 |
Papillary thyroid carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A t(10;17) translocation creates the RET/PTC2 chimeric transforming sequence in papillary thyroid carcinoma.
|
7519046 |
1994 |
Papillary thyroid carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
This previously uncharacterized gene is fused with the tyrosine kinase (tk) domain of the RET proto-oncogene to generate the oncogenic sequence RET/PTC3, thus providing a third example of RET oncogenic activation in papillary thyroid carcinomas.
|
7529046 |
1994 |
Papillary thyroid carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Oncogenic rearrangements of the RET proto-oncogene in papillary thyroid carcinomas from children exposed to the Chernobyl nuclear accident.
|
7585643 |
1995 |
Papillary thyroid carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
PTC-1, the predominant form of PTC oncogene in human papillary thyroid carcinoma, encodes a fusion protein containing the N-terminus of H4 (D10S170) fused 5' to the ret tyrosine kinase domain.
|
7753554 |
1995 |
Papillary thyroid carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Tumor specific rearrangements of ret gene are frequently detected in papillary thyroid carcinomas.
|
8187085 |
1994 |
Papillary thyroid carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Genetic background among races may contribute to the different frequencies of PTC/retTPC oncogene in thyroid papillary carcinoma.
|
8275421 |
1994 |
Papillary thyroid carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Here we report the identification and cloning of a novel rearranged version of the RET oncogene in a human thyroid papillary carcinoma.
|
8290261 |
1994 |
Papillary thyroid carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Two-thirds of the papillary thyroid carcinomas of the children revealed a RET rearrangement, with ret/PTC3 being more frequent by a factor of 3 than ret/PTC1. ret/PTC2 was not detected.
|
8545102 |
1995 |
Papillary thyroid carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
RET is activated, as RET/PTC oncogene, by somatic rearrangements which link the TK domain to a constitutive dimerization interface in papillary thyroid carcinomas.
|
8570194 |
1995 |
Papillary thyroid carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
The RET proto-oncogene has been implicated in the causation of papillary thyroid carcinoma, multiple endocrine neoplasia types 2A (MEN 2A) and 2B (MEN 2B), and Hirschsprung's disease.
|
8579892 |
1995 |
Papillary thyroid carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
These two observations could be related to the reported increased incidence of papillary thyroid carcinomas in children living in contaminated areas around Chernobyl, given that it has been demonstrated that about 60% of them presents a RET oncogenic activation.
|
8626874 |
1996 |
Papillary thyroid carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Breakpoint characterization of the ret/PTC oncogene in human papillary thyroid carcinoma.
|
8634704 |
1995 |
Papillary thyroid carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Proto-RET is rearranged in the new human papillary thyroid cancer cell line PTC-1113A.
|
8689603 |
1996 |