Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Secondary malignant neoplasm of lymph node
0.100 AlteredExpression disease BEFREE Presence of RET/PTC rearrangement significantly correlated with gender, elevated TSH levels and lymph node metastasis. 30467698 2020
Secondary malignant neoplasm of lymph node
0.100 GeneticVariation disease BEFREE The univariate analysis showed that age (P = .008), gender (P = .016), smoking history (P = .010), lymph node metastasis (P = .003), and three driver genes, positive epidermal growth factor receptor (EGFR) mutation (P = .001), positive anaplastic lymphoma kinase (ALK) gene fusion (P = .021), and positive rearranged during transfection (RET) gene fusion (P = .003), were the factors influencing the incidence of brain metastasis. 31769228 2020
Secondary malignant neoplasm of lymph node
0.100 GeneticVariation disease BEFREE RET mutation was related to cervical lymph node metastasis in patients with MTC, especially the mutation in Exon 11&13. 31494787 2019
Secondary malignant neoplasm of lymph node
0.100 AlteredExpression disease BEFREE After analyzing the RNA-Seq data of PTC patients from the Cancer Genomic Atlas, 497 differentially expressed PTC genes were found to be associated with HT, of which protein tyrosine phosphatase receptor type C (PTPRC), KIT, and COL1A1 were associated with tumor size and lymph node metastasis (p < 0.05). 31686862 2019
Secondary malignant neoplasm of lymph node
0.100 GeneticVariation disease BEFREE The risk to develop lymph node metastases was eight times higher in presence of RET rearrangements (p = 0.010). 30472213 2019
Secondary malignant neoplasm of lymph node
0.100 GeneticVariation disease BEFREE There is good evidence that somatic RET mutations predict higher rates of lymph node metastasis and persistent disease, and worse survival. 31301229 2019
Secondary malignant neoplasm of lymph node
0.100 Biomarker disease BEFREE In addition, several clinicopathological factors such as age ≥45 years, VI, ETE, and LNM were shown to be significant risk factors for DM in both PTC and FTC subgroups. 28913696 2018
Secondary malignant neoplasm of lymph node
0.100 Biomarker disease BEFREE The multifocality rate of PTC was 35.1% and mPTC were shown to have larger primary tumor diameter, higher rate of lymph node metastasis and less number of accompanying non-cancerous lesions than single PTC in one or both gender groups. 28315434 2017
Secondary malignant neoplasm of lymph node
0.100 Biomarker disease BEFREE Comparing the cytological or, when performed, histological diagnoses with the results of FNAB-Tg, we found that in 24 cases of lymph node metastases from PTC (19 lymph nodes from patients at the first diagnoses and 5 lymph nodes from PTC patients in follow up) the mean level of Thyroglobulin was 1840.11 ng/ml; range: <0,2 to 11440 ng/ml. 28558632 2017
Secondary malignant neoplasm of lymph node
0.100 Biomarker disease BEFREE Decreased TDR was associated with capsular invasion, ETE and LNM in patients with multifocal PTMC and PTC. 28109462 2017
Secondary malignant neoplasm of lymph node
0.100 GeneticVariation disease BEFREE An activating M918T RET (c.2753T>C) somatic mutation was identified in a lymph node metastasis. 28068878 2017
Secondary malignant neoplasm of lymph node
0.100 Biomarker disease BEFREE ETE = extrathyroidal extension LNM = lymph node metastasis PTC = papillary thyroid carcinoma PTMC = papillary thyroid microcarcinoma RAI = radioactive iodine TNM = tumor, node, metastasis TTD = total tumor diameter. 28156153 2017
Secondary malignant neoplasm of lymph node
0.100 AlteredExpression disease BEFREE In addition, in PTMC patients with EI and/or LNM and/or positive BRAF (high-risk PTMC patients), the prevalence of extrathyroidal invasion, Hashimoto's disease, lymph node metastasis, tumor TNM stage, PEDF positive protein expression, the rate of recurrent disease, and the mRNA expression of anti-angiogenic factors was almost as high as in patients with larger PTC, but with no significant difference. 27936049 2016
Secondary malignant neoplasm of lymph node
0.100 GeneticVariation disease BEFREE One asymptomatic carrier had de novo codon 918 mutation (MEN2B) and showed bilateral microcarcinoma with lymph node metastasis at presentation and progressive disease on follow-up. 26033033 2015
Secondary malignant neoplasm of lymph node
0.100 AlteredExpression disease BEFREE Positive associations were found between levels of miR-146a expression in PTC tissues and gender (female), cervical lymph node metastasis, multifocality, extra tyroidal invasion and advanced clinical TNM stages (III and IV). 25524940 2015
Secondary malignant neoplasm of lymph node
0.100 GeneticVariation disease BEFREE Genome-wide copy number analysis in a family with p.G533C RET mutation and medullary thyroid carcinoma identified regions potentially associated with a higher predisposition to lymph node metastasis. 24601688 2014
Secondary malignant neoplasm of lymph node
0.100 GeneticVariation disease BEFREE In the present work, a comparative genomic hybridization (CGH) study was performed using DNA from a primary tumor in a M918T RET mutation-positive SMTC patient and from its lymph node metastasis to investigate additional genetic alterations. 22676344 2012
Secondary malignant neoplasm of lymph node
0.100 GeneticVariation disease BEFREE For each case, we sought RET somatic mutations in the primary cancer and in lymph node metastases. 21422198 2011
Secondary malignant neoplasm of lymph node
0.100 GeneticVariation disease BEFREE Several cytoskeletal protein species showed quantitative changes in tumors and lymph node metastases harboring RET/PTC1 or RET/PTC3. 20839015 2011
Secondary malignant neoplasm of lymph node
0.100 GeneticVariation disease BEFREE The closer mutations in codon 620, 618, and 611 were located to the transmembrane domain (codons 657-636) of the RET receptor, the greater were mean primary tumor diameters (23.5, 18.7, and 7.5 mm, P=0.020), the frequency of lymph node metastasis (75, 68, and 30%, P=0.11) and pheochromocytoma (38, 16, and 0%, P=0.11). 18936155 2009
Secondary malignant neoplasm of lymph node
0.100 GeneticVariation disease BEFREE More interestingly, the presence of a somatic RET mutation correlates with the presence of lymph node metastases at diagnosis, which is a known bad prognostic factor for the definitive cure of MTC patients. 18073307 2008
Secondary malignant neoplasm of lymph node
0.100 GeneticVariation disease BEFREE RET/PTC rearrangements presented at younger age and had predominantly typical papillary histology, frequent psammoma bodies, and a high rate of lymph node metastases. 16434896 2006
Secondary malignant neoplasm of lymph node
0.100 GeneticVariation disease BEFREE To our knowledge, this case represents the first documented case of concurrent lymph node metastases of MTC and PTC in a patient with RET proto-oncogene germline mutation. 14586073 2003
Secondary malignant neoplasm of lymph node
0.100 GeneticVariation disease BEFREE Tumors with ret/PTC gene rearrangements tended to have lymph node metastases rather than hematogenous spread. 10690905 2000
Secondary malignant neoplasm of lymph node
0.100 GeneticVariation disease BEFREE Identification of a novel subtype of H4-RET rearrangement in a thyroid papillary carcinoma and lymph node metastasis. 10675479 2000