|
THYROID CARCINOMA, SPORADIC MEDULLARY
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We investigated a case of an aggressive, apparently sporadic medullary thyroid carcinoma (MTC) harboring a somatic RET p.Cys634Arg mutation (a known MTC driver).
|
30321177 |
2018 |
|
THYROID CARCINOMA, SPORADIC MEDULLARY
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Clinical significance of RET and RAS mutations in sporadic medullary thyroid carcinoma: a meta-analysis.
|
29615431 |
2018 |
|
THYROID CARCINOMA, SPORADIC MEDULLARY
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
As there is a lack of somatic RET mutations reported previously for the Taiwanese population, we tried to assess the presence of somatic RET mutations and evaluate the potential outcome predictors for our sMTC patients.
|
27847096 |
2016 |
|
THYROID CARCINOMA, SPORADIC MEDULLARY
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Germline RET mutation carriers in Japanese patients with apparently sporadic medullary thyroid carcinoma: A single institution experience.
|
26837867 |
2016 |
|
THYROID CARCINOMA, SPORADIC MEDULLARY
|
0.200 |
Biomarker
|
disease |
BEFREE |
RAS mutations constitute a frequent molecular event in RET-negative sporadic medullary thyroid carcinoma in Polish patients.
|
25931041 |
2015 |
|
THYROID CARCINOMA, SPORADIC MEDULLARY
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Sporadic medullary thyroid carcinoma (MTC) harbors RET gene somatic mutations in up to 50 % of cases, and RAS family gene mutations occur in about 10 %.
|
24828033 |
2014 |
|
THYROID CARCINOMA, SPORADIC MEDULLARY
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Hereditary and sporadic medullary thyroid carcinoma (MTC) are closely associated with RET proto-oncogene mutations.
|
22038905 |
2012 |
|
THYROID CARCINOMA, SPORADIC MEDULLARY
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Chromosome 10 and RET gene copy number alterations in hereditary and sporadic Medullary Thyroid Carcinoma.
|
21867742 |
2012 |
|
THYROID CARCINOMA, SPORADIC MEDULLARY
|
0.200 |
Biomarker
|
disease |
BEFREE |
MicroRNA profiles in familial and sporadic medullary thyroid carcinoma: preliminary relationships with RET status and outcome.
|
22747440 |
2012 |
|
THYROID CARCINOMA, SPORADIC MEDULLARY
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The rare intracellular RET mutation p.Ser891Ala in an apparently sporadic medullary thyroid carcinoma: a case report and review of the literature.
|
23295303 |
2012 |
|
THYROID CARCINOMA, SPORADIC MEDULLARY
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Additive effect of RET polymorphisms on sporadic medullary thyroid carcinoma susceptibility and tumor aggressiveness.
|
22345297 |
2012 |
|
THYROID CARCINOMA, SPORADIC MEDULLARY
|
0.200 |
Biomarker
|
disease |
BEFREE |
Combined RET and Ki-67 assessment in sporadic medullary thyroid carcinoma: a useful tool for patient risk stratification.
|
21422198 |
2011 |
|
THYROID CARCINOMA, SPORADIC MEDULLARY
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The presence of the polymorphic change L769L in the RET gene predisposes to the development of sMTC and also lowers the age of onset of MTC in carriers of the homozygous polymorphic variant L769L.
|
20521125 |
2010 |
|
THYROID CARCINOMA, SPORADIC MEDULLARY
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The RET polymorphic allele S836S is associated with early metastatic disease in patients with hereditary or sporadic medullary thyroid carcinoma.
|
20801952 |
2010 |
|
THYROID CARCINOMA, SPORADIC MEDULLARY
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Activating mutations in the RET proto-oncogene are associated with both familial and sporadic medullary thyroid carcinoma (MTC) development; however, the genetic mechanisms underlying MTC tumorigenesis remain largely unknown.
|
18316595 |
2008 |
|
THYROID CARCINOMA, SPORADIC MEDULLARY
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Activating mutations in the RET protooncogene have been demonstrated in multiple endocrine neoplasia 2 and sporadic medullary thyroid carcinoma (MTC).
|
18765511 |
2008 |
|
THYROID CARCINOMA, SPORADIC MEDULLARY
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our data demonstrate that the RET G691S variant could modulate the age of onset of sMTC as demonstrated previously for familial tumours.
|
18331611 |
2008 |
|
THYROID CARCINOMA, SPORADIC MEDULLARY
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The frequency and prognostic relevance of RET proto-oncogene somatic mutations in sporadic medullary thyroid carcinoma (MTC) remain controversial.
|
18282654 |
2008 |
|
THYROID CARCINOMA, SPORADIC MEDULLARY
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
New multiple somatic mutations in the RET proto-oncogene associated with a sporadic medullary thyroid carcinoma.
|
16571096 |
2006 |
|
THYROID CARCINOMA, SPORADIC MEDULLARY
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Analysis of inherited genetic variants in ret proto-oncogene of Brazilian patients with apparently sporadic medullary thyroid carcinoma.
|
16487008 |
2006 |
|
THYROID CARCINOMA, SPORADIC MEDULLARY
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In addition, we tested as modifiers four other single nucleotide polymorphisms (SNPs), which we have found in a previous association study of RET, its coreceptors, and ligands to be associated with the risk of developing sporadic medullary thyroid carcinoma.
|
16424056 |
2006 |
|
THYROID CARCINOMA, SPORADIC MEDULLARY
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Occurrence of the Cys611Tyr mutation and a novel Arg886Trp substitution in the RET proto-oncogene in multiple endocrine neoplasia type 2 families and sporadic medullary thyroid carcinoma cases originating from the central region of Portugal.
|
16712668 |
2006 |
|
THYROID CARCINOMA, SPORADIC MEDULLARY
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our group had evidence about the existence of a low-penetrance susceptibility locus for sMTC in linkage disequilibrium with RET variants S836S/IVS1-126G>T, and probably in 5' with respect to both variants.
|
16646689 |
2006 |
|
THYROID CARCINOMA, SPORADIC MEDULLARY
|
0.200 |
Biomarker
|
disease |
BEFREE |
Polymorphisms in the initiators of RET (rearranged during transfection) signaling pathway and susceptibility to sporadic medullary thyroid carcinoma.
|
16091499 |
2005 |
|
THYROID CARCINOMA, SPORADIC MEDULLARY
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
RET polymorphisms and sporadic medullary thyroid carcinoma in a Portuguese population.
|
16230779 |
2005 |