|
Leukodystrophy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
It has recently been reported that abnormalities in aminoacyl t-RNA synthetase (ARS) genes are linked to various unique leukodystrophies and leukoencephalopathies.
|
30715177 |
2019 |
|
Pancytopenia
|
0.010 |
Biomarker
|
disease |
BEFREE |
<b>Conclusions:</b> The presentation of bone marrow failure and multiorogan injury associated with ARS in the New Zealand White rabbit model is consistent with that described in the canine, swine, non-human primate, and in humans.
|
31526203 |
2019 |
|
Aniridia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Cases of ARS with overlapping features with other ASD, like aniridia (complete or incomplete absence of iris), iridocorneal endothelial (ICE) syndrome (beaten metal appearance of corneal endothelium), Peters anomaly, isolated trabeculodysgenesis (evidenced by Haab's striae, buphthalmos, and epiphora) in one or both eyes with other typical ARS features in the same or other eye were included and screened.
|
27929720 |
2018 |
|
Malaria, Falciparum
|
0.010 |
Biomarker
|
disease |
BEFREE |
The pharmacokinetics (PK) and ex vivo activity (pharmacodynamics [PD]) of two artemisinin combination therapies (ACTs) (artemisinin-piperaquine [ARN-PPQ] [Artequick<sup>®</sup>] and artesunate-amodiaquine [ARS-AQ] [Coarsucam<sup>™</sup>]) in healthy Vietnamese volunteers were compared following 3-day courses of the ACTs for the preselection of the drugs for falciparum malaria therapy.
|
29741150 |
2018 |
|
Excessive tearing
|
0.010 |
Biomarker
|
disease |
BEFREE |
Cases of ARS with overlapping features with other ASD, like aniridia (complete or incomplete absence of iris), iridocorneal endothelial (ICE) syndrome (beaten metal appearance of corneal endothelium), Peters anomaly, isolated trabeculodysgenesis (evidenced by Haab's striae, buphthalmos, and epiphora) in one or both eyes with other typical ARS features in the same or other eye were included and screened.
|
27929720 |
2018 |
|
Cavitation
|
0.010 |
Biomarker
|
disease |
BEFREE |
The effects on cavitation and decomposition of ARS by the parameters that affect degradation, including solution temperature, initial pH, and electrolytes, were examined.
|
29958164 |
2018 |
|
ICHTHYOSIS--CHEEK--EYEBROW SYNDROME
|
0.010 |
Biomarker
|
disease |
BEFREE |
Cases of ARS with overlapping features with other ASD, like aniridia (complete or incomplete absence of iris), iridocorneal endothelial (ICE) syndrome (beaten metal appearance of corneal endothelium), Peters anomaly, isolated trabeculodysgenesis (evidenced by Haab's striae, buphthalmos, and epiphora) in one or both eyes with other typical ARS features in the same or other eye were included and screened.
|
27929720 |
2018 |
|
SPASTIC ATAXIA, CHARLEVOIX-SAGUENAY TYPE
|
0.010 |
Biomarker
|
disease |
BEFREE |
The human iPSC cell line, ARS-FiPS4F1 (ESi063-A), derived from dermal fibroblast from the patient autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) caused by mutations on the gene SACSIN, was generated by non-integrative reprogramming technology using OCT3/4, SOX2, CMYC and KLF4 reprogramming factors.
|
30144656 |
2018 |
|
Viral uveitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Atypical features like focal strands with differential corneal involvement and onset of viral uveitis in unclassified ARS suggest a possible viral etiology during different periods of eye development.
|
27929720 |
2018 |
|
Low anterior resection syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Up to 80% of patients after low anterior resection, experience (low) anterior resection syndrome (ARS/LARS).
|
29313107 |
2018 |
|
Connective Tissue Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
As our previous studies revealed that ARS-ILD without PM/DM was similar to CTD-associated ILD, and that ARS-ILD with PM/DM was radiologically suggestive of a nonspecific interstitial pneumonia (NSIP) pathological pattern, we hypothesized that the prognosis of ARS-ILD might be distinct from that of idiopathic pulmonary fibrosis (IPF) without anti-ARS.
|
28461123 |
2017 |
|
Idiopathic Pulmonary Fibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
As our previous studies revealed that ARS-ILD without PM/DM was similar to CTD-associated ILD, and that ARS-ILD with PM/DM was radiologically suggestive of a nonspecific interstitial pneumonia (NSIP) pathological pattern, we hypothesized that the prognosis of ARS-ILD might be distinct from that of idiopathic pulmonary fibrosis (IPF) without anti-ARS.
|
28461123 |
2017 |
|
Autoimmune Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Recent evidence suggests that ARS genes may participate in a wide array of cellular processes, and may contribute to the pathology of autoimmune disease, cancer, and other diseases.
|
27612429 |
2016 |
|
Astrocytoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We measured the expression of RGS-2,-3, and -4 in both transformed glia cells (human U373 MG astrocytoma cells) and in primary rat astrocyte cultures stimulated with adenosine agonists.
|
26263491 |
2015 |
|
Polymyositis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The significantly lower frequency of anti-ARS antibodies and significantly higher frequency of anti-MDA5 antibodies in the Chinese patients were observed in the classic DM subset (14.7 % [10/68] versus 46.4 % [26/56], respectively, P < 0.001, and 45.6 % [31/68] versus 5.4 % [3/56], respectively, P < 0.001) and CADM subset (8.0 % [2/25] versus 28.8 % [15/52], respectively, P = 0.04, and 88.0 % [22/25] versus 44.2 % [23/52], respectively, P = 0.0002), but not in the PM subset.
|
25903820 |
2015 |
|
Childhood Astrocytoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We measured the expression of RGS-2,-3, and -4 in both transformed glia cells (human U373 MG astrocytoma cells) and in primary rat astrocyte cultures stimulated with adenosine agonists.
|
26263491 |
2015 |
|
Peripheral Nervous System Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Interestingly, ARS gene mutations have been implicated in tissue-specific human diseases, including inherited peripheral neuropathies.
|
23465884 |
2013 |
|
Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Interestingly, mRNA expression of steroid sulfatase STS, but not of arylsulfatases ARS-A and ARS-B, was significantly higher (p<0.0017) in non-malignant specimens than in tumor tissue samples, which might explain the higher resveratrol-3-O-sulfate concentrations in breast cancer specimens.
|
19747768 |
2010 |
|
Anxiety
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Rgs 2 gene polymorphisms as modulators of anxiety in humans?
|
16736243 |
2006 |
|
Anxiety Disorders
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Rgs 2 gene polymorphisms as modulators of anxiety in humans?
|
16736243 |
2006 |
|
Keratoderma, Palmoplantar
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We report here a Tunisian family with three siblings presenting with recessive transgressive PPK closely resembling the MDM phenotype that excludes linkage to the ARS gene.
|
16865292 |
2006 |
|
Erythrokeratoderma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Mal de Meleda (MDM) is a rare form of recessive transgressive palmoplantar erythrokeratoderma for which mutations in the ARS gene have been identified recently.
|
15909066 |
2005 |
|
Cardiovascular Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Is RGS-2 a new drug development target in cardiovascular disease?
|
15268629 |
2004 |
|
Hypertensive disease
|
0.010 |
Biomarker
|
group |
BEFREE |
It has been suggested that RGS-2 is a new drug development target for hypertension.
|
15268629 |
2004 |
|
Dermatologic disorders
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Mal de Meleda is an autosomal recessive inflammatory and keratotic palmoplantar skin disorder due to mutations in the ARS B gene, encoding for SLURP-1 (secreted mammalian Ly-6/uPAR-related protein 1).
|
14506129 |
2003 |