|
Childhood Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, 50% of the BCL-6 rearrangement positive lymphoma cases had coexisting gene rearrangements involving all of the aforementioned gene loci.
|
9184180 |
1997 |
|
Childhood Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Follicular lymphoma without t(14;18) and with BCL-6 rearrangement: a lymphoma subtype with distinct pathological, molecular and clinical characteristics.
|
12399977 |
2002 |
|
Childhood Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
There were 47 DTHLs, 36 cases with MYC and BCL2 and/or BCL6 extra signals (ES) and/or rearrangements (ES group, excludes DTHLs), 9 with MYC rearrangements only (single-hit lymphoma), and 95 with no MYC abnormalities (NM).
|
28614202 |
2017 |
|
Childhood Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genetic modifications of the BCL6 gene in lymphoma include translocations, deletions, and somatic mutations (SM) of the 5' noncoding region.
|
16094416 |
2005 |
|
Childhood Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Analysis of the bcl6 noncoding first exon showed somatic mutations in two of four cases analyzed, as would be expected in lymphoma deriving from the germinal center.
|
11420458 |
2001 |
|
Childhood Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mutations of BCL-6 proto-oncogene, a zinc finger transcription factor implicated in lymphoma development, represent a histogenetic marker of B cell transit through the germinal center (GC) and occur frequently in B cell malignancies derived from GC or post-GC B cells.
|
10803511 |
2000 |
|
Childhood Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To identify possible additional breakpoint clusters within 3q27, we cloned a t(3;14)(q27;q32) lymphoma without MBR rearrangement and found a novel breakpoint site located between 245 and 285 kb 5' to BCL-6.
|
12124346 |
2002 |
|
Childhood Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The heterogeneity in partner sites is distinct from other lymphoma subgroups and may suggest that the genetic events are not uniform among patients with BCL6 rearrangements.
|
9402330 |
1997 |
|
Childhood Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Hypermutations at the E1.11 segment of bcl-6 gene were detectable in 16/22 (73%) primary gastric and 4/18 (22%) primary nodal lymphoma (P<0.01).
|
9401082 |
1997 |
|
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Reasoning that disruption of POZ domain-mediated interactions may be an effective route to antagonizing the effects of BCL-6 in lymphoma, we screened a library for peptide aptamers that specifically bind to BCL-6 POZ and not the POZ domains of related proteins and describe here the first of these reagents, Apt48.
|
16331266 |
2006 |
|
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Chromosomal alterations involving 3q27 seem to be responsible for this increased Bcl6 expression, which needs to be considered when Bcl6 is used in lymphoma diagnosis.
|
15252312 |
2004 |
|
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
BCL6 as a therapeutic target for lymphoma.
|
29262721 |
2018 |
|
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Double-color FISH with IgH (Y6) and BCL6 (cosB5-1) showed fusion of BCL6 and IgH genes on der(3)t(3;14) in all nine patients, suggesting that der(3) may play a critical role in the development of lymphoma carrying complex as well as standard t(3;14) translocations.
|
9398863 |
1997 |
|
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
A significant association was seen between lymphoma stage and BCL6 (p=0.045) but not MUM1 expression (p=0.09).
|
25640395 |
2015 |
|
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Several experiments and mouse models mimicking BCL6 translocation occurring in human lymphoma have demonstrated the oncogenic role of BCL6 and constitute a rational to consider BCL6 as a new therapeutic target in NHL.
|
16815642 |
2007 |
|
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Following a broad panel of immunohistochemical stains, the strong positive staining of the spindle cells for LCA (CD45), CD20, and Bcl-6 confirmed the diagnosis of follicle center cell lymphoma.
|
31693188 |
2020 |
|
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, tandem targeting of the overlapping BCL6 and p53 transcriptional programs can correct aberrant survival pathways in DLBCL and might provide an effective therapeutic approach to lymphoma therapy.
|
18451163 |
2008 |
|
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We speculate that the poor outcome of primary adrenal lymphoma might be related to the bulky tumor size at presentation, non-germinal center B-cell phenotype, and frequent BCL-6 gene rearrangement.
|
19525926 |
2009 |
|
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
They were subclassified using CD10, mum-1, bcl-6 as germinal center B-cell like (GCB) lymphoma (30%) and non-GCB lymphoma (70%).
|
19298719 |
2009 |
|
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Simple karyotyping revealed key translocations involving MYC, BCL2, and BCL6 that have impacted lymphoma classification in the World Health Organization classification scheme.
|
30213388 |
2018 |
|
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our studies identify PRMT5 as a novel regulator of the GC reaction and highlight the mechanistic rationale of cotargeting PRMT5 and BCL6 in lymphoma.
|
30082494 |
2018 |
|
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our data confirm ITM2B as a target of BCL6 repression in lymphoma.
|
25557390 |
2015 |
|
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus BCL6 is considered to be involved in germinal center (GC)-derived lymphoma.
|
31063496 |
2019 |
|
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
High grade B-cell lymphoma with rearrangements of MYC and BCL2 and/or BCL6: Double hit and triple hit lymphomas and double expressing lymphoma.
|
27717585 |
2017 |
|
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Reverse transcriptase-mediated polymerase chain reaction revealed chimeric mRNA consisting of two non-coding exons 1a/1b of IL-21R and coding exons of BCL6 in both lymphoma cells.
|
11821949 |
2002 |