|
Leukemogenesis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To investigate whether mutation of the LAZ3 gene might contribute to a potential role for this gene in lymphomagenesis, we screened the coding sequences of 13 rearranged cases, 6 nonrearranged cases, and 13 hematopoietic tumor cell lines.
|
7742550 |
1995 |
|
Leukemogenesis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Because DLCL derive from germinal-center B cells, deregulated BCL-6 expression may contribute to lymphomagenesis by preventing postgerminal center differentiation.
|
7795255 |
1995 |
|
Leukemogenesis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These findings suggest that BCL-6 may play a role in regulating differentiation of normal germinal center B cells and that its deregulated expression caused by rearrangements may contribute to lymphomagenesis.
|
8555467 |
1996 |
|
Leukemogenesis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These alterations identify a mechanism of genetic instability in malignant B cells and may have been selected during lymphomagenesis for their role in altering BCL6 expression.
|
8618933 |
1995 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The frequency of these mutations, as well as their location in the proximity of BCL-6 regulatory sequences, suggest that they may play a role in AIDS-related lymphomagenesis.
|
9160681 |
1997 |
|
Leukemogenesis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of this work was to define the involvement of the bcl-6 gene in AIDS-related lymphomagenesis by investigating the distribution of bcl-6 structural alterations throughout the pathologic spectrum of AIDS-NHL.
|
9209652 |
1997 |
|
Leukemogenesis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The persistent expression of activated BCL6 may contribute to lymphomagenesis by blocking B-cell differentiation within the GC.
|
9427715 |
1998 |
|
Leukemogenesis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The frequency of BCL-6 mutations, as well as their location in the proximity of the BCL-6 regulatory regions, suggest that they may play a pathogenetic role in AIDS-related lymphomagenesis.
|
9720713 |
1998 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Regulation of lymphocyte cell fate decisions and lymphomagenesis by BCL-6.
|
10626250 |
1999 |
|
Leukemogenesis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Promotor substitution leads to deregulation of the BCL6 expression, which may be associated with lymphomagenesis.
|
10953971 |
2000 |
|
Leukemogenesis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest that the acquisition process of bcl-6 mutations by the marginal zone cells may be involved in the lymphomagenesis of the stomach, but our data does not explain the reason why bcl-6 protein is expressed only in high-grade gastric lymphomas.
|
11353050 |
2001 |
|
Leukemogenesis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We suggest that expression of BCL-6 in T cells may facilitate lymphomagenesis by repressing critical cytokines and cell cycle regulators.
|
11742039 |
2001 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The 5' regulatory region of the BCL-6 gene undergoes frequent somatic hypermutation during lymphomagenesis and the identification of BCL-6 gene hypermutations provides a molecular marker for confirmatory diagnosis of B-NHL.
|
11780315 |
2001 |
|
Leukemogenesis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Repression of AP-1 function by BCL-6 may be a key mechanism for how BCL-6 regulates gene expression to control inflammation, lymphocyte differentiation, and lymphomagenesis.
|
12165517 |
2002 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results not only demonstrate an important mechanism governing the expression of BCL-6, but also explain how BCL-6 is deregulated in a large number of DLBCL patients, providing a better understanding of BCL-6-related lymphomagenesis.
|
12407182 |
2002 |
|
Leukemogenesis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This suggests that deregulated expression of BCL-6 may contribute to lymphomagenesis.
|
12469325 |
2002 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In contrast, the study of the 'oncogenic' structural alterations of BCL6 in BNHL and of its cellular functions gives rise to much more heterogeneous data with no obvious unifying picture so that how and even whether BCL6 contributes to lymphomagenesis remains unclear.
|
12555064 |
2003 |
|
Leukemogenesis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Translocations and somatic mutations are common genetic alterations of the BCL-6 gene on chromosome 3q27 in B-cell lymphoma, with implications for lymphomagenesis.
|
12775568 |
2003 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Understanding the precise role of BCL6 in normal GC formation and in lymphomagenesis depends on the identification of genes that are direct targets of its transcriptional repression.
|
12860928 |
2003 |
|
Leukemogenesis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
However, the significance of deregulated expression of BCL6 in lymphomagenesis and its effect on clinical outcomes of lymphoma patients have remained elusive.
|
12881702 |
2003 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
To explore further the mechanisms of action of BCL6 in lymphomagenesis, we developed a transgenic mouse model mimicking a common translocation, the t(3, 14)(q27;q32), in human lymphomas.
|
15375218 |
2004 |
|
Leukemogenesis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These findings to date reveal several mechanisms which can influence specific mutations targeting BCL6, and which may contribute to lymphomagenesis by dysregulating control of BCL6 expression.
|
16019457 |
2005 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The dysregulation of BCL6 has therefore been implicated in lymphomagenesis.
|
16147992 |
2005 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recent studies have shown that the B-cell lymphoma 6 gene (BCL6) is an oncogene that contributes to lymphomagenesis.
|
16264183 |
2005 |
|
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The BCL6 proto-oncogene: a leading role during germinal center development and lymphomagenesis.
|
16815642 |
2007 |