Childhood Non-Hodgkin Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Translocations involving 3q27 that affect the BCL6 gene are common and specific chromosomal abnormalities in B-cell precursor non-Hodgkin lymphoma (mainly diffuse large-cell and follicular lymphoma), but they have not been reported in Burkitt lymphoma.
|
16772123 |
2006 |
Childhood Non-Hodgkin Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The BCL-6 gene is involved in diffuse large-cell lymphoma and overexpressed in other types of non-Hodgkin's lymphoma and in high-grade breast cancer.
|
16331266 |
2006 |
Childhood Non-Hodgkin Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Single nucleotide polymorphism in 5'-flanking region of BCL6 is not associated with increased risk of non-Hodgkin's lymphoma.
|
16125304 |
2006 |
Childhood Non-Hodgkin Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In addition, two other genes, BCL6 and BCL2, which are classically related to apoptosis and non-Hodgkin lymphoma, were shown for the first time to be involved in amplification.
|
15611930 |
2005 |
Childhood Non-Hodgkin Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A putative exonic splicing polymorphism in the BCL6 gene and the risk of non-Hodgkin lymphoma.
|
16264183 |
2005 |
Childhood Non-Hodgkin Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Chromosomal translocation affecting the 3q27 band, where the BCL6 gene is localized, is one of the most common genetic abnormalities in non-Hodgkin's lymphoma of B-cell type (B-NHL).
|
15024721 |
2004 |
Childhood Non-Hodgkin Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In B cell lymphomas, structural alterations of the BCL-6 promoter region, including chromosome translocation and somatic hypermutation, represent the most frequent genetic lesions associated with non-Hodgkin lymphoma, especially of diffuse large cell lymphoma, a malignancy often derived from germinal centre (GC) B cells.
|
12469325 |
2002 |
Childhood Non-Hodgkin Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A recurrent translocation, t(3;6)(q27;p21), in non-Hodgkin's lymphoma results in fusion of BCL6 with a particular histone H4 gene on 6p21.
|
12414651 |
2002 |
Childhood Non-Hodgkin Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Translocations of the BCL-6 gene to heterologous promoters and mutations of its 5'-noncoding regulatory region were reported to be potential mechanisms for deregulating BCL-6 expression and for playing a role in the genesis of non-Hodgkin lymphoma.
|
11290603 |
2001 |
Childhood Non-Hodgkin Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mutation analysis of the 5' noncoding regulatory region of the BCL-6 gene in non-Hodgkin lymphoma: evidence for recurrent mutations and intraclonal heterogeneity.
|
10666217 |
2000 |
Childhood Non-Hodgkin Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In order to elucidate the molecular mechanism(s) for BCL6 translocation, we identified translocational partner genes by subjecting clinical biopsy samples from patients with non-Hodgkin's lymphoma to 5'-rapid amplification of cDNA ends (5'-RACE).
|
10637510 |
1999 |
Childhood Non-Hodgkin Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The t(2;3)(q21;q27) translocation in non-Hodgkin's lymphoma displays BCL6 mutations in the 5' regulatory region and chromosomal breakpoints distant from the gene.
|
9796700 |
1998 |
Childhood Non-Hodgkin Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Chromosomal translocations and/or their molecular equivalents involving the BCL6 gene on 3q27 band have been suggested to be involved in the development of non-Hodgkin's lymphoma of B-cell type (B-NHL).
|
9747876 |
1998 |
Childhood Non-Hodgkin Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Deregulation of BCL6 in non-Hodgkin lymphoma by insertion of IGH sequences in complex translocations involving band 3q27.
|
9824206 |
1998 |
Childhood Non-Hodgkin Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Because H4 gene expression is tightly coupled to DNA replication, this study suggested an immediate mechanism for deregulated expression of BCL6, leading to the development of non-Hodgkin's lymphoma.
|
8988030 |
1997 |
Childhood Non-Hodgkin Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interphase detection of BCL6/IgH fusion gene in non-Hodgkin lymphoma by fluorescence in situ hybridization.
|
9398863 |
1997 |
Childhood Non-Hodgkin Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Small deletions occur in highly conserved regions of the LAZ3/BCL6 major translocation cluster in one case of non-Hodgkin's lymphoma without 3q27 translocation.
|
9047392 |
1997 |
Childhood Non-Hodgkin Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Rearrangements of the BCL6 gene and chromosome aberrations affecting 3q27 in 54 patients with non-Hodgkin's lymphoma.
|
9402330 |
1997 |
Childhood Non-Hodgkin Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The gene was identified by fusion to the BCL6/LAZ3 oncogene in an initially described t(3;4)(q27;p11) translocation in a non-Hodgkin's lymphoma cell line.
|
9226377 |
1997 |
Childhood Non-Hodgkin Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Internal DNA deletion within the BCL-6 gene on untranslocated chromosome in non-Hodgkin's lymphoma with 3q27 abnormality.
|
8618443 |
1996 |
Childhood Non-Hodgkin Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A new non-random chromosomal translocation t(3;6)(q27;p21.3) associated with BCL6 rearrangement in two patients with non-Hodgkin's lymphoma.
|
8923787 |
1996 |
Childhood Non-Hodgkin Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Translocation (3;14)(q27;q11): a new variant translocation in a patient with non-Hodgkin's lymphoma of B-cell type with BCL6 rearrangement.
|
8780747 |
1996 |
Childhood Non-Hodgkin Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
LAZ3 rearrangements in non-Hodgkin's lymphoma: correlation with histology, immunophenotype, karyotype, and clinical outcome in 217 patients.
|
8167331 |
1994 |
Childhood Non-Hodgkin Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Rearrangements of the BCL6 gene in diffuse large cell non-Hodgkin's lymphoma.
|
8142643 |
1994 |
Childhood Non-Hodgkin Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Rearrangements of the BCL-6 gene in acquired immunodeficiency syndrome-associated non-Hodgkin's lymphoma: association with diffuse large-cell subtype.
|
8025268 |
1994 |