RNF6, ring finger protein 6, 6049

N. diseases: 46; N. variants: 4
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.030 Biomarker phenotype BEFREE Further, RNF6 knockdown notably inhibited the metastasis abilities of HCC in vivo and in vitro. 30496760 2019
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.030 Biomarker phenotype BEFREE Biological function of RNF6 on tumor growth and metastasis was detected <i>in vivo</i> and <i>in vitro</i> Role of RNF6 in modulating SHP-1 expression was examined by coimmunoprecipitation and confocal microscopy, respectively.<b>Results:</b> The copy number of RNF6 was significantly amplified in colorectal cancer, and the amplification was associated with RNF6 expression level. 29288235 2018
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.030 GeneticVariation phenotype BEFREE There were no IBTR or RNF (6 y IBTR/RNF rate 0%); however, 2 patients experienced distant metastasis (4% at 6 y). 28787281 2018