|
Alzheimer's Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
PPARGC1A and RORA are involved in circadian rhythm; circadian disturbances are one of the earliest symptoms of Alzheimer's disease.
|
31283791 |
2019 |
|
Arthritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We found that RORα overexpression in CIA mice attenuated the clinical and histological severities of inflammatory arthritis.
|
31636631 |
2019 |
|
Rheumatoid Arthritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, altered RORα activity could directly affect osteoclastogenesis implicated in progressive bone destruction in human RA.
|
31636631 |
2019 |
|
Dermatitis, Atopic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In addition, we report a statistically non-significant change of the CD4+/CD8+ ratio, a dramatic decrease of three gene markers (PIAS1, RORA and SH2B1) as well as a panel of differential expression of cytokines in AD dogs in comparison to the healthy controls.
|
31226136 |
2019 |
|
Kidney Failure, Acute
|
0.010 |
Biomarker
|
disease |
BEFREE |
In summary, our study provides experimental evidence showing that RORα is a novel endogenous protector against renal I/R injury and that ROR-α activation is a promising therapeutic strategy for the prevention of acute kidney injury.-Cai, J., Jiao, X., Fang, Y., Yu, X., Ding, X.
|
30673513 |
2019 |
|
Machado-Joseph Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Pharmacological enhancement of retinoid-related orphan receptor α function mitigates spinocerebellar ataxia type 3 pathology.
|
30343032 |
2019 |
|
Pneumonia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
An efficient memory Th2 cell response is dependent on IL-13 produced by ILC2s, causing allergic lung inflammation and elevated serum levels of immunoglobulin E. ILC2 cells are derived from common lymphoid progenitors and their growing depends on the transcription factor RORA.
|
30539779 |
2019 |
|
Allergic asthma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Other SNVs in RORA were associated with allergy markers, atopic and non-atopic asthma.
|
30539779 |
2019 |
|
Intestinal infectious disease (disorder)
|
0.010 |
Biomarker
|
group |
BEFREE |
The Transcription Factor RORα Preserves ILC3 Lineage Identity and Function during Chronic Intestinal Infection.
|
31676672 |
2019 |
|
bone destruction
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, altered RORα activity could directly affect osteoclastogenesis implicated in progressive bone destruction in human RA.
|
31636631 |
2019 |
|
Metastatic melanoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In summary, our study indicates that the expression of VDR, RORα and RORγ in melanomas is related to hypoxia and/or HIF1-α activity, which also affects FoxP3 expression in metastatic melanoma.
|
31287590 |
2019 |
|
Malignant neoplasm of kidney
|
0.010 |
Biomarker
|
disease |
BEFREE |
Analysis of TCGA data indicated that the overexpression of Per1-3, Cry2, CLOCK, NR1D2 and RORA with underexpression of Timeless and NPAS2 was associated with a favorable prognosis in kidney cancer.
|
31014126 |
2019 |
|
Renal carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Analysis of TCGA data indicated that the overexpression of Per1-3, Cry2, CLOCK, NR1D2 and RORA with underexpression of Timeless and NPAS2 was associated with a favorable prognosis in kidney cancer.
|
31014126 |
2019 |
|
Benign Prostatic Hyperplasia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In the present study we evaluated genotype and allele frequencies of rs11639084 and rs4774388 variants within RORA gene in PCa and BPH patients compared with healthy subjects.
|
30251751 |
2019 |
|
IgE-mediated allergic asthma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Other SNVs in RORA were associated with allergy markers, atopic and non-atopic asthma.
|
30539779 |
2019 |
|
Pneumonitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
An efficient memory Th2 cell response is dependent on IL-13 produced by ILC2s, causing allergic lung inflammation and elevated serum levels of immunoglobulin E. ILC2 cells are derived from common lymphoid progenitors and their growing depends on the transcription factor RORA.
|
30539779 |
2019 |
|
Autoimmune Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
The orphan nuclear receptors retinoic acid-related receptor α and γt (RORα and RORγt) are critical in the development of T helper 17 (Th17) cells, and ROR-specific synthetic ligands have proven efficacy in several mouse models of autoimmunity.
|
30189901 |
2018 |
|
Malignant neoplasm of endometrium
|
0.010 |
Biomarker
|
disease |
BEFREE |
Further experiments indicated miR-652 overexpression can activate the Wnt/β-catenin pathway and RORA can downregulate β-catenin and function as a tumor suppressor in endometrial cancer.
|
30093563 |
2018 |
|
Squamous cell carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
MicroRNA-transcription factor network analysis reveals miRNAs cooperatively suppress RORA in oral squamous cell carcinoma.
|
30293994 |
2018 |
|
Cerebellar Ataxia
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Dual Molecular Effects of Dominant RORA Mutations Cause Two Variants of Syndromic Intellectual Disability with Either Autism or Cerebellar Ataxia.
|
29656859 |
2018 |
|
Colorectal Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Furthermore, RNA-seq data showed that the mRNA levels of RORA were significantly lower in colorectal tumors than the paired normal tissues.
|
29968159 |
2018 |
|
Neuralgia
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
We identified four common SNPs representing four genomic regions: 7q22.3 (rs10950641; SNX8; P = 3.39 × 10<sup>-14</sup>), 19p13.2 (rs4804217; PCP2; P = 2.95 × 10<sup>-9</sup>), 3q27.3 (rs6796803; KNG1; P = 6.42 × 10<sup>-9</sup>) and 15q22.2 (rs4775319; RORA; P = 1.02 × 10<sup>-8</sup>), suggesting SNX8, PCP2, KNG1 and RORA might be novel target genes for NP in patients with head and neck cancer.
|
29884837 |
2018 |
|
Primary Sjögren's syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our data reveal the importance of RORα in controlling pathologic lymphocytic infiltration of the salivary glands and suggest that RORα may be a druggable target in treating pSS.
|
30189901 |
2018 |
|
Cutaneous Melanoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Genetic variants in RORA and DNMT1 associated with cutaneous melanoma survival.
|
29313974 |
2018 |
|
Malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Out of 17 genes investigated, 15 were found to be significantly associated with the risk of cancer: four genes were shared by all three malignancies (ARNTL, CLOCK, RORA and RORB), two by breast and lung cancer (CRY1 and CRY2) and three by prostate and lung cancer (NPAS2, NR1D1 and PER3), whereas four genes were specific for lung cancer (ARNTL2, CSNK1E, NR1D2 and PER2) and two for breast cancer (PER1, RORC).
|
29455641 |
2018 |