RORA, RAR related orphan receptor A, 6095

N. diseases: 158; N. variants: 54
Disease: Bipolar Disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.340 GeneticVariation disease BEFREE In secondary analyses, HTR2A (rs643627, p = 0.002) and CHL1 (rs4003413, p = 0.002) were found associated with risk for BD, HOMER1 (rs6872497, p = 0.002) with lifetime history of suicide attempt in patients, and RORA with early onset and presence of psychotic features in BD. 30178121 2018
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.340 GeneticVariation disease BEFREE The current study aimed to investigate the relationships between genetic variants in NR1D1 RORA, and RORB genes and BD in the Han Chinese population. 25789810 2015
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.340 Biomarker disease PSYGENET Altogether, these findings suggest that these variants in the TIMELESS and RORA genes may confer susceptibility to BD and impact on circadian phenotypes in carriers who thus had lower ability to properly adapt to external cues. 24716566 2014
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.340 GeneticVariation disease BEFREE Altogether, these findings suggest that these variants in the TIMELESS and RORA genes may confer susceptibility to BD and impact on circadian phenotypes in carriers who thus had lower ability to properly adapt to external cues. 24716566 2014
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.340 Biomarker disease PSYGENET Analysis of clock gene variants revealed that PER3 and RORA genotype predicted period lengthening by Li, whereas GSK3β genotype predicted rhythm effects of Li, specifically among BD cases. 24150227 2013
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.340 Biomarker disease PSYGENET The findings that have gained support indicate that genetic variants of RORA (rs2028122) and CRY1 (rs2287161) associate with depressive disorder, those of RORB (rs7022435, rs3750420, rs1157358, rs3903529) and NR1D1 (rs2314339) with bipolar disorder, and those of NPAS2 (rs11541353) and CRY2 (rs10838524) with seasonal affective disorder or winter depression. 22538398 2012
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.340 GeneticVariation disease BEFREE The findings that have gained support indicate that genetic variants of RORA (rs2028122) and CRY1 (rs2287161) associate with depressive disorder, those of RORB (rs7022435, rs3750420, rs1157358, rs3903529) and NR1D1 (rs2314339) with bipolar disorder, and those of NPAS2 (rs11541353) and CRY2 (rs10838524) with seasonal affective disorder or winter depression. 22538398 2012
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.340 Biomarker disease PSYGENET Genetic and metabolic characterization of insomnia. 21494683 2011
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.340 Biomarker disease PSYGENET We examined 209 single-nucleotide polymorphisms (SNPs) covering 19 circadian genes (ADCYAP1, ARNTL, ARNTL2, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1E, DBP, NPAS2, NR1D1, PER1, PER2, PER3, RORA, TIMELESS, VIP, and VIPR2) in a sample of 534 MD patients (335 with unipolar major mood depression (MDD) and 199 with bipolar disorder (BD)) and 440 community-based screened controls. 20072116 2010