RORC, RAR related orphan receptor C, 6097

N. diseases: 88; N. variants: 6
Disease: Obesity ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0028754
Disease: Obesity
Obesity 		0.050 Biomarker disease BEFREE TOR conservation from flies to humans indicates that probiotic therapy with L. fermentum NCIMB 5221 has a high therapeutic potential towards several human energy regulatory diseases such as obesity, diabetes and cancer. 30368647 2019
CUI: C0028754
Disease: Obesity
Obesity 		0.050 Biomarker disease BEFREE TOR is a master regulator of the cell's growth and metabolic state, and its dysregulation contributes to a variety of diseases, including diabetes, obesity, neurodegenerative disorders, aging, and cancer, making the TOR pathway an attractive therapeutic target. 28888322 2017
CUI: C0028754
Disease: Obesity
Obesity 		0.050 Biomarker disease BEFREE Adipogenesis and insulin sensitivity in obesity are regulated by retinoid-related orphan receptor gamma. 21853531 2011
CUI: C0028754
Disease: Obesity
Obesity 		0.050 Biomarker disease BEFREE Obesity and nutrient sensing TOR pathway in flies and vertebrates: Functional conservation of genetic mechanisms. 21216618 2011
CUI: C0028754
Disease: Obesity
Obesity 		0.050 Biomarker disease BEFREE High-fat-diet-induced obesity and heart dysfunction are regulated by the TOR pathway in Drosophila. 21035763 2010