Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data reveal that cearoin induces autophagy, ERK activation and apoptosis in neuroblastoma SH-SY5Y cells, which is mediated primarily by ROS generation, suggesting its therapeutic application for the treatment of neuroblastomas.
|
28178193 |
2017 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
When neuroblastoma SH-SY5Y cells were pre-conditioned with 100% RAA-MSC media, then treated with H<sub>2</sub>O<sub>2</sub> and 6-OHDA, mortality and ROS generation were reduced.
|
28965958 |
2017 |
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Sustained <i>O-</i>GlcNAc elevation in SH-SY5Y neuroblastoma cells increased OGA expression and reduced cellular respiration and ROS generation.
|
28739801 |
2017 |
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The next-generation ALK/ROS1 inhibitor PF-06463922 exerts unparalleled activity in ALK-driven neuroblastoma models with primary crizotinib resistance.
|
26554404 |
2016 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We wanted to determine if entrectinib (RXDX-101, Ignyta, Inc.), an oral Pan-Trk, Alk and Ros1 inhibitor, was effective in our NB model.
|
26797418 |
2016 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Over-expression of PAR-4 gene was accompanied by aberrant Abeta production followed by ROS generation and subsequent death of neuroblastoma cells used in the present study as a cellular model for neurons.
|
20927647 |
2010 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In rat neuroblastoma cells (IMR-32), we used Abeta(1-42), in which the Met-35 is present in the reduced state, with a modified peptide with oxidized Met-35 (Abeta(1-42)Met35(OX)), as well as an Abeta-derivative in which Met-35 is substituted with norleucine (Abeta(1-42)Nle35) to investigate the relationship between Met-35 redox state, expression and function of MsrA and reactive oxygen species (ROS) generation.
|
20060866 |
2010 |
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
SAG protects human neuroblastoma SH-SY5Y cells against 1-methyl-4-phenylpyridinium ion (MPP+)-induced cytotoxicity via the downregulation of ROS generation and JNK signaling.
|
17240529 |
2007 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These present findings support the hypothesis that morphine can inhibit DOX-induced neuroblastoma cell apoptosis by the inhibition of ROS generation and mitochondrial cytochrome c release, as well as by blockade of NF-kappaB transcriptional activation, and suggests that morphine might have an impact on the antitumour efficiency of DOX.
|
17542780 |
2007 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Astrocytoma cells, not neuroblastoma cells, were responsive to Cu and Cu elevation was associated with ROS generation.
|
15836927 |
2005 |