RPA1, replication protein A1, 6117

N. diseases: 59; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0152018
Disease: Esophageal carcinoma
Esophageal carcinoma
0.030 Biomarker disease BEFREE Recently, some studies focusing on the relation between RPA1 and carcinogenesis have demonstrated that RPA1 is a candidate oncogene and influences tumor biological behaviors in many cancers such as esophageal carcinoma, colon cancer, urothelial carcinomas, etc. 29477843 2018
CUI: C0152018
Disease: Esophageal carcinoma
Esophageal carcinoma
0.030 AlteredExpression disease BEFREE The RPA1 expression in esophageal carcinoma was significantly higher than that in the tumor-adjacent tissues, which was associated with tumor invasion and lymph node metastasis. 26824734 2015
CUI: C0152018
Disease: Esophageal carcinoma
Esophageal carcinoma
0.030 Biomarker disease BEFREE Post transcriptional silencing of RPA1 or -2 via RNAi can enhance the radiosensitivity of human esophageal cancer cells TE-1R, and the potential mechanism may be related to the inhibition of post-radiation sublethal damage repair and the halted cell cycle progression at G2/M phase. 24789547 2014