|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have investigated a transcriptome-wide analysis of differential gene expression, single-nucleotide polymorphisms (SNPs), indels, and simple sequence repeats (SSRs) in datasets of the human peripheral retina and RPE-choroid-sclera control and AMD.
|
30894217 |
2019 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, oxLDL, Hcy, HCTL and AGE act as pro-oxidant metabolites in RPE that promote AMD through oxidative stress, inflammation, chemotaxis and neovascularization.
|
31086404 |
2019 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
Increased fundus autofluorescence is directly related to increased RPE lipofuscin deposition in the retina and has been observed in eyes with age-related macular degeneration (AMD).
|
30991052 |
2019 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
Elemental concentrations in Choroid-RPE and retina of human eyes with age-related macular degeneration.
|
31271759 |
2019 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
To detect characteristic patterns found en face in RPE with the same structures in histological cross sections from eyes from cadavers of patients with AMD.
|
30820143 |
2019 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
Strong experimental evidence from studies of human donors with AMD supports the emerging hypothesis that defects in RPE mitochondria drive AMD pathology.
|
30025108 |
2018 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
This simple and efficient approach provides human RPE generation for developing therapies for diseases such as age-related macular degeneration.
|
29574166 |
2018 |
|
Age related macular degeneration
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Evidence presented in this study provides new data regarding the interpretation of published results reporting NLRP3 expression and upregulation in RPE and addresses the role that this inflammasome plays in AMD pathogenesis.
|
29323137 |
2018 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings together with evidence from human genetics and AMD pathology suggest that RPE-generated HDL may contribute lipid to SDDs.
|
30076206 |
2018 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
Dynamic expression of E1, E2 and E3 enzymes were found during the time course of RPE and retina degeneration, which revealed the potential regulatory roles of sumoylation in AMD pathogenesis.
|
30636606 |
2018 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
The thickness of the outer retina showed statistically significant thickening in the foveal region in only the intermediate AMD group and a statistically significant thickening of the RPE in early and intermediate AMD groups in the central retina.
|
29135322 |
2018 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
Strand specific RNA sequencing of both peripheral retina (PR) and RPE-Choroid-Sclera (PRCS), in both AMD and matched normal controls were generated.
|
29445097 |
2018 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
RPE from dry AMD globes, genetically engineered mice lacking Cryba1 globally or specifically in the RPE, spontaneous mutant rats (Nuc1) with a loss-of-function mutation in Cryba1, and the melanoma OCM3 cell line were used.
|
30098172 |
2018 |
|
Age related macular degeneration
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To correlate in vivo imaging to histology in an eye with macular atrophy owing to age-related macular degeneration (AMD; complete retinal pigment epithelium [RPE] and outer retinal atrophy [cRORA]) to evaluate the utility of new optical coherence tomography (OCT) suggested by previous histology.
|
29981740 |
2018 |
|
Age related macular degeneration
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Autophagy deficiency induced by RPE-specific deletion of <i>Atg5</i> or <i>Atg7</i> predisposes but does not necessarily drive the development of AMD-like phenotypes or retinal degeneration.
|
28465655 |
2017 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
Tears of the RPE occur as frequently as in exudative AMD without SMH.
|
28280989 |
2017 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
Even if no direct correlation between A2E spatial distribution and lipofuscin fluorescence has been established in aged human RPE, modified forms or metabolites of A2E could be involved in ARMD pathology.
|
28298893 |
2017 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
A major problem in macular degeneration is the inability to reduce RPE and photoreceptor death.
|
28346613 |
2017 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interestingly, RPE-specific up-regulation in the expression of several complement genes was also seen in patient hiPSC-RPE cultures of all three MDs (SFD, DHRD, and ADRD).
|
28878022 |
2017 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
In particular, since CD5L is known to stimulate autophagy and to participate in oxidized LDL uptake in macrophages, we propose that anti-CD5L/AIM auto-antibodies may play a role in drusen biogenesis and inflammatory RPE damage in AMD.
|
27989757 |
2017 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
Early Onset Ultrastructural and Functional Defects in RPE and Photoreceptors of a Stargardt-Like Macular Dystrophy (STGD3) Transgenic Mouse Model.
|
26529045 |
2015 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
Because A2E accumulation in the RPE is associated with pathogenesis of both Stargardt disease and age-related macular degeneration (AMD) in humans, deletion of Abca4 was introduced into Atg7(flox/flox);VMD2-rtTA-cre+ mice to investigate the role of autophagy during A2E accumulation.
|
26468292 |
2015 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
RPE of eyes affected by geographic atrophy or neovascular AMD exhibited NLRP3 staining at lesion sites.
|
23221073 |
2013 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
The accumulation of damaged or postsynthetically modified proteins and dysregulation of inflammatory responses and angiogenesis in the retina/RPE are thought be etiologically related to formation of drusen and choroidal neovascularization (CNV), hallmarks of age-related macular degeneration (AMD).
|
22521794 |
2012 |