BCR, BCR activator of RhoGEF and GTPase, 613

N. diseases: 392; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.320 GeneticVariation disease BEFREE We previously reported a significant association between genetic variations in the breakpoint cluster region (BCR) gene and bipolar disorder. 17822820 2008
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.320 Biomarker disease PSYGENET We previously reported a significant association between genetic variations in the breakpoint cluster region (BCR) gene and bipolar disorder. 17822820 2008
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.320 Biomarker disease PSYGENET The positional candidate approach showed an association between bipolar disorder and TRPM2 (21q22.3), GPR50 (Xq28), Citron (12q24), CHMP1.5 (18p11.2), GCHI (14q22-24), MLC1 (22q13), GABRA5 (15q11-q13), BCR (22q11), CUX2, FLJ32356 (12q23-q24), and NAPG (18p11). 17239033 2007
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.320 Biomarker disease PSYGENET Various other protein products of genes associated with bipolar disorder either bind to or are affected by phosphatidyl-inositol phosphate products of this pathway (ADBRK2, HIP1R, KCNQ2, RGS4, WFS1), are associated with its constituent elements (BCR, DUSP6, FAT, GNAZ) or are downstream targets of this signalling cascade (DPYSL2, DRD3, GAD1, G6PD, GCH1, KCNQ2, NOS3, SLC6A3, SLC6A4, SST, TH, TIMELESS). 17239488 2007
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.320 GeneticVariation disease BEFREE Our results suggest that genetic variations in the BCR gene could confer susceptibility to bipolar disorder and major depressive disorder. 15866548 2005
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.320 Biomarker disease PSYGENET Our results suggest that genetic variations in the BCR gene could confer susceptibility to bipolar disorder and major depressive disorder. 15866548 2005