Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Childhood Acute Lymphoblastic Leukemia
0.400 GeneticVariation disease BEFREE Of the total 631 cases, 52.9% (n=334) were acute lymphoblastic leukemia (ALL), 43.9% (n=277) acute myeloid leukemia (AML), 2.2% (n=14) mixed phenotypic acute leukemia (MPAL), 0.5% (n=3) acute undifferentiated leukemia (AUL) and 0.5% (n=3) chronic myeloid leukemia in blast crisis (CML-BC). 30858955 2019
Childhood Acute Lymphoblastic Leukemia
0.400 GeneticVariation disease BEFREE At the 60<sup>th</sup> month, estimated CBMR and CEMR incidences were, respectively, 14.3 (5.1)% and 25.9 (6.6)% in ALL, 25.8 (5.9)% and 15.5 (4.8)% in AML, and 61.5 (16.5)% and 17.9 (13.4)% in CML. 30116013 2019
Childhood Acute Lymphoblastic Leukemia
0.400 GeneticVariation disease BEFREE We searched for original articles and reviews describing the pharmacology and clinical use of dasatinib in ALL with BCR-ABL1. 30916583 2019
Childhood Acute Lymphoblastic Leukemia
0.400 Biomarker disease BEFREE BCR-ABL1 signal patterns were analyzed using FISH in 243 CML-chronic phase (CML-CP), 17 CML-blast phase (CML-BP) and 52 BCR-ABL1 positive acute lymphoblastic leukemia (ALL) patients. 31594548 2019
Childhood Acute Lymphoblastic Leukemia
0.400 GeneticVariation disease BEFREE To address this, we studied 142 adults with ALL treated with hyperCVAD over a 10-year period who had MRD assessed by either multi-parameter flow cytometry or (for patients with Philadelphia chromosome positive ALL) reverse transcriptase polymerase chain reaction for the BCR-ABL1 translocation. 29318644 2018
Childhood Acute Lymphoblastic Leukemia
0.400 Biomarker disease BEFREE Pediatric ALL had higher prevalence of ETV6-RUNX1, TCF3-PBX1, and STIL-TAL1, while BCR-ABL1 and SET-NUP214 were more common in adult ALL. 30125757 2018
Childhood Acute Lymphoblastic Leukemia
0.400 GeneticVariation disease BEFREE CD25 (IL-2RA) and CD26 (DPPIV) were expressed on LSCs in Ph<sup>+</sup> ALL exhibiting BCR/ABL1<sub>p210</sub>, whereas in Ph<sup>+</sup> ALL with BCR/ABL1<sub>p190</sub>, LSCs variably expressed CD25 but did not express CD26. 29772458 2018
Childhood Acute Lymphoblastic Leukemia
0.400 AlteredExpression disease BEFREE Philadelphia chromosome-positive (Ph+) B-cell precursor acute lymphoblastic leukemia (ALL) expressing BCR-ABL1 oncoprotein is a major subclass of ALL with poor prognosis. 28579617 2018
Childhood Acute Lymphoblastic Leukemia
0.400 Biomarker disease BEFREE Phosphatase of regenerating liver-3 <i>(PRL-3/PTP4A3)</i> is upregulated in multiple cancers, including BCR-ABL1- and ETV6-RUNX-positive acute lymphoblastic leukemia (ALL). 29423065 2018
Childhood Acute Lymphoblastic Leukemia
0.400 Biomarker disease BEFREE To our knowledge, this is the first successful use of nilotinib in BCR-ABL1-like phenotype ALL. 30121665 2018
Childhood Acute Lymphoblastic Leukemia
0.400 Biomarker disease BEFREE This case illustrates the major interest of interphase FISH for BCR-ABL1 rearrangement on blood neutrophils as a decisive method to discriminate a lymphoid blast crisis of CML from a de novo BCR-ABL1 positive ALL. 28444777 2018
Childhood Acute Lymphoblastic Leukemia
0.400 Biomarker disease BEFREE E14a3 breakpoint cluster region (BCR)/ABL proto-oncogene 1, non-receptor tyrosine kinase (ABL) fusion transcript is rare in Philadelphia chromosome positive disease, particularly in acute lymphoblastic leukemia (ALL). 29434963 2018
Childhood Acute Lymphoblastic Leukemia
0.400 GeneticVariation disease BEFREE Of particular importance is the translocation t(9;22)(q34;q11.2) that leads to the formation of the BCR-ABL1 fusion gene, encoding a constitutively active chimeric tyrosine kinase (TK): BCR-ABL1 that is present in ~3% of pediatric ALL patients with B-immunophenotype and is associated with a poor outcome. 28748759 2018
Childhood Acute Lymphoblastic Leukemia
0.400 AlteredExpression disease BEFREE Although "paired box 5" (PAX5)-related fusion genes are well documented in childhood B-cell precursor acute lymphoblastic leukemia (ALL), these types of fusion with the exception of PAX5-JAK2 are rarely seen in patients with gene expression profiles similar to those of BCR-ABL1 (Philadelphia)-positive ALL (Ph-like ALL). 27870151 2017
Childhood Acute Lymphoblastic Leukemia
0.400 GeneticVariation disease BEFREE We investigated the frequency, predictors, and evolution of acute lymphoblastic leukemia (ALL) in patients with CNS relapse and introduced a novel method for studying BCR-ABL1 protein variants in cDNA from bone marrow (BM) and cerebrospinal fluid (CSF) blast cells. 28451802 2017
Childhood Acute Lymphoblastic Leukemia
0.400 GeneticVariation disease BEFREE Fusion genes were detected by F-qRT-PCR in 97.3% of patients with CML, followed by 69.4% with AML, 33.3% with acute lymphoblastic leukemia (ALL), 9.1% with myelodysplastic syndromes (MDS), and 0% with chronic lymphocytic leukemia (CLL). 28743306 2017
Childhood Acute Lymphoblastic Leukemia
0.400 Biomarker disease BEFREE Genetic alterations of IKZF1 encoding the lymphoid transcription factor IKAROS are a hallmark of high-risk B-progenitor acute lymphoblastic leukemia (ALL), such as BCR-ABL1-positive (Ph+) and Ph-like ALL, and are associated with poor outcome even in the era of contemporary chemotherapy incorporating tyrosine kinase inhibitors. 27865806 2017
Childhood Acute Lymphoblastic Leukemia
0.400 Biomarker disease BEFREE Therefore, we recommend further investigations on CML-like <i>BCR-ABL1</i>-positive ALL. 28331056 2017
Childhood Acute Lymphoblastic Leukemia
0.400 GeneticVariation disease BEFREE To characterize the subset of ALL with normal karyotype or failed CBA, we performed fluorescence in situ hybridization (FISH) or PCR for BCR-ABL1 and MLL rearrangements as well as array comparative genomic hybridization (aCGH) in 186 adult patients. 26449660 2016
Childhood Acute Lymphoblastic Leukemia
0.400 Biomarker disease BEFREE In 16 samples of normal karyotype ALL (n=9), ALL with no cytogentic result (n=4) and CML with no Philadelphia chromosome (n=3), fusion transcripts were detected. 26925663 2016
Childhood Acute Lymphoblastic Leukemia
0.400 GeneticVariation disease BEFREE We demonstrated the dPCR is high-sensitive (able to detect a single copy of BCR-ABL1) and reliable (results are comparable to those obtained by BCR-ABL1 quantification with conventional technology), allowing an accurate monitoring of BCR-ABL1-positive ALL patients in complete remission. 24630366 2014
Childhood Acute Lymphoblastic Leukemia
0.400 Biomarker disease BEFREE Two models of leukemia were used, one genetic (conditional alpha4 ablation of BCR-ABL1 [p210(+)] leukemia) and one pharmacological (anti-functional alpha4 antibody treatment of primary ALL). 23319569 2013
Childhood Acute Lymphoblastic Leukemia
0.400 Biomarker disease BEFREE One recently identified subtype of pediatric B-precursor acute lymphoblastic leukemia (ALL) has been termed BCR-ABL1-like or Ph-like because of similarity of the gene expression profile to BCR-ABL1 positive ALL suggesting the presence of lesions activating tyrosine kinases, frequent alteration of IKZF1, and poor outcome. 23212523 2013
Childhood Acute Lymphoblastic Leukemia
0.400 Biomarker disease BEFREE As tyrosine kinase inhibitors (TKIs) fail to induce long-term response in blast crisis chronic myelogenous leukemia (CML-BC) and Philadelphia chromosome-positive (Ph(+)) acute lymphoblastic leukemia (ALL), novel therapies targeting leukemia-dysregulated pathways are necessary. 23970380 2013
Childhood Acute Lymphoblastic Leukemia
0.400 GeneticVariation disease BEFREE Chronic myelogenous leukemia (CML) and Philadelphia chromosome-positive (Ph(+)) acute lymphoblastic leukemia (ALL) are associated with fusion of the BCR and ABL1 genes by chromosome translocation. 22749885 2012