|
Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
ABL-class fusions other than BCR-ABL1 characterize about 2-3% of precursor B-cell acute lymphoblastic leukemia.
|
31601692 |
2019 |
|
Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Since γ-catenin was dispensable for normal hematopoiesis, these lineage- and disease-specific features of canonical Wnt signaling identified a potential therapeutic target for the treatment of BCR-ABL1<sup>+</sup> B-ALL.
|
30991025 |
2019 |
|
Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
This manuscript highlights a clinically available alternative method for identifying a large subset of patients with BCR-ABL1-like B-ALL.
|
30181314 |
2019 |
|
Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The vast majority of BCR‑ABL1+ leukemic cells were found to be immature B cells with a variable proportion of pro‑B and pre‑B populations.
|
31173268 |
2019 |
|
Precursor B-cell lymphoblastic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We exclusively detect E1A-associated protein p300 (EP300)-ZNF384 in 5.7% of BCR-ABL1-negative adolescent/young adult (AYA)/adult pre-B-ALL patients.
|
29531323 |
2018 |
|
Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Ptpn11 deletion impairs initiation and maintenance of CML-like myeloproliferative neoplasm, and compromises induction of BCR-ABL1<sup>+</sup> B-ALL.
|
28804122 |
2018 |
|
Precursor B-cell lymphoblastic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A novel <i>BCR-ABL1</i> mutation in a patient with Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia.
|
30584318 |
2018 |
|
Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
High-risk subtypes of B-cell acute lymphoblastic leukemia (B-ALL) include Philadelphia chromosome-positive (Ph+) B-ALL driven by the <i>BCR-ABL1</i> oncogene and a more recently identified subtype known as <i>BCR-ABL</i>-like or Ph-like B-ALL.
|
29464092 |
2018 |
|
Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Overall, our results define miR-17/92 as a downstream effector of FGFR1 in BCR-FGFR1-driven B-cell lymphoblastic leukemia.
|
29367757 |
2018 |
|
Precursor B-cell lymphoblastic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The aberrant expression and mutation of CFTR have been observed in several tumor, but not in philadelphia chromosome-positive(Ph+) acute leukemia, including Ph+ B cell acute lymphoblastic leukemia(Ph+ B-ALL) and chronic myelogenous leukemia blast crisis phases (CML-BC).
|
28445932 |
2017 |
|
Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our meta-analysis suggests that IKZF1 deletion is a poor prognostic factor for adults with B cell ALL and may be more valuable in BCR-ABL1-negative B cell ALL patients.
|
27815723 |
2017 |
|
Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
BCR-ABL1(+) precursor B-cell acute lymphoblastic leukemia (BCR-ABL1(+) B-ALL) is an aggressive hematopoietic neoplasm characterized by a block in differentiation due in part to the somatic loss of transcription factors required for B-cell development.
|
25775523 |
2015 |
|
Precursor B-cell lymphoblastic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Expression of CD25 is a specific and relatively sensitive marker for the Philadelphia chromosome (BCR-ABL1) translocation in pediatric B acute lymphoblastic leukemia.
|
25337274 |
2014 |
|
Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
A 74-year-old man was previously diagnosed with BCR-ABL1-positive pre-B cell acute lymphoblastic leukaemia (pre-B ALL) based on bone marrow cytology, flow cytometry, cytogenetics and fluorescent in situ hybridisation findings.
|
24729118 |
2014 |
|
Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
A diagnosis of BCR-ABL1 (p190)-positive and ETV6-RUNX1-positive B-ALL was made, and treatment was initiated according to the AIEOP-BFM-ALL2000 protocol.
|
23491079 |
2013 |
|
Precursor B-cell lymphoblastic leukemia
|
0.400 |
FusionGene
|
disease |
ORPHANET |
A diagnosis of BCR-ABL1 (p190)-positive and ETV6-RUNX1-positive B-ALL was made, and treatment was initiated according to the AIEOP-BFM-ALL2000 protocol.
|
23491079 |
2013 |
|
Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The presence of the type A fusion transcript strongly implies ALL manifestation in ETV6/ABL1-positive hematologic malignancies as minor BCR breakpoint in BCR/ABL1-positive ALL.
|
23171811 |
2013 |
|
Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
We review the literature where only 2 similar cases with normal karyotype Pre-B ALL and associated FISH BCR/ABL1 numerical abnormalities were found.
|
23098889 |
2013 |
|
Precursor B-cell lymphoblastic leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
However, BCR-ABL1 was expressed and active in Stat5-null leukemic stem cells, and Stat5 deletion did not prevent progression to lymphoid blast crisis or abolish established B-cell acute lymphoblastic leukemia.
|
22234689 |
2012 |
|
Precursor B-cell lymphoblastic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The abnormal Ph chromosome, which arises from a translocation creating the BCR-ABL1 fusion gene, is most commonly associated with chronic myelogenous leukemia (CML) and precursor B cell acute lymphoblastic leukemia (B-ALL).
|
21884299 |
2011 |
|
Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Co-expression of CD66c(+) CD13(+) was more frequent in BCR/ABL1(+) B-ALL (29%) than BCR/ABL1(-) cases (4%) (P = 0.0044).
|
20666852 |
2011 |
|
Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Chromosomal rearrangements involving the ABL1 gene, leading to a BCR-ABL1 fusion gene, have been mainly associated with chronic myeloid leukemia and B-cell acute lymphoblastic leukemia (ALL).
|
21435002 |
2011 |
|
Precursor B-cell lymphoblastic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Here we describe a fifth case of ABL1 deletion without BCR/ABL1 rearrangement in an adolescent patient with precursor B-cell lymphoblastic leukemia (B-ALL) and review the relevant literature.
|
20082857 |
2010 |
|
Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The BCR-ABL1 fusion kinase is frequently associated with chronic myeloid leukemia and B-cell acute lymphoblastic leukemia but is rare in T-cell acute lymphoblastic leukemia (T-ALL).
|
15713800 |
2005 |
|
Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
These findings suggest a role for the pre-BCR complex in the response of ALL cells to treatment and provide insight into the mechanism of steroid response in the treatment of pre-B ALL.
|
12154021 |
2002 |