Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Mechanistically, LuCSC transitioning from self-renewal (β-catenin and Nanog signaling) to malignant lineage differentiation is regulated by EGFR activation and the inverse inhibition of tumor suppressor MIG6.
|
31069016 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Next AAV-9 encoding Mitogen inducible gene 6 (Mig-6) was delivered into VX2 liver transplant tumor of rabbits by using hepatic artery catheter.
|
30854112 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
MIG-6 mediates P4 signaling and acts as a tumor suppressor during endometrial tumorigenesis in both humans and mice.
|
30773264 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We showed that Mig-6 has an important function of tumor suppressor via inhibition of STAT3 phosphorylation in uterine epithelial cells, and the antitumor effects of P4 are mediated by the endometrial stroma.
|
28925396 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Previous studies have reported the involvement of mitogen-inducible gene 6 (MIG-6) as a negative regulator in tumor formation.
|
28734040 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The Tumor Suppressor MIG6 Controls Mitotic Progression and the G2/M DNA Damage Checkpoint by Stabilizing the WEE1 Kinase.
|
30067982 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Thus, MIG-6 has a tumor suppressor function in endometrial tumorigenesis.
|
27910070 |
2017 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The ablation of Mig-6 has been shown to induce tumor formation in various tissues.
|
28506767 |
2017 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Knockdown of MIG6 enhanced tumor cell growth under hypoxic conditions, and promoted the phosphorylation of ERK and AKT via increased EGFR-HER3 binding.
|
27893711 |
2017 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This study extends our understanding of EGFR regulation by MIG6 and reveals that MIG6 antagonizes tumor formation in mutant EGFR-driven lung adenocarcinoma.
|
25941338 |
2015 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In line with the paradoxical function of EGFR through EMT and metastasis we demonstrate that the EGFR inhibitory molecule, Mitogen Induced Gene-6 (Mig6), is tumor suppressive in in situ tumor cells.
|
25622905 |
2015 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Mitogen-inducible gene-6 (MIG-6) is a potent inhibitor of the EGFR and has been demonstrated to function as a tumor suppressor.
|
26065894 |
2015 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This study demonstrates that MIG6 is a potent tumor suppressor for mutant EGFR-driven lung tumor initiation and progression in mice and provides a possible mechanism by which mutant EGFR can partially circumvent this tumor suppressor in human lung adenocarcinoma.
|
25735773 |
2015 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Researches regarding mitogen-inducible gene 6 (Mig-6) have confirmed its role as a tumor suppressor and progesterone resistance factor in endometrium.
|
26450625 |
2015 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In this study, we show that MIG-6 also acts as a tumor suppressor in endometrial cancers associated with PTEN deficiency.
|
25377472 |
2014 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Ablation of Mig-6 has been shown to induce tumor formation in various tissues, supporting the tumor suppressor function of Mig-6.
|
24573418 |
2014 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In addition, knockdown of Mig-6 expression in H1299 and BE1 cells promoted EGF-induced tumor cell proliferation and migration.
|
21739478 |
2012 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We hypothesize that Mig-6 behaves as a tumor suppressor in PTC.
|
21190978 |
2011 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Mig-6 is a novel tumor suppressor that may be a candidate for targeted cancer therapeutics in patients with PTC refractory to conventional therapy.
|
19040996 |
2008 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These data suggests that MIG-6 is a tumor-suppressor gene and is therefore a candidate gene for the frequent 1p36 genetic alterations found in lung cancer.
|
16819504 |
2007 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
However, the precise role of Mig-6 has virtually been a mystery until recently, when we and others discovered that Mig-6 may play important roles in regulating stress response, maintaining homeostasis in tissues like joints or cardiac muscle, and functioning as a tumor suppressor.
|
17351343 |
2007 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In conclusion, RPL36A plays a role in tumor cell proliferation and may be a potential target for anticancer therapy of HCC.
|
14752831 |
2004 |