|
Adenocarcinoma Of Esophagus
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
RRAD hypermethylation showed highly discriminative receiver-operator characteristic curve profiles, clearly distinguishing esophageal squamous cell carcinoma (ESCC) from esophageal adenocarcinoma (EAC) or normal esophagus (NE) (p<0.01 and p<0.01, respectively).
|
24222170 |
2013 |
|
Adenocarcinoma of lung (disorder)
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
RRAD hypermethylation correlated with smoking history and poorer prognosis in lung adenocarcinomas.
|
17195088 |
2007 |
|
Adult Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
RRAD promotes EGFR-mediated STAT3 activation and induces temozolomide resistance of malignant glioblastoma.
|
25313011 |
2014 |
|
Amyotrophic Lateral Sclerosis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
We analyzed Rad expression in skeletal muscle from ALS patients and animal models and investigated whether it is regulated by oxidative stress.
|
20079427 |
2010 |
|
Amyotrophic Lateral Sclerosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
In human amyotrophic lateral sclerosis spinal cord, we find that RAD-23 abundance is increased and RAD-23 is mislocalized within motor neurons.
|
26490867 |
2015 |
|
Breast Carcinoma
|
0.330 |
Biomarker
|
disease |
BEFREE |
In transfection assays, PA-PEG1k-RGD showed significantly higher transfection efficiency in comparison with PAM-ABP or PA-PEG1k-RAD in αvβ3/5 positive MCF7 breast cancer and PANC-1 pancreatic cancer cells.
|
24894645 |
2014 |
|
Breast Carcinoma
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
None of the three RAD genes demonstrated somatic mutations in breast cancer cell lines.
|
10463575 |
1999 |
|
Breast Carcinoma
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
Loss of RRAD expression was found in 14 of 20 (70%) NSCLC cell lines, 11 of 11 (100%) SCLC cell lines, and 8 of 10 (80%) breast cancer cell lines; expression was not affected in normal bronchial and mammary epithelial cells.
|
17195088 |
2007 |
|
Breast Carcinoma
|
0.330 |
Biomarker
|
disease |
CTD_human |
Loss of RRAD expression was found in 14 of 20 (70%) NSCLC cell lines, 11 of 11 (100%) SCLC cell lines, and 8 of 10 (80%) breast cancer cell lines; expression was not affected in normal bronchial and mammary epithelial cells.
|
17195088 |
2007 |
|
Brugada Syndrome (disorder)
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Cardiomyocytes derived from induced pluripotent stem cells expressing RRAD variant recapitulated single-cell electrophysiological features of BrS, including altered Na+ current, as well as cytoskeleton disturbances.
|
31114854 |
2019 |
|
Carcinogenesis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
These results demonstrate a critical role for RRAD in GBM tumorigenesis and provide a rationale for the development of pharmacologic inhibitors of RRAD in GBM.
|
25313011 |
2014 |
|
Carcinogenesis
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
In vivo tumorigenesis analyses revealed that tumors derived from Rad knockdown cells were significantly smaller than those from control cells (P = 0.0131) and the preestablished tumors are reduced in size after the injection of siRad (P = 0.0064).
|
20460530 |
2010 |
|
Carcinogenesis
|
0.030 |
PosttranslationalModification
|
phenotype |
BEFREE |
However, the role of the methylation-induced RRAD inactivation in tumorigenesis remains unclear.
|
24648519 |
2014 |
|
Carcinoma
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Three out of the 5 somatic mutations were in RAD genes and a wider distribution of other HR genes was involved in non-serous carcinomas.
|
28541631 |
2017 |
|
Carcinoma of lung
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
In current study, using double directional genetic manipulation in well-established lung cancer cell lines, we showed that both E6 and E7 down-regulated the expression of RRAD at both protein and mRNA levels.
|
31839825 |
2019 |
|
Carcinoma of lung
|
0.030 |
Biomarker
|
disease |
BEFREE |
The use of RAD-ADAPT is demonstrated using an example that examines the impact of pharmacologic ATM and ATR kinase inhibition on human lung cancer cell line A549 after ionizing radiation.
|
28254357 |
2017 |
|
Carcinoma of lung
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
RRAD expression is frequently decreased in lung cancer.
|
25114038 |
2014 |
|
Cardiac Hypertrophy
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Rad GTPase deficiency leads to cardiac hypertrophy.
|
18056528 |
2007 |
|
Cardiomegaly
|
0.310 |
Biomarker
|
phenotype |
LHGDN |
Rad GTPase deficiency leads to cardiac hypertrophy.
|
18056528 |
2007 |
|
Cardiomegaly
|
0.310 |
Biomarker
|
phenotype |
CTD_human |
Rad GTPase deficiency leads to cardiac hypertrophy.
|
18056528 |
2007 |
|
Carotid artery occlusion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Baseline demographics differed in the following: the RAD group more frequently had a history of contralateral carotid artery stenting (1.4% vs. 0.3%, P = 0.009), anatomic high risk features (12.8% vs. 1.3%, P < 0.001), and contralateral carotid occlusion (5.3% vs. 2.4%, P = 0.005).
|
30223012 |
2019 |
|
Cerebrovascular accident
|
0.010 |
Biomarker
|
group |
BEFREE |
However, perioperative neurologic events (transient ischemic attack or stroke) was higher in symptomatic RAD versus symptomatic NORAD (6.7% vs. 2.6%, P = 0.020).
|
30223012 |
2019 |
|
Chagas Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
2b-RAD genotyping for population genomic studies of Chagas disease vectors: Rhodnius ecuadoriensis in Ecuador.
|
28723901 |
2017 |
|
Childhood Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
RRAD promotes EGFR-mediated STAT3 activation and induces temozolomide resistance of malignant glioblastoma.
|
25313011 |
2014 |
|
Chondrosarcoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
RGD peptide, alphavbeta3 monoclonal antibody and MAPK kinase (MEK) inhibitors (PD98059 and U0126) but not RAD peptide inhibited the OPN-induced increase of the migration and MMP-9 up-regulation of chondrosarcoma cells.
|
19475568 |
2009 |