Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Thus, these data support that RASA1 is inactivated by mutation or by suppressed expression in melanoma and that RASA1 plays a tumor suppressive role by inhibiting R-Ras, a previously less appreciated member of the Ras small GTPases.
|
26993606 |
2016 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
ARHI is a Ras-related imprinted tumor-suppressor gene that inhibits cancer cell growth and motility.
|
23604529 |
2013 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tissue microarray analysis (361 patients) indicated cofilin-1 staining positively correlating with tumor grade and p23 staining with ER positive status; both therefore merit further investigation as potential biomarkers.
|
24106833 |
2013 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This makes p23 an attractive target for combating tumor cell metastasis in breast cancer patients.
|
22074947 |
2012 |
Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
Promoter hypermethylation of Ras-related GTPase gene RRAD inactivates a tumor suppressor function in nasopharyngeal carcinoma.
|
22487779 |
2012 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The Ras-related, estrogen-regulated growth inhibitor (Rerg) is a Ras-related small GTPase and candidate tumor suppressor.
|
18374156 |
2008 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Accelerated tumor growth was observed in athymic mice after subcutaneous injection of R-Ras87L-expressing C33A cells.
|
16862428 |
2007 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In this study, we investigated how p23 regulates ER target gene activation and affects tumor growth and progression.
|
16809759 |
2006 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
By CGH, gains of chromosomal areas 1q23 approximately q24 (three tumors), 7p21 approximately p22 (three tumors), 7q (four tumors), and 19p13 (three tumors), as well as loss of chromosomal segment 9p22 approximately p23 (three tumors), were the most frequently observed imbalances.
|
15949565 |
2005 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We have recently shown that an MCF-7 tumor can be imaged in a mouse by PET with 64Cu-labeled Peptide nucleic acids (PNAs) tethered to the permeation peptide Lys4 that recognize the uniquely overexpressed and very abundant upstream of N-ras or N-ras related gene (unr mRNA) expressed in these cells.
|
16314303 |
2005 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These results highlight a previously uncharacterized subfamily of Ras-related genes that may have a tumor suppressor role in prostate cancer.
|
15033445 |
2004 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These data suggest that the oncogene R-Ras promotes tumor growth of cervical epithelial cells and increases their migration potential over collagen through a pathway that involves PI 3-K.
|
12548599 |
2003 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The gene LZTS1 has been mapped to the 8p22 through p23 region and identified as a potential tumor suppressor based on loss of heterozygosity studies using primary esophageal tumors.
|
12377406 |
2002 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In one of eight tumors from patients heterozygous for H-ras related BamHI restriction fragments, one allele was lost in the tumor but not in the noncancerous portion of the same kidney.
|
2457438 |
1988 |