|
Malignant neoplasm of breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
Multivariate analysis demonstrated RXRG protein as an independent predictor of longer breast cancer-specific survival and distant metastasis-free survival.
|
31558802 |
2019 |
|
Invasive carcinoma of breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
Retinoid X receptor gamma (RXRG) is an independent prognostic biomarker in ER-positive invasive breast cancer.
|
31558802 |
2019 |
|
Metabolic Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
This suggests that miR‑330‑5p and RXRγ may be target molecules for controlling metabolic diseases.
|
30015907 |
2018 |
|
Microcephaly
|
0.010 |
Biomarker
|
disease |
BEFREE |
Genotype-phenotype comparison with previously published patients allowed us to propose LMX1A and RXRG as potential candidate genes for intellectual disability, PBX1 as a probable candidate gene for renal malformation, and enabled us to narrow down a chromosome region associated with microcephaly.
|
27255444 |
2016 |
|
Prolactinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Whole-exome identifies RXRG and TH germline variants in familial isolated prolactinoma.
|
27245436 |
2016 |
|
Gestational Diabetes
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Together, these findings indicate that GC rs16847024, RXRG rs17429130 and RXRA rs4917356 were candidate susceptibility markers for GDM in Chinese females.
|
27636996 |
2016 |
|
Intellectual Disability
|
0.010 |
Biomarker
|
group |
BEFREE |
Genotype-phenotype comparison with previously published patients allowed us to propose LMX1A and RXRG as potential candidate genes for intellectual disability, PBX1 as a probable candidate gene for renal malformation, and enabled us to narrow down a chromosome region associated with microcephaly.
|
27255444 |
2016 |
|
Malignant tumor of colon
|
0.010 |
Biomarker
|
disease |
BEFREE |
Collectively, our results strongly support the use of SPIR or other RXRγ agonists with minimal side effects for colon cancer prevention and therapy.
|
24190430 |
2013 |
|
Colon Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Collectively, our results strongly support the use of SPIR or other RXRγ agonists with minimal side effects for colon cancer prevention and therapy.
|
24190430 |
2013 |
|
Anaplasia
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggest that RXRγ may play a role in the dedifferentiation and metastasis of PTC.
|
21355951 |
2011 |
|
Diabetic Retinopathy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Association between retinoid-X receptor-gamma genetic polymorphisms and diabetic retinopathy.
|
22180072 |
2011 |
|
Papillary thyroid carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggest that RXRγ may play a role in the dedifferentiation and metastasis of PTC.
|
21355951 |
2011 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The RXRγ mRNA expression, as well as extrathyroid invasion, LOP/C and advanced tumor stage, was further confirmed to be one of the independent predictive factors (Odds ratio: 6.545; 95% confidence interval: 1.575-27.208) of LNM using multivariate analysis.
|
21355951 |
2011 |
|
Tumor Cell Invasion
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
The RXRγ mRNA up-regulation was found to be positively correlated with extrathyroid invasion (r = 0.293, P = 0.019), advanced tumor stage (r = 0.318, P = 0.016) and lymph node metastasis (LNM) (r = 0.338, P = 0.005), as well as LOP/C (r = 0.345, P = 0.004), which was proposed as a histological characteristic of poor cellular differentiation.
|
21355951 |
2011 |
|
NEUROTICISM
|
0.010 |
Biomarker
|
disease |
BEFREE |
Although genome-wide significance was not reached for ZKPQ scales, lowest P values pinpointed to genes, RXRG for Sensation Seeking, GRM7 and ITK for Neuroticism Anxiety, and SPTLC3 gene for Aggression Hostility.
|
21368711 |
2011 |
|
Non-Small Cell Lung Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This finding suggests that methylation-associated downregulation of the RXRG gene may play a differential role in the carcinogenesis of NSCLCs according to smoking status, but further studies are needed to confirm this.
|
20113835 |
2010 |
|
Malignant Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
A significant correlation was observed between the expression of retinoid X receptor gamma and tumor stage, distant metastasis or the 5-year cancer specific survival rate.
|
17707062 |
2007 |
|
Renal Cell Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Cox regression analysis revealed that retinoid X receptor gamma expression, tumor status and lymph node status were significant independent prognostic factors in patients with renal cell carcinoma (p <0.05).
|
17707062 |
2007 |
|
Hyperlipidemia, Familial Combined
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
High frequency of a retinoid X receptor gamma gene variant in familial combined hyperlipidemia that associates with atherogenic dyslipidemia.
|
17272748 |
2007 |
|
Hyperlipidemia, Familial Combined
|
0.010 |
Biomarker
|
disease |
LHGDN |
High frequency of a retinoid X receptor gamma gene variant in familial combined hyperlipidemia that associates with atherogenic dyslipidemia.
|
17272748 |
2007 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Cox regression analysis revealed that retinoid X receptor gamma expression, tumor status and lymph node status were significant independent prognostic factors in patients with renal cell carcinoma (p <0.05).
|
17707062 |
2007 |
|
Primary malignant neoplasm
|
0.010 |
AlteredExpression
|
group |
BEFREE |
A significant correlation was observed between the expression of retinoid X receptor gamma and tumor stage, distant metastasis or the 5-year cancer specific survival rate.
|
17707062 |
2007 |
|
Atherogenic dyslipidaemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
High frequency of a retinoid X receptor gamma gene variant in familial combined hyperlipidemia that associates with atherogenic dyslipidemia.
|
17272748 |
2007 |
|
Thyroid Neoplasm
|
0.010 |
AlteredExpression
|
disease |
LHGDN |
Retinoid X receptor-gamma and peroxisome proliferator-activated receptor-gamma expression predicts thyroid carcinoma cell response to retinoid and thiazolidinedione treatment.
|
15299084 |
2004 |
|
Generalized Thyroid Hormone Resistance
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study is to search for mutation within the RXR-gamma gene in unrelated subjects with diagnosed RTH without mutations in the TRbeta gene.
|
15186611 |
2004 |