|
Autistic Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
No significant interaction between the rs6265 genotype and autism was observed for the BDNF expression.
|
29935919 |
2019 |
|
Autistic Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Pioglitazone abolishes cognition impairments as well as BDNF and neurotensin disturbances in a rat model of autism.
|
31036753 |
2019 |
|
Autistic Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Although no concrete biomarker has been identified for bone disorders in adulthood, reduced brain-derived neurotrophic factor (BDNF) concentrations in cord blood and BDNF DNA methylation might predict schizophrenia and possibly depression, bipolar disorder and autism.
|
31577039 |
2019 |
|
Autistic Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Therefore, we evaluate the ability of miR-153 to influence brain-derived neurotrophic factor (BDNF) of autism as well as proliferation and apoptosis of hippocampal neuron through the janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathway by targeting leptin receptor (LEPR).
|
30975733 |
2019 |
|
Autistic Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
However, these lobules have relatively high expression of <i>p75NTR</i>, which encodes a neurotrophin receptor implicated in autism.
|
31275178 |
2019 |
|
Autistic Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Brain Derived Neurotrophic Factor (BDNF), a key multifunctional regulator of brain development, has been related to autism in several ways.
|
31787877 |
2019 |
|
Autistic Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
ANKRD11 associated with intellectual disability and autism regulates dendrite differentiation via the BDNF/TrkB signaling pathway.
|
29274743 |
2018 |
|
Autistic Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Increased BDNF production and changes in the metabolism of tryptophan are associated with many ASD characteristics, showing particularly strong associations with childhood autism and Intellectual and Developmental Disabilities.
|
30033880 |
2018 |
|
Autistic Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The present meta-analysis study led to conclusion that BDNF might play role in autism initiation/ propagation and therefore it can be considered as a possible biomarker of ASD.
|
28138831 |
2017 |
|
Autistic Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Higher peripheral BDNF in autism is concordant with several neurological and psychological theories on the causes and symptoms of this condition, and it contrasts notably with the lower levels of BDNF found in schizophrenia, bipolar disorder, and depression.
|
27501933 |
2017 |
|
Autistic Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Brain-derived neurotrophic factor (BDNF) that is involved in the pathogenesis of obesity, type 2 diabetes mellitus, and metabolic syndrome is also altered in depression, schizophrenia, bipolar disorder, and autism.
|
26706021 |
2016 |
|
Autistic Disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Within the WAGR group, BDNF+/- subjects (n = 15), compared with BDNF intact (+/+) subjects (n = 13), had lower adaptive behaviour (p = .02), reduced cognitive functioning (p = .04), higher levels of reported historical (p = .02) and current (p = .02) social impairment, and higher percentage meeting cut-off score for autism (p = .047) on Autism Diagnostic Interview-Revised.
|
23517654 |
2014 |
|
Autistic Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Based on these evidences, it is proposed that selective delivery of BDNF and methods designed to augment the production of anti-inflammatory cytokines and eicosanoids and PUFAs may prevent, arrest, or reverse the autism disease process.
|
23911220 |
2013 |
|
Autistic Disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These data demonstrate that increased levels of BDNF-immunoreactive protein in autism are not transcriptionally driven.
|
22437340 |
2012 |
|
Autistic Disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
By substantiating the previously observed increase in BDNF levels in autistic children in a larger patient set, and suggesting a genetic association between NTRK2 and autism, this study integrates evidence from multiple levels supporting the hypothesis that alterations in BDNF/tyrosine kinase B (TrkB) signaling contribute to an increased vulnerability to autism.
|
20662941 |
2010 |
|
Autistic Disorder
|
0.400 |
Biomarker
|
disease |
CTD_human |
By substantiating the previously observed increase in BDNF levels in autistic children in a larger patient set, and suggesting a genetic association between NTRK2 and autism, this study integrates evidence from multiple levels supporting the hypothesis that alterations in BDNF/tyrosine kinase B (TrkB) signaling contribute to an increased vulnerability to autism.
|
20662941 |
2010 |
|
Autistic Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results suggest a potential association between BDNF and autism in the Chinese population.
|
20201430 |
2009 |
|
Autistic Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Developmentally regulated Ca2+-dependent activator protein for secretion 2 (CAPS2) is involved in BDNF secretion and is associated with autism susceptibility.
|
19238500 |
2009 |
|
Autistic Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
We suggest that BDNF has a possible role in the pathogenesis of autism.
|
19582215 |
2009 |
|
Autistic Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Deletion of BDNF and SLC1A2 occurred in patients with autism more frequently than in those without autism.
|
19096215 |
2008 |
|
Autistic Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The JARID1C-regulated genes SCN2A, CACNA1H, BDNF, and SLC18A1 have previously been associated with autism and cognitive dysfunction.
|
18203167 |
2008 |
|
Autistic Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our results suggest that a disturbance in CADPS2-mediated neurotrophin release contributes to autism susceptibility.
|
17380209 |
2007 |
|
Autistic Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
We suggest that BDNF has a possible role in the pathogenesis of autism through its neurotrophic effects on the serotonergic system.
|
17349978 |
2007 |
|
Autistic Disorder
|
0.400 |
Biomarker
|
disease |
CTD_human |
We suggest that BDNF has a possible role in the pathogenesis of autism through its neurotrophic effects on the serotonergic system.
|
17349978 |
2007 |
|
Autistic Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Attempts to prove the BDNF hyperactivity hypothesis may lead investigators in a new direction for the study of the pathogenesis of autism and the development of an effective intervention of this disorder.
|
15893122 |
2005 |