BDNF, brain derived neurotrophic factor, 627

N. diseases: 992; N. variants: 56
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0014544
Disease: Epilepsy
Epilepsy
0.400 Biomarker disease BEFREE Thereafter, we discuss aspiring strategies for targeting BDNF/TrkB signaling so as to prevent epilepsy following an insult or suppress its expression once developed. 31377199 2020
CUI: C0014544
Disease: Epilepsy
Epilepsy
0.400 AlteredExpression disease BEFREE Our results suggest that the protection against neuronal loss in specific limbic regions and overexpressed BDNF in the mossy fibers resulting from the repeated treatment with Ago and LCM, respectively, during SE is not a prerequisite for alleviation of epileptogenesis and development of epilepsy. 30738136 2019
CUI: C0014544
Disease: Epilepsy
Epilepsy
0.400 AlteredExpression disease BEFREE Compared with miR-103a inhibitors alone, epilepsy rats treated with BDNF-siRNA combined with miR-103a inhibitors significantly increased expression of GFAP in hippocampal tissues of epilepsy rats, increased number of apoptotic neurons and significantly decreased the number of surviving neurons. 31049031 2019
CUI: C0014544
Disease: Epilepsy
Epilepsy
0.400 Biomarker disease BEFREE The current review is an attempt to collate the available preclinical and clinical studies to establish the therapeutic potential of various dietary flavonoids in comprehensive management of epilepsy with relation to CREB-BDNF pathway. 31400269 2019
CUI: C0014544
Disease: Epilepsy
Epilepsy
0.400 AlteredExpression disease BEFREE Silencing lncRNA PVT1 inhibits activation of astrocytes and increases BDNF expression in hippocampus tissues of rats with epilepsy by downregulating the Wnt signaling pathway. 30805931 2019
CUI: C0014544
Disease: Epilepsy
Epilepsy
0.400 AlteredExpression disease BEFREE Downregulated hippocampal expression of brain derived neurotrophic factor and tyrosine kinase B in a rat model of comorbid epilepsy and depression. 30741614 2019
CUI: C0014544
Disease: Epilepsy
Epilepsy
0.400 Biomarker disease BEFREE We previously found that neurons respond to prolonged BDNF exposure (both in vivo (in models of epilepsy and TBI) and in vitro (in BDNF treated primary neuronal cultures)) by activating the Janus Kinase/Signal Transducer and Activator of Transcription (JAK/STAT) signaling pathway. 31455240 2019
CUI: C0014544
Disease: Epilepsy
Epilepsy
0.400 Biomarker disease BEFREE This retrospective cross-sectional study provides preliminary evidence for a genetic basis of psychiatric comorbidities in epilepsy and suggests that BDNF and COMT may play an important role in the pathophysiology of mental health problems in this vulnerable population. 30909076 2019
CUI: C0014544
Disease: Epilepsy
Epilepsy
0.400 Biomarker disease BEFREE In this review article, we discuss recent finding illuminating how mBDNF-TrkB and proBDNF-p75<sup>NTR</sup> signaling pathways regulate GABA related neurotransmission under physiological conditions and during epilepsy. 30210299 2018
CUI: C0014544
Disease: Epilepsy
Epilepsy
0.400 Biomarker disease BEFREE <b>Background:</b> Brain-derived neurotrophic factor (BDNF) and insulin-like growth factor 1 (IGF-1) may regulate the autonomic nervous system (ANS) in epilepsy. 30524358 2018
CUI: C0014544
Disease: Epilepsy
Epilepsy
0.400 Biomarker disease BEFREE We also assayed the cyclic adenosine monophosphate response element-binding (CREB) and glucocorticoid receptor (GR) genes as there is experimental evidence of changes in their expression associated with BDNF and epilepsy. 28527108 2018
CUI: C0014544
Disease: Epilepsy
Epilepsy
0.400 Biomarker disease BEFREE Although the full agonist effects of brain-derived neurotrophic factor and tropomyosin receptor kinase B activation in epilepsy models have been controversial, the present results indicate that such trophic activation by a partial agonist may potentially serve as an effective therapeutic option for prophylactic treatment of posttraumatic epileptogenesis, and treatment of other neurological and psychiatric disorders whose pathogenesis involves impaired parvalbumin interneuronal function. 29408225 2018
CUI: C0014544
Disease: Epilepsy
Epilepsy
0.400 AlteredExpression disease BEFREE In addition, an obvious decrease in the PSD95 and BDNF expression levels of epileptic A1R KO mice was observed 7 days after complete kindling. 28492982 2018
CUI: C0014544
Disease: Epilepsy
Epilepsy
0.400 Biomarker disease BEFREE We targeted those publications addressing both in vitro and in vivo evidences of relationship between BDNF and epilepsy. 30262417 2018
CUI: C0014544
Disease: Epilepsy
Epilepsy
0.400 AlteredExpression disease BEFREE Rats with epilepsy presented decreased BDNF levels compared with control rats. 29098710 2018
CUI: C0014544
Disease: Epilepsy
Epilepsy
0.400 Biomarker disease BEFREE Thus, ECB device-mediated long-term supplementation of BDNF in the epileptic tissue may represent a valid therapeutic strategy against epilepsy and some of its co-morbidities. 29766029 2018
CUI: C0014544
Disease: Epilepsy
Epilepsy
0.400 AlteredExpression disease BEFREE We aimed to determine whether a common polymorphism of the brain-derived neurotrophic factor (BDNF), which constitutes an important and ubiquitously expressed neurotrophine in the brain, affects the stimulation threshold of ECTs required to induce an epileptic seizure over time. 27787610 2017
CUI: C0014544
Disease: Epilepsy
Epilepsy
0.400 AlteredExpression disease BEFREE The present results demonstrated that inhibition of Kir4.1 channels facilitates BDNF expression in astrocytes primarily by activating the Ras/Raf/MEK/ERK pathway, which may be linked to the development of epilepsy and other neuropsychiatric disorders. 29358904 2017
CUI: C0014544
Disease: Epilepsy
Epilepsy
0.400 AlteredExpression disease BEFREE BDNF levels and ERK and mTOR activation were decreased in rats with epilepsy and resistance exercise restored these to control levels. 28078614 2017
CUI: C0014544
Disease: Epilepsy
Epilepsy
0.400 AlteredExpression disease BEFREE The expression of brain-derived neurotrophic factor (BDNF) in the CA3 area of the hippocampus in the comorbidity group was significantly higher than that in the epilepsy group according to the immunohistochemical test (P<0.05). 28559979 2017
CUI: C0014544
Disease: Epilepsy
Epilepsy
0.400 Biomarker disease BEFREE We investigated the influence of variants in the genes encoding neuron-restrictive silencer factor (NRSF) and brain-derived neurotrophic factor (BDNF), proteins previously associated with cognition and epilepsy, on cognitive function in people with newly diagnosed epilepsy. 26708060 2016
CUI: C0014544
Disease: Epilepsy
Epilepsy
0.400 Biomarker disease BEFREE A putative role of the brain-derived neurotrophic factor (BDNF) in epilepsy has emerged from in vitro and animal models, but few studies have analyzed human samples. 26621122 2016
CUI: C0014544
Disease: Epilepsy
Epilepsy
0.400 GeneticVariation disease BEFREE However, whether BDNF Val66Met polymorphism is associated with epilepsy remains controversial. 26000807 2016
CUI: C0014544
Disease: Epilepsy
Epilepsy
0.400 GeneticVariation disease BEFREE In conclusion, our results suggest that BDNF polymorphisms might contribute to the risk of epilepsy in Malaysian Indians and Chinese. 25876511 2016
CUI: C0014544
Disease: Epilepsy
Epilepsy
0.400 GeneticVariation disease BEFREE We identified a novel intragenic deletion of maternal origin in two siblings with mild ID and epilepsy in the CADPS2 gene, encoding for a synaptic protein involved in neurotrophin release and interaction with dopamine receptor type 2 (D2DR). 24737869 2014