BDNF, brain derived neurotrophic factor, 627

N. diseases: 992; N. variants: 56
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.400 Biomarker group BEFREE Brain-derived neurotrophic factor (BDNF) is suggested to be a likely candidate biomarker for the diagnosis and treatment evaluation in psychosis. 31688384 2020
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.400 Biomarker group BEFREE In this study, we examined whether brain-derived neurotrophic factor (BDNF) and its receptor TrkB signaling plays a role in the risk for psychosis after exposure of cannabinoid (CB) receptor agonist during adolescence. 30629965 2019
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.400 GeneticVariation group BEFREE Chronic methamphetamine interacts with BDNF Val66Met to remodel psychosis pathways in the mesocorticolimbic proteome. 31822818 2019
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.400 Biomarker group BEFREE Multiple regression analysis revealed a significant positive association of plasma BDNF levels with planning ability across all groups.<b>Conclusions:</b> The lower peripheral BDNF levels in ARMS compared to FEP and CS might point towards an important drop of this neurotrophin prior to the onset of frank psychosis. 29938562 2019
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.400 GeneticVariation group BEFREE Trend level gene-gender interaction effect for the BDNF rs6265 variant on age of onset of psychosis. 31445421 2019
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.400 GeneticVariation group BEFREE The BDNF-Val66Met polymorphism may index susceptibility to expression of psychosis along a spectrum. 29785763 2019
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.400 AlteredExpression group BEFREE However, baseline levels of serum BDNF did not predict the development of psychosis (OR=0.64, CI = 0.40 - 1.02) or remission (OR=0.83, CI = 0.60 - 1.15) from UHR status. 29584866 2018
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.400 AlteredExpression group BEFREE High serum levels of BDNF and glutamate were associated with response to clozapine, while glutamate levels correlated with the psychosis severity in clozapine responders only. 28599751 2018
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.400 GeneticVariation group BEFREE We aimed to investigate whether there is a gene-environment interaction in the relationship between stress and BDNF Val66Met polymorphism in relation to dietary patterns in a sample of subjects with early psychosis. 27629407 2018
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.400 GeneticVariation group BEFREE These findings provide evidence of the important role of early cannabis use and the Val66Met BDNF polymorphism on age at psychosis onset and they point out to sex-specific differences in cannabis use patterns. 28142064 2017
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.400 AlteredExpression group BEFREE Clinical, illness course and treatment factors might influence the variation of BDNF serum levels in patients with psychosis. 28550022 2017
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.400 Biomarker group BEFREE This study aimed to investigate the role of BDNF in MDMA-induced dependence and psychosis. 28472632 2017
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.400 GeneticVariation group BEFREE One of the most studied genetic phenotypes for psychosis is brain-derived neurotrophic factor (BDNF) Val66Met polymorphisms. 26603624 2016
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.400 GeneticVariation group BEFREE To begin to address this issue, we conducted high-coverage targeted exome capture in a subset of neurotrophin genes in 48 comprehensively characterized cases with schizophrenia-related psychosis. 26215504 2015
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.400 Biomarker group BEFREE Disrupting of BDNF and its downstream signals has been found in many neuropsychological diseases, including attention-deficit hyperactivity disorder (ADHD), a common mental disorder which is prevalent in childhood. 25354496 2015
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.400 GeneticVariation group BEFREE Further, our study supports a two hit model including a history of childhood trauma as well as genetic vulnerability (met carriers of the BDNF val66met) behind reduced volume of hippocampal subfields in psychosis. 25246365 2014
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.400 GeneticVariation group BEFREE The three-way pICA approach identified links between a SNP component (pointing to brain function and mental disorder associated genes, including BDNF, GRIN2B and NRG1), a functional component related to increased activation in the precuneus area, and a gray matter component comprising part of the default mode network and the caudate. 24795156 2014
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.400 GeneticVariation group BEFREE Brain derived neurotrophic factor (BDNF) is important for brain development and plasticity, and here we tested if the functional BDNF val66met variant modulates the association between high levels of childhood abuse, cognitive function, and brain abnormalities in psychoses. 23876786 2013
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.400 GeneticVariation group BEFREE The present study aimed to explore possible effects of BDNF Val66Met polymorphism variations on progressive structural brain changes after 3 years from the first episode of psychosis. 23748016 2013
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.400 GeneticVariation group BEFREE A complex interplay between BDNF serum concentrations, personality traits, BDNF Val66Met polymorphism, and psychotic symptomatology has been arisen but further investigation is needed to better clarify the observed associations. 23333821 2013
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.400 Biomarker group BEFREE The current, limited evidence points to genes that are not specifically involved in psychosis but more generally in regulating mood (serotonin transporter gene), neuroplasticity (brain-derived neurotrophic factor), and the stress-response system (FKBP5), in line with a general effect of CT on a range of mental disorders, rather than suggesting specificity for psychosis. 23327756 2013
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.400 GeneticVariation group BEFREE There was no difference in the proportion of Met allele carriers between FEP patients and controls, and no significant influence of BDNF genotype on cognitive test scores in either of the psychosis groups. 23429848 2012
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.400 Biomarker group BEFREE Hippocampal volume and BDNF genotyping were obtained for 58 patients with first-episode psychosis and 39 healthy volunteers. 22192502 2012
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.400 GeneticVariation group BEFREE This study aimed to investigate the degree of DNA methylation at the promoter region of the brain-derived neurotrophic factor (BDNF) gene, as one of the candidate genes associated with major psychoses, in peripheral blood mononuclear cells isolated from 94 patients with BD (BD I=49, BD II=45) and 52 healthy controls. 22353757 2012
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.400 GeneticVariation group BEFREE The Met allele of the functional polymorphism, BDNF Val66Met, is associated with psychotic disorders. 21728904 2012