BDNF, brain derived neurotrophic factor, 627

N. diseases: 992; N. variants: 56
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 GeneticVariation disease BEFREE As studies testing the BDNF system across molecular levels are sparse, this study aimed at investigating the BDNF val66met genotype, BDNF DNA methylation changes and peripheral BDNF serum levels in acute and remitted phases of MDD (major depressive disorder) and BD (bipolar disorder) and healthy controls. 30929061 2020
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Biomarker disease BEFREE This study suggests that in patients who have experienced AIS, there is no significant relationship between major depression and basal proinflammatory cytokines (TNF-α, IL-1 β, IL-18), BDNF, and NSE. 31142907 2020
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Biomarker disease BEFREE Our findings provide further evidence for an interaction of the HPA axis and the neurotrophin system in major depression. 31295515 2019
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 AlteredExpression disease BEFREE Ratio of plasma BDNF to leptin levels are associated with treatment response in major depressive disorder but not in panic disorder: A 12-week follow-up study. 31465895 2019
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 AlteredExpression disease BEFREE In our sample, baseline serum BDNF levels did not predict major depression and the clinical characteristics of the patients did not predict their BDNF levels. 31231276 2019
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 AlteredExpression disease BEFREE Acute and subsequent continuation electroconvulsive therapy elevates serum BDNF levels in patients with major depression. 31000384 2019
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 AlteredExpression disease BEFREE In this review, we will provide recent advances on glial dysfunctions, the role of inflammatory cytokines, transcription factors, and brain derived neurotrophic factor underlying the pathophysiology of major depressive disorder. 31601403 2019
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Biomarker disease BEFREE Brain-derived neurotrophic factor (BDNF), an essential factor for maintaining brain functions, has been reported to be reduced in various neurological diseases, including Alzheimer's disease and major depression. 30753865 2019
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 AlteredExpression disease BEFREE Accuracy of brain-derived neurotrophic factor levels for differentiating between Taiwanese patients with major depressive disorder or schizophrenia and healthy controls. 30794585 2019
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 AlteredExpression disease BEFREE : The results suggest that the existence of major depression in pregnant women may negatively affect fetal circulating BDNF levels. 30905131 2019
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Biomarker disease BEFREE Low serum brain-derived neurotrophic factor is associated with suicidal ideation in major depressive disorder. 30640051 2019
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Biomarker disease BEFREE Serum brain-derived neurotrophic factor (BDNF) at rest and after acute aerobic exercise in major depressive disorder. 30583245 2019
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 AlteredExpression disease BEFREE In conclusion, these results showed that BDNF exon IX promoter methylation levels, serum BDNF protein level, and serum BDNF mRNA level could contribute to the pathophysiology of a major depressive disorder. 31027379 2019
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 GeneticVariation disease BEFREE We investigated whether single nucleotide polymorphisms (SNPs) associated with neuroplasticity and activity of monoamine neurotransmitters, such as the brain-derived neurotrophic factor (BDNF, rs6265), the serotonin transporter (SLC6A4, rs25531), the tryptophan hydroxylase 1 (TPH1, rs1800532), the 5-hydroxytryptamine receptor 2A (HTR2A, rs6311, rs6313, rs7997012), and the catechol-O-methyltransferase (COMT, rs4680) genes, are associated with efficacy of transcranial direct current stimulation (tDCS) in major depression. 31721892 2019
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 GeneticVariation disease BEFREE BDNF genetic variants and methylation: effects on cognition in major depressive disorder. 31636250 2019
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 GeneticVariation disease BEFREE BDNF and NRG1 polymorphisms and temperament in selective serotonin reuptake inhibitor-treated patients with major depression. 29310728 2018
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Biomarker disease BEFREE Such an association would be consistent with low brain-derived neurotrophic factor mediating the effect of early life adversity on adulthood suicide and major depressive disorder. 29432620 2018
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 GeneticVariation disease BEFREE The effects of 5-HTTLPR and BDNF Val66Met polymorphisms on neurostructural changes in major depressive disorder. 29414128 2018
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Biomarker disease BEFREE Furthermore, it is thought that BDNF also plays a crucial role in major depression. 29450725 2018
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 GeneticVariation disease BEFREE Val66Met polymorphism association with serum BDNF and inflammatory biomarkers in major depression. 28656803 2018
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Biomarker disease BEFREE The effect of exercise on resting concentrations of peripheral brain-derived neurotrophic factor (BDNF) in major depressive disorder: A meta-analysis. 30219561 2018
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 AlteredExpression disease BEFREE This paper sought to investigate correlations between serum BDNF and plasma levels of MHPG and HVA in people with major depression (MD). 29541037 2018
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 AlteredExpression disease BEFREE A comprehensive review of genetic and epigenetic mechanisms that regulate BDNF expression and function with relevance to major depressive disorder. 29243873 2018
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 AlteredExpression disease BEFREE Effect of electroconvulsive therapy on brain-derived neurotrophic factor levels in patients with major depressive disorder. 30273985 2018
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Biomarker disease BEFREE Does Physical Exercise Increase Brain-Derived Neurotrophic Factor in Major Depressive Disorder? A Meta-Analysis. 29930221 2018