Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
As studies testing the BDNF system across molecular levels are sparse, this study aimed at investigating the BDNF val66met genotype, BDNF DNA methylation changes and peripheral BDNF serum levels in acute and remitted phases of MDD (major depressive disorder) and BD (bipolar disorder) and healthy controls.
|
30929061 |
2020 |
Unipolar Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
This study suggests that in patients who have experienced AIS, there is no significant relationship between major depression and basal proinflammatory cytokines (TNF-α, IL-1 β, IL-18), BDNF, and NSE.
|
31142907 |
2020 |
Unipolar Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our findings provide further evidence for an interaction of the HPA axis and the neurotrophin system in major depression.
|
31295515 |
2019 |
Unipolar Depression
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Ratio of plasma BDNF to leptin levels are associated with treatment response in major depressive disorder but not in panic disorder: A 12-week follow-up study.
|
31465895 |
2019 |
Unipolar Depression
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In our sample, baseline serum BDNF levels did not predict major depression and the clinical characteristics of the patients did not predict their BDNF levels.
|
31231276 |
2019 |
Unipolar Depression
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Acute and subsequent continuation electroconvulsive therapy elevates serum BDNF levels in patients with major depression.
|
31000384 |
2019 |
Unipolar Depression
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In this review, we will provide recent advances on glial dysfunctions, the role of inflammatory cytokines, transcription factors, and brain derived neurotrophic factor underlying the pathophysiology of major depressive disorder.
|
31601403 |
2019 |
Unipolar Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Brain-derived neurotrophic factor (BDNF), an essential factor for maintaining brain functions, has been reported to be reduced in various neurological diseases, including Alzheimer's disease and major depression.
|
30753865 |
2019 |
Unipolar Depression
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Accuracy of brain-derived neurotrophic factor levels for differentiating between Taiwanese patients with major depressive disorder or schizophrenia and healthy controls.
|
30794585 |
2019 |
Unipolar Depression
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
: The results suggest that the existence of major depression in pregnant women may negatively affect fetal circulating BDNF levels.
|
30905131 |
2019 |
Unipolar Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Low serum brain-derived neurotrophic factor is associated with suicidal ideation in major depressive disorder.
|
30640051 |
2019 |
Unipolar Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Serum brain-derived neurotrophic factor (BDNF) at rest and after acute aerobic exercise in major depressive disorder.
|
30583245 |
2019 |
Unipolar Depression
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, these results showed that BDNF exon IX promoter methylation levels, serum BDNF protein level, and serum BDNF mRNA level could contribute to the pathophysiology of a major depressive disorder.
|
31027379 |
2019 |
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We investigated whether single nucleotide polymorphisms (SNPs) associated with neuroplasticity and activity of monoamine neurotransmitters, such as the brain-derived neurotrophic factor (BDNF, rs6265), the serotonin transporter (SLC6A4, rs25531), the tryptophan hydroxylase 1 (TPH1, rs1800532), the 5-hydroxytryptamine receptor 2A (HTR2A, rs6311, rs6313, rs7997012), and the catechol-O-methyltransferase (COMT, rs4680) genes, are associated with efficacy of transcranial direct current stimulation (tDCS) in major depression.
|
31721892 |
2019 |
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
BDNF genetic variants and methylation: effects on cognition in major depressive disorder.
|
31636250 |
2019 |
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
BDNF and NRG1 polymorphisms and temperament in selective serotonin reuptake inhibitor-treated patients with major depression.
|
29310728 |
2018 |
Unipolar Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Such an association would be consistent with low brain-derived neurotrophic factor mediating the effect of early life adversity on adulthood suicide and major depressive disorder.
|
29432620 |
2018 |
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The effects of 5-HTTLPR and BDNF Val66Met polymorphisms on neurostructural changes in major depressive disorder.
|
29414128 |
2018 |
Unipolar Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Furthermore, it is thought that BDNF also plays a crucial role in major depression.
|
29450725 |
2018 |
Unipolar Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Val66Met polymorphism association with serum BDNF and inflammatory biomarkers in major depression.
|
28656803 |
2018 |
Unipolar Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
The effect of exercise on resting concentrations of peripheral brain-derived neurotrophic factor (BDNF) in major depressive disorder: A meta-analysis.
|
30219561 |
2018 |
Unipolar Depression
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
This paper sought to investigate correlations between serum BDNF and plasma levels of MHPG and HVA in people with major depression (MD).
|
29541037 |
2018 |
Unipolar Depression
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
A comprehensive review of genetic and epigenetic mechanisms that regulate BDNF expression and function with relevance to major depressive disorder.
|
29243873 |
2018 |
Unipolar Depression
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Effect of electroconvulsive therapy on brain-derived neurotrophic factor levels in patients with major depressive disorder.
|
30273985 |
2018 |
Unipolar Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Does Physical Exercise Increase Brain-Derived Neurotrophic Factor in Major Depressive Disorder? A Meta-Analysis.
|
29930221 |
2018 |